Cortical Excitability Measured with nTMS and MEG during Stroke Recovery

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Makela , J P , Lioumis , P , Laaksonen , K , Forss , N , Tatlisumak , T , Kaste , M & Mustanoja , S 2015 , ' Cortical Excitability Measured with nTMS and MEG during Stroke Recovery ' , Neural Plasticity . https://doi.org/10.1155/2015/309546

Title: Cortical Excitability Measured with nTMS and MEG during Stroke Recovery
Author: Makela, Jyrki P.; Lioumis, Pantelis; Laaksonen, Kristina; Forss, Nina; Tatlisumak, Turgut; Kaste, Markku; Mustanoja, Satu
Other contributor: University of Helsinki, BioMag Laboratory
University of Helsinki, Neuroscience Center
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Neurosciences






Date: 2015
Language: eng
Number of pages: 8
Belongs to series: Neural Plasticity
ISSN: 2090-5904
DOI: https://doi.org/10.1155/2015/309546
URI: http://hdl.handle.net/10138/176380
Abstract: Objective. Stroke alters cortical excitability both in the lesioned and in the nonlesioned hemisphere. Stroke recovery has been studied using transcranial magnetic stimulation (TMS). Spontaneous brain oscillations and somatosensory evoked fields (SEFs) measured by magnetoencephalography (MEG) are modified in stroke patients during recovery. Methods. We recorded SEFs and spontaneous MEG activity and motor threshold (MT) short intracortical inhibition (SICI) and intracortical facilitation (ICF) with navigated TMS (nTMS) at one and three months after first-ever hemispheric ischemic strokes. Changes of MEG and nTMS parameters attributed to gamma-aminobutyrate and glutamate transmission were compared. Results. ICF correlated with the strength and extent of SEF source areas depicted by MEG at three months. The nTMS MT and event-related desynchronization (ERD) of beta-band MEG activity and SICI and the beta-band MEG event-related synchronization (ERS) were correlated, but less strongly. Conclusions. This first report using sequential nTMS and MEG in stroke recovery found intra-and interhemispheric correlations of nTMS and MEG estimates of cortical excitability. ICF and SEF parameters, MT and the ERD of the lesioned hemisphere, and SICI and ERS of the nonlesioned hemisphere were correlated. Covarying excitability in the lesioned and nonlesioned hemispheres emphasizes the importance of the hemispheric balance of the excitability of the sensorimotor system.
Subject: TRANSCRANIAL MAGNETIC STIMULATION
PRIMARY MOTOR CORTEX
EVENT-RELATED DESYNCHRONIZATION
PROGRESSIVE MYOCLONUS EPILEPSY
HUMAN SENSORIMOTOR-CORTEX
CEREBRAL-ARTERY STROKE
SOMATOSENSORY CORTEX
BASIC PRINCIPLES
MOVEMENT
INHIBITION
3112 Neurosciences
3124 Neurology and psychiatry
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