Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D : a cross-sectional analysis in population-based data

Show full item record



Permalink

http://hdl.handle.net/10138/176532

Citation

Vogt , S , Wahl , S , Kettunen , J , Breitner , S , Kastenmueller , G , Gieger , C , Suhre , K , Waldenberger , M , Kratzsch , J , Perola , M , Salomaa , V , Blankenberg , S , Zeller , T , Soininen , P , Kangas , A J , Peters , A , Grallert , H , Ala-Korpela , M & Thorand , B 2016 , ' Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D : a cross-sectional analysis in population-based data ' International Journal of Epidemiology , vol. 45 , no. 5 , pp. 1469-1481 . DOI: 10.1093/ije/dyw222

Title: Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D : a cross-sectional analysis in population-based data
Author: Vogt, Susanne; Wahl, Simone; Kettunen, Johannes; Breitner, Susanne; Kastenmueller, Gabi; Gieger, Christian; Suhre, Karsten; Waldenberger, Melanie; Kratzsch, Juergen; Perola, Markus; Salomaa, Veikko; Blankenberg, Stefan; Zeller, Tanja; Soininen, Pasi; Kangas, Antti J.; Peters, Annette; Grallert, Harald; Ala-Korpela, Mika; Thorand, Barbara
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-10
Language: eng
Number of pages: 13
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
URI: http://hdl.handle.net/10138/176532
Abstract: Background: Numerous observational studies have observed associations between vitamin D deficiency and cardiometabolic diseases, but these findings might be confounded by obesity. A characterization of the metabolic profile associated with serum 25-hydroxyvitamin D [25(OH)D] levels, in general and stratified by abdominal obesity, may help to untangle the relationship between vitamin D, obesity and cardiometabolic health. Methods: Serum metabolomics measurements were obtained from a nuclear magnetic resonance spectroscopy (NMR)- and a mass spectrometry (MS)-based platform. The discovery was conducted in 1726 participants of the population-based KORA-F4 study, in which the associations of the concentrations of 415 metabolites with 25(OH)D levels were assessed in linear models. The results were replicated in 6759 participants (NMR) and 609 (MS) participants, respectively, of the population-based FINRISK 1997 study. Results: Mean [standard deviation (SD)] 25(OH)D levels were 15.2 (7.5) ng/ml in KORA F4 and 13.8 (5.9) ng/ml in FINRISK 1997; 37 metabolites were associated with 25(OH) D in KORA F4 at P <0.05/415. Of these, 30 associations were replicated in FINRISK 1997 at P <0.05/37. Among these were constituents of (very) large very-low-density lipoprotein and small low-density lipoprotein subclasses and related measures like serum triglycerides as well as fatty acids and measures reflecting the degree of fatty acid saturation. The observed associations were independent of waist circumference and generally similar in abdominally obese and non-obese participants. Conclusions: Independently of abdominal obesity, higher 25(OH)D levels were associated with a metabolite profile characterized by lower concentrations of atherogenic lipids and a higher degree of fatty acid polyunsaturation. These results indicate that the relationship between vitamin D deficiency and cardiometabolic diseases is unlikely to merely reflect obesity-related pathomechanisms.
Subject: 25(OH)D
vitamin D
metabolomics
obesity
molecular epidemiology
VITAMIN-D STATUS
MENDELIAN RANDOMIZATION
CARDIOVASCULAR RISK
LIPOPROTEIN-LIPASE
HEART-DISEASE
D DEFICIENCY
HEALTH
OBESITY
METAANALYSIS
COHORT
3142 Public health care science, environmental and occupational health
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
dyw222.pdf 573.6Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record