Metabolic profiling of alcohol consumption in 9778 young adults

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http://hdl.handle.net/10138/176534

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Wurtz , P , Cook , S , Wang , Q , Tiainen , M , Tynkkynen , T , Kangas , A J , Soininen , P , Laitinen , J , Viikari , J , Kahonen , M , Lehtimaki , T , Perola , M , Blankenberg , S , Zeller , T , Mannisto , S , Salomaa , V , Jarvelin , M-R , Raitakari , O T , Ala-Korpela , M & Leon , D A 2016 , ' Metabolic profiling of alcohol consumption in 9778 young adults ' , International Journal of Epidemiology , vol. 45 , no. 5 , pp. 1493-1506 . https://doi.org/10.1093/ije/dyw175

Titel: Metabolic profiling of alcohol consumption in 9778 young adults
Författare: Wurtz, Peter; Cook, Sarah; Wang, Qin; Tiainen, Mika; Tynkkynen, Tuulia; Kangas, Antti J.; Soininen, Pasi; Laitinen, Jaana; Viikari, Jorma; Kahonen, Mika; Lehtimaki, Terho; Perola, Markus; Blankenberg, Stefan; Zeller, Tanja; Mannisto, Satu; Salomaa, Veikko; Jarvelin, Marjo-Riitta; Raitakari, Olli T.; Ala-Korpela, Mika; Leon, David A.
Upphovmannens organisation: Institute for Molecular Medicine Finland
Quantitative Genetics
Datum: 2016-10
Språk: eng
Sidantal: 14
Tillhör serie: International Journal of Epidemiology
ISSN: 0300-5771
DOI: https://doi.org/10.1093/ije/dyw175
Permanenta länken (URI): http://hdl.handle.net/10138/176534
Abstrakt: Background: High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favourable and adverse effects on cardiometabolic risk markers. We aimed to characterize the associations of usual alcohol consumption with a comprehensive systemic metabolite profile in young adults. Methods: Cross-sectional associations of alcohol intake with 86 metabolic measures were assessed for 9778 individuals from three population-based cohorts from Finland (age 24-45 years, 52% women). Metabolic changes associated with change in alcohol intake during 6-year follow-up were further examined for 1466 individuals. Alcohol intake was assessed by questionnaires. Circulating lipids, fatty acids and metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics and biochemical assays. Results: Increased alcohol intake was associated with cardiometabolic risk markers across multiple metabolic pathways, including higher lipid concentrations in HDL subclasses and smaller LDL particle size, increased proportions of monounsaturated fatty acids and decreased proportion of omega-6 fatty acids, lower concentrations of glutamine and citrate (P<0.001 for 56 metabolic measures). Many metabolic biomarkers displayed U-shaped associations with alcohol consumption. Results were coherent for men and women, consistent across the three cohorts and similar if adjusting for body mass index, smoking and physical activity. The metabolic changes accompanying change in alcohol intake during follow-up resembled the cross-sectional association pattern (R-2 = 0.83, slope = 0.7260.04). Conclusions: Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardiometabolic risk. The metabolic signature tracks with long-term changes in alcohol consumption. These results elucidate the double-edged effects of alcohol on cardiovascular risk.
Subject: Alcohol
risk factors
metabolomics
fatty acids
metabolic profiling
MENDELIAN RANDOMIZATION ANALYSIS
CARDIOVASCULAR RISK-FACTORS
FATTY-ACIDS
GENOME-WIDE
FINNISH MEN
DISEASE
ASSOCIATION
ATHEROSCLEROSIS
HYPERGLYCEMIA
METAANALYSIS
3142 Public health care science, environmental and occupational health
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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