Metabolic profiling of alcohol consumption in 9778 young adults

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dc.contributor.author Wurtz, Peter
dc.contributor.author Cook, Sarah
dc.contributor.author Wang, Qin
dc.contributor.author Tiainen, Mika
dc.contributor.author Tynkkynen, Tuulia
dc.contributor.author Kangas, Antti J.
dc.contributor.author Soininen, Pasi
dc.contributor.author Laitinen, Jaana
dc.contributor.author Viikari, Jorma
dc.contributor.author Kahonen, Mika
dc.contributor.author Lehtimaki, Terho
dc.contributor.author Perola, Markus
dc.contributor.author Blankenberg, Stefan
dc.contributor.author Zeller, Tanja
dc.contributor.author Mannisto, Satu
dc.contributor.author Salomaa, Veikko
dc.contributor.author Jarvelin, Marjo-Riitta
dc.contributor.author Raitakari, Olli T.
dc.contributor.author Ala-Korpela, Mika
dc.contributor.author Leon, David A.
dc.date.accessioned 2017-03-03T14:21:01Z
dc.date.available 2017-03-03T14:21:01Z
dc.date.issued 2016-10
dc.identifier.citation Wurtz , P , Cook , S , Wang , Q , Tiainen , M , Tynkkynen , T , Kangas , A J , Soininen , P , Laitinen , J , Viikari , J , Kahonen , M , Lehtimaki , T , Perola , M , Blankenberg , S , Zeller , T , Mannisto , S , Salomaa , V , Jarvelin , M-R , Raitakari , O T , Ala-Korpela , M & Leon , D A 2016 , ' Metabolic profiling of alcohol consumption in 9778 young adults ' , International Journal of Epidemiology , vol. 45 , no. 5 , pp. 1493-1506 . https://doi.org/10.1093/ije/dyw175
dc.identifier.other PURE: 80728324
dc.identifier.other PURE UUID: 6db11ad8-5383-4ceb-952a-9a2f2d5fa2cd
dc.identifier.other WOS: 000393184400023
dc.identifier.other Scopus: 84997501050
dc.identifier.other ORCID: /0000-0002-5832-0221/work/31867698
dc.identifier.uri http://hdl.handle.net/10138/176534
dc.description.abstract Background: High alcohol consumption is a major cause of morbidity, yet alcohol is associated with both favourable and adverse effects on cardiometabolic risk markers. We aimed to characterize the associations of usual alcohol consumption with a comprehensive systemic metabolite profile in young adults. Methods: Cross-sectional associations of alcohol intake with 86 metabolic measures were assessed for 9778 individuals from three population-based cohorts from Finland (age 24-45 years, 52% women). Metabolic changes associated with change in alcohol intake during 6-year follow-up were further examined for 1466 individuals. Alcohol intake was assessed by questionnaires. Circulating lipids, fatty acids and metabolites were quantified by high-throughput nuclear magnetic resonance metabolomics and biochemical assays. Results: Increased alcohol intake was associated with cardiometabolic risk markers across multiple metabolic pathways, including higher lipid concentrations in HDL subclasses and smaller LDL particle size, increased proportions of monounsaturated fatty acids and decreased proportion of omega-6 fatty acids, lower concentrations of glutamine and citrate (P<0.001 for 56 metabolic measures). Many metabolic biomarkers displayed U-shaped associations with alcohol consumption. Results were coherent for men and women, consistent across the three cohorts and similar if adjusting for body mass index, smoking and physical activity. The metabolic changes accompanying change in alcohol intake during follow-up resembled the cross-sectional association pattern (R-2 = 0.83, slope = 0.7260.04). Conclusions: Alcohol consumption is associated with a complex metabolic signature, including aberrations in multiple biomarkers for elevated cardiometabolic risk. The metabolic signature tracks with long-term changes in alcohol consumption. These results elucidate the double-edged effects of alcohol on cardiovascular risk. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof International Journal of Epidemiology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Alcohol
dc.subject risk factors
dc.subject metabolomics
dc.subject fatty acids
dc.subject metabolic profiling
dc.subject MENDELIAN RANDOMIZATION ANALYSIS
dc.subject CARDIOVASCULAR RISK-FACTORS
dc.subject FATTY-ACIDS
dc.subject GENOME-WIDE
dc.subject FINNISH MEN
dc.subject DISEASE
dc.subject ASSOCIATION
dc.subject ATHEROSCLEROSIS
dc.subject HYPERGLYCEMIA
dc.subject METAANALYSIS
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Metabolic profiling of alcohol consumption in 9778 young adults en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Quantitative Genetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/ije/dyw175
dc.relation.issn 0300-5771
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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