Fecal calprotectin in juvenile idiopathic arthritis patients related to drug use

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http://hdl.handle.net/10138/176705

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Aalto , K , Lahdenne , P & Kolho , K-L 2017 , ' Fecal calprotectin in juvenile idiopathic arthritis patients related to drug use ' , Pediatric Rheumatology Online Journal , vol. 15 , 9 . https://doi.org/10.1186/s12969-016-0132-2

Title: Fecal calprotectin in juvenile idiopathic arthritis patients related to drug use
Author: Aalto, Kristiina; Lahdenne, Pekka; Kolho, Kaija-Leena
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, Clinicum
Date: 2017-01-31
Language: eng
Number of pages: 7
Belongs to series: Pediatric Rheumatology Online Journal
ISSN: 1546-0096
URI: http://hdl.handle.net/10138/176705
Abstract: Background: Patients with juvenile idiopathic arthritis (JIA) on non-steroidal anti- inflammatory drugs (NSAIDs) may experience abdominal pain. In adults, NSAID use has been linked to an increase in fecal calprotectin (FC) levels, a surrogate marker for gut inflammation. In JIA, data on gut inflammation related to drug use is scarce. Methods: JIA patients followed up at the outpatient pediatric rheumatology clinic in Children's Hospital, Helsinki University Hospital, Helsinki, Finland were routinely assessed for FC if they complained about abdominal pain, had an elevated erythrocyte sedimentation rate (ESR) or used NSAIDs on a daily basis. The FC levels were related to the presence of abdominal pain, to ESR, and to the presence of HLA-B27. Results: Of the total group of 90 patients (median age 9.1 years; 45 JIA patients with disease modifying antirheumatic drugs (DMARDs), 25 without DMARD medication, and 20 arthralgia patients as controls), approximately 50% used NSAIDs, of whom 40% complained about abdominal pain. In patients with abdominal pain, one-third had elevated FC values (>100 mu g/g). The FC values, for the most part, declined along with the discontinuation or reduction of NSAIDs and after intensifying the DMARD medication, where after the pain disappeared. In patients with an elevated ESR, the FC values and ESR normalized in parallel. The presence of HLA-B27 was not associated with FC levels. Conclusion: In patients with JIA and abdominal pain, it may be useful to determine the FC when evaluating the need for further gastrointestinal examinations.
Subject: Abdominal pain
Biological markers
Child
Diagnosis
Gut
IBD
INFLAMMATORY-BOWEL-DISEASE
INDUCED GASTRODUODENAL INJURY
INTESTINAL INFLAMMATION
RHEUMATOID-ARTHRITIS
ENDOSCOPIC FINDINGS
HEALTHY-CHILDREN
ABDOMINAL-PAIN
CROHNS-DISEASE
NSAID USERS
THERAPY
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
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