ADAM23 is a common risk gene for canine idiopathic epilepsy

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Koskinen , L L E , Seppala , E H , Weissl , J , Jokinen , T S , Viitmaa , R , Hanninen , R L , Quignon , P , Fischer , A , Andre , C & Lohi , H 2017 , ' ADAM23 is a common risk gene for canine idiopathic epilepsy ' , BMC Genetics , vol. 18 , 8 . https://doi.org/10.1186/s12863-017-0478-6

Title: ADAM23 is a common risk gene for canine idiopathic epilepsy
Author: Koskinen, Lotta L. E.; Seppala, Eija H.; Weissl, Jutta; Jokinen, Tarja S.; Viitmaa, Ranno; Hanninen, Reetta L.; Quignon, Pascale; Fischer, Andrea; Andre, Catherine; Lohi, Hannes
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Department of Medical and Clinical Genetics
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Faculty of Veterinary Medicine
University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Medicum
Date: 2017-01-31
Language: eng
Number of pages: 5
Belongs to series: BMC Genetics
ISSN: 1471-2156
URI: http://hdl.handle.net/10138/176776
Abstract: Background: Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype with the epilepsy phenotype in eight breeds. Results: GWA analysis did not reveal new epilepsy loci. ADAM23 association (p <0.05) was identified in five breeds. Combined analysis of all eight breeds showed significant association (p = 4.6e(-6), OR 1.9). Conclusions: Our results further support the role of ADAM23 in multiple breeds as a common risk gene for epilepsy with low penetrance. The lack of findings in the GWA analyses points towards inefficient capture of genetic variation by the current SNP arrays, causal variant(s) with low penetrance and possible phenocopies. Future work will include studies on ADAM23 function and expression in canine neurons, as well as whole-genome sequencing in order to identify additional IE genes.
Subject: Dog
Canis familiaris
Epilepsy
Idiopathic epilepsy
ADAM23
GWA
Association
ASSOCIATION ANALYSIS
PREVALENCE
DOGS
PHENOTYPE
LINKAGE
TRAITS
LGI1
3111 Biomedicine
413 Veterinary science
1184 Genetics, developmental biology, physiology
3112 Neurosciences
3124 Neurology and psychiatry
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