Risk of other Cancers in Families with Melanoma : Novel Familial Links

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Frank , C , Sundquist , J , Hemminki , A & Hemminki , K 2017 , ' Risk of other Cancers in Families with Melanoma : Novel Familial Links ' , Scientific Reports , vol. 7 , 42601 . https://doi.org/10.1038/srep42601

Title: Risk of other Cancers in Families with Melanoma : Novel Familial Links
Author: Frank, Christoph; Sundquist, Jan; Hemminki, Akseli; Hemminki, Kari
Contributor: University of Helsinki, Clinicum
Date: 2017-02-15
Language: eng
Number of pages: 7
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/177044
Abstract: A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful information about shared genetic and environmental risk factors and it may be relevant background data in clinical genetic counseling. Using the Swedish Family-Cancer Database, we assessed the relative risk (RR) for any cancer in families with increasing numbers of first-degree relatives diagnosed with melanoma, including multiple melanoma, and in reverse order RR for melanoma in families of multiple discordant cancers. Close to 9% of melanoma was familial; among these 92% were in 2-case families and 8% in families with 3 cases or more. Cancers that were associated with melanoma, in at least two independent analyses, included breast, prostate, colorectal, skin and nervous system cancers. Other associations included cancer of unknown primary, acute myeloid leukemia/myelofibrosis and Waldenstrom macroglobulinemia/myeloma. Significant results, which appear biologically plausible, were also obtained for rare nasal melanoma and mesothelioma. Although small samples sizes and multiple comparisons were of concern, many of the above associations were internally consistent and provide new diverse leads for discordant familial association of melanoma.
3122 Cancers

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