Browsing by Title

Sort by: Order: Results:

Now showing items 12027-12046 of 24406
  • Artto, Ville (Helsingin yliopisto, 2010)
    Migraine is a highly prevalent disease, and despite several important breakthroughs there are still a many questions unanswered in the clinical, genetic and pathophysiological aspects of migraine research. Migraine has been linked to several other diseases such as epilepsy and stroke, but there are still unsolved issues concerning the true nature of these associations. Three genes predisposing to hemiplegic migraine and several loci associated to migraine have been identified, but so far no genes responsible for common forms of migraine have been recognized. Triptans have provided an important step in migraine treatment, but their usefulness in rare forms of migraine have been controversial. The Finnish Migraine Gene Project (FMGP) includes more than 1600 families and 7500 individuals. We evaluated comorbidity from 1000 consecutive subjects in the FMGP. To search for novel loci, we performed a genome-wide linkage scan in 36 families with high prevalences of migraine with visual aura. We collected 76 subjects from the FMGP who suffer from hemiplegic migraine and have used triptans. Finally, to study possible links between stroke and migraine we evaluated the prevalence of migraine in subjects with cervical artery dissection (CAD) and healthy controls. Migraine was associated with increased prevalence of allergy, hypotension and psychiatric diseases. Additionally, men suffering from migraine with aura had increased prevalence of epilepsy and stroke. Further evidence of association between migraine and epilepsy was found in our linkage study. The parametric two-point linkage analysis showed significant evidence of linkage between migraine aura and a locus on 9q21-q22. Interestingly, the same locus has been associated with occipitotemporal epilepsy. CAD seems to be a migraine risk factor, and therefore a link between stroke and migraine. Notably, CAD seems to alleviate migraine activity further indicating the association between these two conditions. Despite the contraindications of triptans, it seems that they are safe and effective in the abortive treatment of hemiplegic migraine.
  • Paraczky, Anna (2014)
    The multidimensional and in many ways problematic reception of asylum seekers and refugees in Malta creates an interesting research area. Malta is an island located in-between the two continents of Europe and Africa and has due to its location become part of one of the current major migration routes. This study is about the daily life realities of residents living at Marsa Open Centre, their thoughts about starting their lives again in Malta as well as the challenges they face along the way. The study was conducted with an exploratory approach, using elements to guide the process from resilience and ecological perspective. The data was collected by conducting semi-structured interviews with nine residents of Marsa Open Centre which was further analysed with content analysis. Results show that residents are given a framework for their stay at Marsa Open Centre in which they try their best to manage. Friends and family members are a relevant source of support. The main way of “making it” seems to be finding employment, for which being able to attend relevant education is seen important. There are elements of support from social work professionals that help residents better manage their situation. A hopeful mindset towards the future is present. Challenges include financial struggles creating constant daily obstacles. Life at Marsa Open Centre is a challenge itself. Residents felt they are not given enough information and that they have to struggle with unfair bureaucracy. Many have also experienced unfortunate racist encounters. The residents’ ability and will to manage in the present is not always purely dependent on themselves, but is often restricted and dependent on their surroundings. Nevertheless, residents showed resilience while being surrounded with new difficulties, continuing their quest to reach a life where they could become free from restrictions and live independently.
  • Korhonen, Kukka (2012)
    The European Union has agreed on implementing the Policy Coherence for Development (PCD) principle in all policy sectors that are likely to have a direct impact on developing countries. This is in order to take account of and support the EU development cooperation objectives and the achievement of the internationally agreed Millennium Development Goals. The common EU migration policy and the newly introduced EU Blue Card directive present an example of the implementation of the principle in practice: the directive is not only designed to respond to the occurring EU labour demand by attracting highly skilled third-country professionals, but is also intended to contribute to the development objectives of the migrant-sending developing countries, primarily through the tool of circular migration and the consequent skills transfers. My objective in this study is to assess such twofold role of the EU Blue Card and to explore the idea that migration could be harnessed for the benefit of development in conformity with the notion that the two form a positive nexus. Seeing that the EU Blue Card fails to differentiate the most vulnerable countries and sectors from those that are in a better position to take advantage of the global migration flows, the developmental consequences of the directive must be accounted for even in the most severe settings. Accordingly, my intention is to question whether circular migration, as claimed, could address the problem of brain drain in the Malawian health sector, which has witnessed an excessive outflow of its professionals to the UK during the past decade. In order to assess the applicability, likelihood and relevance of circular migration and consequent skills transfers for development in the Malawian context, a field study of a total of 23 interviews with local health professionals was carried out in autumn 2010. The selected approach not only allows me to introduce a developing country perspective to the on-going discussion at the EU level, but also enables me to assess the development dimension of the EU Blue Card and the intended PCD principle through a local lens. Thus these interviews and local viewpoints are at the very heart of this study. Based on my findings from the field, the propensity of the EU Blue Card to result in circular migration and to address the persisting South-North migratory flows as well as the relevance of skills transfers can be called to question. This is as due to the bias in its twofold role the directive overlooks the importance of the sending country circumstances, which are known to determine any developmental outcomes of migration, and assumes that circular migration alone could bring about immediate benefits. Without initial emphasis on local conditions, however, positive outcomes for vulnerable countries such as Malawi are ever more distant. Indeed it seems as if the EU internal interests in migration policy forbid the fulfilment of the PCD principle and diminish the attempt to harness migration for development to bare rhetoric.
  • Aurela, Birgit (Helsingin yliopisto, 2001)
  • Övermark, Lassi (2015)
    Migreeniin on yhdistetty useita liitännäissairauksia, joista tässä tutkimuksessa keskityttiin erityisesti astmaan ja allergioihin. Tutkimuksen tavoitteena oli selvittää, ovatko allergiat ja astma yleisempiä migreenisukujen migreenipotilailla kuin heidän terveillä perheenjäsenillään ja miten ne vaikuttavat migreenin kliiniseen kuvaan. Tavoitteena oli myös löytää sukuja molekyyligeneettisiin jatkotutkimuksiin, joissa etsitään mahdollisia yhteisiä tekijöitä migreenin ja allergioiden tai astman välillä. Lisäksi haluttiin selvittää, voisiko joku aiemmin koko genomin kattavassa meta- analyysissä tunnistetuista 12 yhden nukleotidin polymorfismeista (SNP) assosioitua myös migreenipotilaiden allergiaan ja astmaan. Tutkimus on toteutettu kyselylomaketutkimuksena, johon on osallistunut 10061 suomalaista migreenipotilasta ja heidän perheenjäsentään. Migreenipotilailla esiintyy allergiaa merkittävästi enemmän kuin heidän terveillä perheenjäsenillään, 35,5% vs 24,4%, samoin kuin astmaa, 9,7% vs 7,3%. Migreenipotilaista allergikoilla ja astmaatikoilla päänsärkykohtauksia oli useammin ja ne kestivät kauemmin, kuin allergiattomilla ja astmattomilla. Allergikkojen päänsärky oli lisäksi keskimäärin voimakkaampaa. Jatkotutkimuksiin valittiin sukuja, joissa allergiat ja migreeni vaikuttavat periytyvän yhdessä jopa kolmessa sukupolvessa. Aiemmin tunnistetuista SNP:istä rs2274316 (MEF2D-geenissä) näyttäisi liittyvän migreenipotilaiden allergiaan (p=0,025).
  • Vuola, Pietari (2014)
    Migreeni on aivoinfarktin riskitekijä nuorella iällä. Sairauksien yhteyteen liittyvien mekanismien selvittäminen on tärkeää riskipotilaiden paremman tunnistamisen kannalta. Tämän tutkimuksen tavoitteena oli selvittää migreenin kliininen kuva aivoinfarktin sairastaneilla migreenipotilailla ja verrata sitä aivoinfarktia sairastamattomien potilaiden migreeniin. Tutkimus perustui kyselylomakkeiden välityksellä kerätyn datan tilastolliseen analysointiin. Migreenin kliinisiä piirteitä verrattiin alle 50-vuotiaana aivoinfarktin saaneiden migreenipotilaiden muodostaman tapausryhmän (n=45) ja aivoverenkiertohäiriöitä sairastamattomien migreenipotilaiden muodostaman verrokkiryhmän (n=4178) välillä. Kummastakin potilasryhmästä otettiin myös erikseen vertailuun aurallista migreeniä sairastavat potilaat (n=33 ja n=2083). Tapauksissa oli enemmän aurallista migreeniä sairastavia kuin verrokeissa (p=0,0064). Migreenikohtaustiheys oli keskimäärin pienempi tapausryhmäläisillä (p=0,0117). Tapauksilla yleisempää oli toispuoleinen päänsärky (p=0,0006), sykkivä päänsärky (p<0,0001) ja kohtauksenaikainen oksentelu (p=0,0013). Ruoanhimo migreenin esioireena oli harvinaisempaa tapauksilla kuin verrokeilla (p=0,012). Aurallisten potilasryhmien vertailussa visuaalisen migreeniauran sahalaita oli yleisempää tapauksilla kuin verrokeilla (p=0,0198). Muut aurallisen vertailun merkittävät tulokset olivat samoja kuin yleisessä vertailussa. Aivoinfarktin nuorena saaneiden potilaiden migreenin erityispiirteet saattavat liittyä kohonneeseen aivoinfarktiriskiin. Jatkotutkimuksille on aihetta.
  • Vuola, Pietari (2014)
    Migreeni on aivoinfarktin riskitekijä nuorella iällä. Sairauksien yhteyteen liittyvien mekanismien selvittäminen on tärkeää riskipotilaiden paremman tunnistamisen kannalta. Tämän tutkimuksen tavoitteena oli selvittää migreenin kliininen kuva aivoinfarktin sairastaneilla migreenipotilailla ja verrata sitä aivoinfarktia sairastamattomien potilaiden migreeniin. Tutkimus perustui kyselylomakkeiden välityksellä kerätyn datan tilastolliseen analysointiin. Migreenin kliinisiä piirteitä verrattiin alle 50-vuotiaana aivoinfarktin saaneiden migreenipotilaiden muodostaman tapausryhmän (n=45) ja aivoverenkiertohäiriöitä sairastamattomien migreenipotilaiden muodostaman verrokkiryhmän (n=4178) välillä. Kummastakin potilasryhmästä otettiin myös erikseen vertailuun aurallista migreeniä sairastavat potilaat (n=33 ja n=2083). Tapauksissa oli enemmän aurallista migreeniä sairastavia kuin verrokeissa (p=0,0064). Migreenikohtaustiheys oli keskimäärin pienempi tapausryhmäläisillä (p=0,0117). Tapauksilla yleisempää oli toispuoleinen päänsärky (p=0,0006), sykkivä päänsärky (p<0,0001) ja kohtauksenaikainen oksentelu (p=0,0013). Ruoanhimo migreenin esioireena oli harvinaisempaa tapauksilla kuin verrokeilla (p=0,012). Aurallisten potilasryhmien vertailussa visuaalisen migreeniauran sahalaita oli yleisempää tapauksilla kuin verrokeilla (p=0,0198). Muut aurallisen vertailun merkittävät tulokset olivat samoja kuin yleisessä vertailussa. Aivoinfarktin nuorena saaneiden potilaiden migreenin erityispiirteet saattavat liittyä kohonneeseen aivoinfarktiriskiin. Jatkotutkimuksille on aihetta.
  • Häyhä, Leila (1991)
  • Karvonen, Ulla (Helsingin yliopisto, 2011)
    In the study, two upper elementary school health education textbooks were investigated. The purpose of the study was to examine the health discourses and subject- and reader positions constructed in text. Theoretically, the study is based on poststructuralist thought and critical sociology of health promotion. Methodologically, it draws mainly on critical lingvistics and new rhetorics. Textbooks were understood as informative, argumentative and persuasive texts in which different lexical and grammatical methods to secure the readers´ responsiveness were utilized. Also, the relations of the text to wider genres, social situations, structures, institutions and practices were investigated. The interpersonal and ideational dimensions of the texts were analysed with the aim of finding out the kinds of identities for and relations between the speaker and the ideal reader were constructed and the kinds of representations of health and the world around were produced in the textbooks. Multiple discourses of health, and genres and styles characteristic for many kinds of contexts and situations were found. The identities of and the relationships between the speaker and the ideal reader of the text were also multiple and changing. The text echoes both biomedical health discourse emphasizing prevention of illness and holistic discourse emphasizing personal welfare, fulfillment and happiness. Furthermore, traces for example from development psychological, ecological and civilization critical discourses were perceived. Formal scientific genre was found to be mixed with informal chatting imitating close and equal relationship between participants characteristic for advertisements and other persuasive texts, and obliging and ordering expression typical for school context and other situations where the relationship between participants is unequal and distant. The ideal reader of the text can be characterized as adolescent living in the world saturated by advertising and media. He or she is interested in the life of the celebrities, and is interested rather in her or his appearance, image and short-term enjoyment than health and long-term welfare. In the textbooks, healthy way of life is attempted to create a product which appeals to the values and interests of the imaginary public, the ideal reader of the text. Marketing healthy choices tend to reproduce stereotyped ideas of happiness, good life, youth and sex. Furthermore, individualizing approach mixed with wide definition of health legitimizes easily an erraneous impression of health, beauty and success being personal achievements dependent only on attitudes and competences.
  • Jauhiainen, Marjukka (1928)
  • Juntunen, Arja (1973)
  • Eriksson, Ritva (1988)
  • Lievonen, Mauri (1985)
  • Kamppi-Nyholm, Nina (1985)