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  • Ullah, Mohammad Wali (Helsingin yliopisto, 2014)
    Gallium nitride (GaN) has emerged as one of the most important semiconductors in modern technology. GaN-based device technology was mainly pushed forward by invention of p-type doping and the successful fabrication of light emitting diodes (LEDs) and laser diodes (LDs). Intensive studies in the last 20 years on GaN have significantly advanced the understanding of the properties and have expanded the range of practical applications. Beside basic lighting, current applications of GaN include high-power and high temperature electronics, microwave, optoelectronic devices, and so on. The successful production of optical devices demands efficient tuning of charge carrier lifetime where defect engineering plays a vital role. During growth, varying the level of recombination centers is difficult, whereas ion irradiation can do this job efficiently on a final product. On the other hand, during doping, undesirable defects can also be produced and epitaxial GaN is known to have a highly defective structure. Thus, having both positive and negative aspects, it is very important to have a detailed understanding of irradiation-induced defects. To explain experimental findings, atomic level understanding is necessary, but it is not always possible to have an atomistic view of defect dynamics in experiments. Some damage build-up studies by single ions have been reported in the literature, but not many by molecular ions. In this thesis, the irradiation of GaN by single and molecular ions by the means of atomistic simulations was studied. Detailed analysis mainly of what kind of defects, their distribution, reason of defect formation and time evolution have been studied and compared with experiments. The irradiation response of both bulk and nano-structured GaN system were studied. For bulk studies, all projectiles were irradiated having the same energy per mass. The damage by molecular ions showed strong dynamic annealing. No non-linearity had been observed in the total number of point defects between single and molecular ions. On the other hand, molecular ions produce larger clusters of point defects than single ions. These large defect clusters can be one of the mechanisms of the experimentally observed faster carrier decay time for molecular projectiles. Defects were mostly concentrated at the surface and near surface regions, which is also evident from experiments. Comparison between a similar mass single ion and a molecular ion show that a single ion produced more defect clusters than molecular ions. This suggests that heavy ions are even more efficient than similar mass cluster ions to quench the carrier lifetime. Irradiation of a GaN nanowire (NW) reveals that a large surface to volume ratio promotes high density of surface defects. The experimentally observed yellow luminescence band is correlated with these defect induced surface states. Irradiation induced defects also expand the lattice parameters of the NW.
  • Lasa Esquisabel, Ane (Helsingin yliopisto, 2014)
    The world's energy demand and harmful green-house gas emissions are continuously increasing, while the fossil fuel reservoir may soon end. Currently, there is no clear alternative to the traditional energy production methods for a safe and clean future. Fusion could be part of the solution offering a green-house gas free, virtually endless, safe and large scale energy production. A major challenge for fusion is, however, to produce more energy than needed to achieve and maintain the fusion reaction. The most feasible fusion reaction is based on two hydrogen isotopes: deuterium and tritium, which fuse to produce a helium atom and a neutron. For these atoms to fuse, they must overcome the repulsive interaction between them, requiring extreme temperatures. Thus, the particles ionize forming gas plasma. On Earth, this condition can only be met by isolating the plasma from its environment, for instance, by using closed magnetic fields to form a torus-like shaped plasma, also known as tokamak. However, the plasma particles will interact with the reactor walls as their confinement is never perfect, the exhausted plasma must leave the reactor and impurities are introduced in the plasma boundary to control its characteristics. The plasma-wall interactions are especially intense at the divertor, where the plasma is designed to touch the wall. Understanding these processes is essential to develop safe, long-lasting materials and to avoid contaminating the plasma fuel. The main candidates as first wall materials in future fusion reactors are beryllium for the main wall, and tungsten and carbon for the divertor. Also, the materials may mix due to wall erosion, transport of the eroded particles and their deposition in a new location. Plasma-wall interactions can be studied in current experimental reactors or in linear plasma devices. However, this work is often insufficient to understand the underlying mechanisms. Further, the effects of plasma-wall interactions in materials develop in a wide range of time and length scales. Multi scale modelling is a tool that allows to overcome these challenges, improving the predictions for future fusion reactors. In this thesis, the plasma wall interactions taking place in a fusion reactors divertor have been studied by computational means. The interaction of pure and mixed divertor materials, with plasma and impurity particles were modelled. The work was mainly based on atomistic scale calculations, and a Kinetic Monte Carlo algorithm has also been developed to extend the results to macroscopic scales, enabling a direct comparison with experiments. First, deuterium irradiation of various W-C composites has been modelled, focusing on deuterium implantation, variations of the substrate composition and C erosion mechanisms. Carbon was preferentially eroded, varying the substrate's composition throughout the irradiation. The presence of carbon also affected the D implantation characteristics. As carbon became less likely to be an ITER first wall material, the present work focused on the tungsten-beryllium-deuterium system. The tungsten-beryllium mixing showed a strong dependence on irradiation energy and angle. Further, the presence of Be led to higher fuel implantation and W erosion was suppressed by mixed layer formation. The obtained yields were compared to Binary Collision Approximation results, in order to improve the description of the latter method. Furthermore, an unexpected and possibly harmful phenomenon has been addressed in this thesis: porous nano-morphology formation in tungsten by helium plasma exposure. First, the main characteristics and active mechanisms in the system were identified by atomistic simulations. Then, the porous morphology growth was modelled by implementing these processes in a Kinetic Monte Carlo code, resulting in rates that agreed with experimental findings. A morphology growth model was derived where the time dependence is driven by the evolution of the surface roughness, which is a stochastic process and thus evolves as the square root of time.
  • Parviainen, Stefan (Helsingin yliopisto, 2014)
    Modern society runs largely on electricity, and where there is electricity there are electric fields. As the boundaries of technology are pushed forward, stronger and stronger electric fields are either required, or appear due to unwanted effects. Examples of such applications, where very high electric fields are utilised include particle accelerators and atom probes. To further be able to improve on such techniques, it is necessary to gain a good understanding of the processes that are involved. Because it is often difficult, if not impossible, to observe these processes with high resolution in experiments, one needs to consider the use of atomistic simulations instead. This thesis provides an extension to classical molecular dynamics by describing an implementation where several electronic effects are considered when dealing with metal surfaces under high electric fields. These effects include the charging of surface atoms, field electron emission and the resulting resistive heating, as well as field evaporation of both neutral and charged atoms. In addition to the implementation details, the thesis also contains a brief background of the physics involved in these processes. Using the implementation, it is observed that a surface protrusion may grow on an initially flat surface in the presence of a near-surface void when a strong external electric field is applied. The growth is very rapid, resulting finally catastrophic breakage. This mechanism may explain the appearance of field emitters on otherwise pristine samples, and the instability of measured field emission currents. Simulations also reveal that high aspect ratio protrusions are subject to Rayleigh instability due to the temperature rise caused by field electron emission currents. As a result a large fraction of the protrusion can break off. The model also allows for the study of the trajectories of field evaporated ions from a surface, as they are accelerated in the electric field. From the simulations we see that even changes in the surface morphology on the atomic scale may result in aberrations in atom probe tomography experiments.
  • Leino, Aleksi (Helsingin yliopisto, 2015)
    Ions in the keV energy range are regularly used in the semiconductor industry for device fabrication. Irradiation with ions of higher energies can also induce favorable structural changes in the irradiated samples. Among these, irradiation effects of the so-called swift heavy ions (SHIs, heavy ions with specific energies in the 1 MeV / amu range) in electrically insulating materials are particularly interesting. Despite the wide range of existing applications (filters, printed circuit boards and geological dating) and application potential (fuel cells, cell mimicking membranes) of SHI irradiation, the mechanisms by which SHIs interact with insulators are still under debate. Modelling of SHIs is a very challenging task as, contrary to ions with lower energies, they mostly interact with electrons, inducing lots of electronic excitations. Incorporating the latter with atomistic dynamics is especially difficult in insulators, and the methods have not yet been fully established. SHIs can induce a cylindrical region of structural transformation known as an ion track. In crystalline silicon dioxide, a track consists of an amorphized region that is typically several microns long and has a radius of less than ten nanometers. Furthermore, it was recently found out that SHI irradiation can be used to induce a shape transformation in metal nanoclusters (NCs) that are embedded in amorphous silicon dioxide. Spherical NCs (radius 1-50 nm) elongate along the ion beam direction and are shaped into nanorods or prolate spheroids. The phenomenon can be exploited to produce large arrays of equally aligned nanoclusters within a solid substrate, which is difficult to achieve otherwise. In this thesis, ion track formation and the elongation of gold nanoclusters in silicon dioxide are studied using so called two-temperature molecular dynamics simulations. The structure of the tracks is studied and a mechanism is proposed for the nanoparticle elongation effect. The work presented here is a step towards the understanding of SHI related effects in a broader range of insulating materials for the SHI based applications.
  • Avchaciov, Konstantin (2015)
    Rapid technological development motivates the research community to find out new processing technologies for producing materials with unique properties. Production of new materials or improving the existing ones requires development of new methods, which sometimes involves processing under far-from-equilibrium conditions. Usually underlying physical processes, taking place during such processing, are not well known. Understanding them is the key to the enhancement of processing methods. This thesis covers only a tiny part of a huge number of problems existing in the material science. The studies done here could be useful for solving the problem of metallic glass brittleness and for further development of the ion beam technology for controlling magnetic properties of thin films. Discussion on the pathway of the self-propagating high-temperature synthesis in multilayer metallic films was also included in the thesis We studied the effect of ion irradiation on Cu64Zr36 metallic glass by means of molecular dynamics (MD). Low-energy ion irradiation of metallic glass produces damage zones, where the local structure of glass differs from the structure of pristine glass. These changes are independent on ion energy and flux due to the possibility of partial recovery during cascade relaxation. However, the size of the damage zones could be controlled by varying the dose of ions. This makes possible the production of either isolated damaged regions or homogeneously damaged glass. We showed that mechanical properties of the glass strongly depend on the local structure. In damage zones, the specific arrangement of the structural units is destroyed. This promotes the formation of many shear transformation zones in the damaged area, when a mechanical load is applied. It results in enhanced plasticity of the irradiated glass. Our research indicates that ion irradiation could be used for the softening of brittle metallic glasses for preventing formation of cracks in them. Atomistic studies of the reaction pathway in the multilayer Ru/Al films were done to interpret the results from X-ray diffraction measurements. The MD simulations covered the first nanoseconds; at this timescale, no information about the reaction pathway could be obtained from the experimental methods. The MD simulations demonstrated simultaneous Ru dissolution into liquid Al and $B2$ RuAl phase nucleation at the Ru/Al interface. Our results agreed well with experimental observations, and, moreover, helped to refine understanding of the X-Ray diffractograms. We also studied structural modifications of Pt/Co/Pt trilayer films, which could explain appearance of the perpendicular magnetic anisotropy (PMA) after irradiation with Ga+ ions. Molecular dynamics and Monte Carlo (MD-MC) simulations were performed to find changes in the long range order and short range order, associated with ion irradiation. The results of our simulations showed that the separated metal layers containing Pt and Co were intermixed and formed the new solid solution. This solution was chemically disordered at the nanosecond time scale. With combined MD-MC simulations, we showed that the transition between chemically ordered and disordered phases was possible. The fractions of the ordered phases grew monotonously with an ion dose due to the ongoing process of ion-beam mixing. However, assuming the correlation between the magnetic properties of the film and the fraction of the chemically ordered CoPt phase in it, this result cannot explain the disappearance of PMA at the high doses. The strain analysis showed that the Co layer exhibited tensile strain in the lateral direction at the moderate doses, where the PMA was detected. We explained the appearance of strains by changing of the thickness of the hcp-Co layer right inside the trilayer Pt/Co/Pt structure, which was possible due to its partial transformation to the fcc structure. Below the critical size of the hcp layer, the strain inside it appears, which, in our opinion, could cause the appearance of PMA at the moderate doses and the disappearance of PMA at the high doses.
  • Paloheimo, Marja Riitta (2000)
    Tutkielma käsittelee Suomen ensimmäisen ydinvoimalan hankintaprosessia poliittisena kysymyksenä. Atomiasiassa soudettiin ja huovattiin 1965-1969. Tutkielman tavoitteena on selvittää, miksi päätöksen tekeminen kesti niin kauan, mikä oli presidentti Urho Kekkosen rooli hankinnassa, liittyikö hankinta suomettumiseksi kutsuttuun ilmiöön sekä, mitkä tekijät lopulta ratkaisivat tilauksen. Imatran Voima Osakeyhtiö (IVO) käynnisti ensimmäisen tarjouskierroksen ydinvoimalan hankkimiseksi vuonna 1965. Samoihin aikoihin myös Suomen teollisuuden edustajat pohtivat omassa piirissään ydinvoiman rakentamismahdollisuuksia. Valtioneuvosto ei kuitenkaan hyväksynyt IVOn edullisimmaksi toteamaa vaihtoehtoa, saksalaista AEG:tä, vaan päätti jättää laitoksen tilaamatta saatujen tarjousten perusteella keväällä 1967. Jotta asiassa päästäisiin uudelleen liikkeelle, valtioneuvosto tilasi teollisuuden edustajista koostuneelta Suomen Atomiteollisuusryhmältä tutkimuksen, jossa selvitettiin teollisuuden mahdollisuuksia osallistua IVOn ydinvoimalan rakentamiseen. Vaikka asiaa ei julkisuudessa mainostettukaan, käytännössä tästä alkoi toinen tarjouskierros. Toisella kierroksella tilauksesta kilpailivat ruotsalainen Asea, englantilainen UKAEA sekä neuvostoliittolainen Technopromexport. Saksalainen vaihtoehto oli jäänyt pois. Tarjouskierroksen liikkeellelähtö oli epäselvä. Ei tiedetty, kuka asiaa johti tai missä oltiin menossa. Tarjoajat eivät kaihtanet keinoja kaupatessaan laitoksiaan, sillä jokaisella mukanaolijalla oli tarve saada tuotteensa myydyksi rajojensa ulkopuolelle referenssilaitokseksi. Suurin myyntitarve oli Neuvostoliitolla. Kesällä 1968 itänaapuri pudotti tarjouksensa hintaa lähes 30 prosenttia, kun se ensin oli saanut suomalaisilta muiden kilpailijoiden hintatiedot. Oltiin taas tilanteessa, jossa valtioneuvoston oli vihellettävä pelin poikki kauppapoliittisen selkkauksen välttämiseksi. Kolmannella kerralla laitoshankintaneuvottelut aloitettiin suoraan Neuvostoliiton kanssa ilman julkisuutta. Muilta tarjoajilta ei enää kysytty. Kesällä 1969 laitos päätettiin tilata Neuvostoliitosta. Tutkielmassa osoitetaan, että Suomi joutui kovan painostuksen kohteeksi asiassa, josta kenelläkään, ei Suomella sen enempää kuin muillakaan, ollut kokemusta. Selkeitä pelisääntöjä ei ollut. Tämä selittää osaltaan pitkään kestänyttä kaupanhierontaa. Presidentti Kekkonen, vaikka osallistui kauppaan välillä aktiivisestikin, ei lopulta tehnyt asiassa päätöstä yksin, kuten dosentti Hannu Rautkallio on esittänyt. Tutkielmassa osoitetaan, että suomalaiset rikkoivat räikeästi reilun pelin sääntöjä kertomalla yhdelle kilpailijalle muiden kilpailijoiden luottamuksella antamia tarjoustietoja. Silti suomettumisesta voidaan puhu kaupan osalta vain tietyiltä osin. Keskeisimpinä lähteinä tutkielmassa on käytetty laitoshankinnan käsittelyyn osallistuneiden ministereiden ja virkamiesten arkistoihin jättämiä muistioita ja kirjeenvaihtoa. Lisäksi lähteenä on käytetty tapahtumiin osallistuneiden muistelmia ja haastatteluita. Sanomalehtiä on käytetty julkisen kuvan ja joidenkin muistelmissa esiintyneiden ajoituksellisten ristiriitojen selvittämiseen. Vaikka poliittisista kuvioista on kirjoitettu lukuisia kirjoja ja artikkeleita, asiaa ei ole selvitetty aikaisemmin historian tutkimuksen keinoin.
  • Margaritis, Mihalitsa (2013)
    Koiran atooppinen dermatiitti (atopic dermatitis, AD) on yleinen ja pitkäaikainen kutiseva inflammatorinen ihosairaus. Sairautta ei voida parantaa, mutta oireita voidaan lievittää. Hoito on pitkäaikainen, usein jopa elinikäinen. Riittävän vasteen saavuttamiseksi joudutaan usein yhdistämään eri hoitoja. Hoitovaihtoehtojen valitsemiseen vaikuttavat hoidon tehokkuuden ja hinnan lisäksi hoidon turvallisuus. Glukokortikoidit tarjoavat tehokkaan ja uudempiin lääkkeisiin verrattuna taloudellisesti edullisen hoitovaihtoehdon. Glukokortikoidien käyttö aiheuttaa omistajissa kuitenkin pelkoa, sillä niiden pitkäaikaiskäytön turvallisuudesta ei ole tehty kattavia tutkimuksia. Kirjallisuuskatsauksen tavoitteena oli koota tärkeimmät koiran AD:n hoitovaihtoehdot, syventyä glukokortikoidien kliiniseen käyttöön ja selvittää, onko pitkäaikainen systeeminen anti-inflammatorinen glukokortikoidilääkitys turvallista. Koiran AD:n hoidossa ensisijaisesti pyritään välttämään oireita aiheuttavia allergeeneja. Tämä on käytännössä useimmiten vaikeaa tai mahdotonta. Tällöin on suositeltavaa kokeilla siedätyshoitoa, mikäli allergeenit on tunnistettu. Siedätyshoito ei kuitenkaan aina ole riittävä lievittämään oireita, jolloin hoitona voidaan käyttää akuuttia kutinaa ja inflammaatioreaktiota tehokkaasti vähentäviä glukokortikoideja tai kalsineuriini-inhibiittoreita. Antihistamiinit saattavat lisäksi osalla koirista lievittää oireita, mutta ne eivät tehoa akuuttiin kutinaan. Välttämättömillä rasvahapoilla ja ihoa kosteuttavilla tukihoidoilla pyritään parantamaan ihon eheyttä sekä vähentämään allergeenien ja hilseen määrää iholla. Koska AD:sta kärsivillä koirilla ihoinfektiot ovat tavallista yleisempiä, voi desifioivista topikaalisista puhdistusaineista, puhdistuspyyhkeistä tai shampoovalmisteista olla hyötyä. Tarvittaessa yleistyneissä tai syvissä ihoinfektioissa tulee hoitoon kombinoida systeeminen mikrobilääkitys. Liiallisella glukokortikoidien saannilla on lukuisia haittavaikutuksia, jotka on tunnettu jo kymmenien vuosien ajan. Sivuvaikutukset koirilla ovat moninaisia ja vaihtelevat lievistä vakaviin. Sivuvaikutusten riski kasvaa annoksen kasvaessa ja hoidon pitkittyessä sekä käytettäessä voimakkaampia valmisteita, mutta joitakin sivuvaikutuksia tavataan myös anti-inflammatorisella annoksella. Anti-inflammatoriseen glukokortikoidihoitoon keskittyviä kattavia turvallisuustutkimuksia on kuitenkin hyvin vähän ja tutkimustulokset ovat osittain ristiriitaisia. Lisäksi suurimmassa osassa tutkimuksia sivuvaikutuksia on tutkittu ihmisillä, joten tuloksia ei voida suoraan yleistää koiriin. Lopullisia johtopäätöksiä pitkäaikaisen anti-inflammatorisen glukokortikoidihoidon ja monien sivuvaikutusten välisistä yhteyksistä on vaikea tehdä. Täysin turvallisesta minimiannoksesta tai hoidon kestosta ei ole näyttöä, minkä vuoksi tulisi aina käyttää matalinta tehokasta annosta. Pitkäaikaisen anti-inflammatorisen glukokortikoidilääkityksen aiheuttamista vakavista haittavaikutuksista ei kuitenkaan vaikuta olevan selkeää näyttöä koirilla. Tutkimustulokset viittaavat siihen, ettei pitkäaikainen anti-inflammatorinen glukokortikoidihoito aiheuta dramaattisia sivuvaikutuksia ja että hoitoon liittyvä pelko saattaa olla liioiteltu.
  • Kauppinen, Jari (Helsingin yliopisto, 2000)
  • Lahelma, Antti (Suomen Muinaismuistoyhdistys r.y, 2008)
    Approximately 125 prehistoric rock paintings have been found in the modern territory of Finland. The paintings were done with red ochre and are almost without exception located on steep lakeshore cliffs associated with ancient water routes. Most of the sites are found in the central and eastern parts of the country, especially on the shores of Lakes Päijänne and Saimaa. Using shore displacement chronology, the art has been dated to ca. 5000 – 1500 BC. It was thus created mainly during the Stone Age and can be associated with the so-called ‘Comb Ware’ cultures of the Subneolithic period. The range of motifs is rather limited, consisting mainly of schematic depictions of stick-figure humans, elks, boats, handprints and geometric signs. Few paintings include any evidence of narrative scenes, making their interpretation a rather difficult task. In Finnish archaeological literature, the paintings have traditionally been associated with ’sympathetic’ hunting magic, or the belief that the ritual shooting of the painted animals would increase hunting luck. Some writers have also suggested totemistic and shamanistic readings of the art. This dissertation is a critical review of the interpretations offered of Finnish rock art and an exploration of the potentials of archaeological and ethnographic research in increasing our knowledge of its meaning. Methods used include ’formal’ approaches such as archaeological excavation, landscape analysis and the application of neuropsychological research to the study of rock art, as well as ethnographically ’informed’ approaches that make use of Saami and Baltic Finnish ethnohistorical sources in interpretation. In conclusion, it is argued that although North European hunter-gatherer rock art is often thought to lie beyond the reach of ‘informed’ knowledge, the exceptional continuity of prehistoric settlement in Finland validates the informed approach in the interpretation of Finnish rock paintings. The art can be confidently associated with shamanism of the kind still practiced by the Saami of Northern Fennoscandia in the historical period. Evidence of similar shamanistic practices, concepts and cosmology are also found in traditional Finnish-Karelian epic poetry. Previous readings of the art based on ‘hunting magic’ and totemism are rejected. Most of the paintings appear to depict experiences of falling into a trance, of shamanic metamorphosis and trance journeys, and of ‘spirit helper’ beings comparable to those employed by the Saami shaman (noaidi). As demonstrated by the results of an excavation at the rock painting of Valkeisaari, the painted cliffs themselves find a close parallel in the Saami cult of the 'sieidi', or sacred cliffs and boulders worshipped as expressing a supernatural power. Like the Saami, the prehistoric inhabitants of the Finnish Lake Region seem to have believed that certain cliffs were ’alive’ and inhabited by the spirit helpers of the shaman. The rock paintings can thus be associated with shamanic vision quests, and the making of ‘art’ with an effort to socialize the other members of the community, especially the ritual specialists, with trance visions. However, the paintings were not merely to be looked at. The red ochre handprints pressed on images of elks, as well as the fact that many paintings appear ’smeared’, indicate that they were also to be touched – perhaps in order to tap into the supernatural potency inherent in the cliff and in the paintings of spirit animals.
  • Malyutin, Kirill (Helsingin yliopisto, 2015)
    The main objective was to identify and analyze the tourism management perspective to Corporate Social Responsibility (CSR) at the luxury Fairmont Chateau Lake Louise (FCLL) Hotel and Resort in the Banff National Park (NP). It is viable for a company to conduct responsible business operations, especially in protected areas, because of a great influence of Environmental Non-Governmental Organizations (ENGO’s) and high customer awareness of environmental issues. Definitely, large chains of luxury hotels and resorts, such as the Fairmont, are greatly dependent on their reputation and engagement with the communities’ well-being and handling the environmental issues in the area of business operations. The thesis is divided into several parts, i.e. introduction, theoretical background, methodology and previous research, results of the research, and conclusions and discussions. Undoubtedly, all of the above mentioned parts are essential in order to get a complete picture of the thesis topic and its achieved objectives. As a matter of fact, the current Master’s thesis comprises various industries with hospitality, tourism, and forestry. In order to gain the stated objectives, a deep analysis of the literature related to the topic and online sources was conducted, as well as email interviews with some representatives, i.e. certain managers, of the FCLL. Obviously, not all of the respondents were able to answer in time or to answer at all due to various reasons; however, the received replies were enough to make their contribution to the current thesis. The questions were especially designed to fit the respondents and to get a better insight into the FCLL’s business activities in the Banff NP. As the results showed, the FCLL has a good reputation due to its dedication and achievements, regardless of the plans to build a conference center and previous negative impact on the environment in the area. FCLL is trying its best to become a good “citizen” by following its CSR practices and engaging stakeholders. The FCLL’s major focus is to diminish negative impacts from its business operations in the park, i.e. on its various environmental programs, engaging not only personnel of the company, but communities and customers. These results were used as a basis of a SWOT analysis to have a clearer and visible representation of the FCLL’s current position, taking all the issues into consideration. In conclusion, this research shows that the luxury Fairmont Chateau Lake Louise Hotel and Resort in the Banff National Park has a good image and reputation due to its various environmental programs, dedication to its responsible business operations, and engagement of the involved stakeholders; therefore, it is clear the company has a great potential based on its achievements and willingness to make its positive contribution.
  • Myllymäki, Tuija (1992)
    Supistuessaan lihassolu käyttää energianlähteenä ATP:a, jonka konsentraatio lihaksessa siten laskee rasituksen aikana. Samalla kertyy ATP:n hajoamistuotteita lihakseen ja verenkiertoon. Tässä tutkimuksessa selvitettiin, mika näista hajoamistuotteista sopisi parhaiten rasituksen voimakkuuden mittaamiseen hevosella. Tutkimuksessa määritetään lämminveristen ravihevosten plasmasta ATP:n pilkkoutuessa syntyvien puriinien (hypoksantiini ja virtsahappo) sekä niiden lopullisen hajoamistuotteen allantoiinin konsentraatioita rasituksen aikana ja sen jälkeen. Lihassyykoostumuksen vaikutusta hypoksantiinin, virtsahapon ja allantoiinin konsentraatioihin tutkittiin vertailemalla suomenhevosia ja lämminverisiä kaskenaan. Tiedetään, että kylmäverisellä hevosella on enemmän hitaita aerobisesti energiansa muodostavia lihassoluja kuin lämminverisellä. Kontrolloidussa rasitustestissä juoksumatolla hypoksantiini- ja virtsahappokonsentraatiot eivät muuttuneet merkitsevästi. Kaikilla hevosilla korkeimmat konsentraatiot saavutettiin rasituksen lopettamisen jälkeen. Allantoiinikonsentraation nousu korreloi lineaarisesti sydänfrekvenssin nousuun ja oli merkittävästi korkeampi rasituksen jälkeen kuin leponäytteissä. Yksilöllinen vaihtelu ajassa, jossa korkein konsentraatio saavutettiin, oli pienempi allantoiinilla kuin hypoksantiinilla tai virtsahapolla. Ravikilpailujen jälkeen otetuissa näytteissä hypoksantiini-, virtsahappo- ja allantoiini- konsentraatiot olivat merkittävästi korkeampia lämminverisillä kuin suomenhevosilla. Rotujen väliset erot konsentraatioissa johtuvat todennäköisesti erilaisesta lihassyykoostumuksesta. Hypoksantiini- ja virtsahappokonsentraatio nousi osalla hevosista molemmilla roduilla vielä 30 minuuttia kilpailun jälkeen. Allantoiinikonsentraatio ei yhdellakään hevosella ollut 30 minuutin näytteessä korkeampi kuin 15 minuutin näytteessä. Sekä hypoksantiinilla, virtsahapolla seka mahdollisesti myös allantoiinilla rasituksen voimakkuus vaikutti konsentraatiohuipun esiintymisaikaan, joka piteni rasituksen koventuessa. Tulosten perusteella allantoiini sopii hypoksantiinia ja virtsahappoa paremmin rasituksen voimakkuuden ja ATP hävion osoittamiseen hevosella.
  • Pakarinen, Sami (Helsingin yliopisto, 2013)
    Dual chamber pacing can be employed to restore atrioventricular synchrony in patients with heart block; and chronotropic incompetence and sinus bradycardia in those with sinus node dysfunction (SND). The focus of this thesis is the feasibility and consequences of proper atrial sensing and pacing to atrioventricular (AV) synchrony in dual chamber pacing. With isolated AV block showed that single lead VDD pacing (single pass ventricular lead with a dual chamber electrode system) can be an alternative to standard dual chamber pacing systems. Adequate sinus-driven atrial rate and no history of paroxysmal atrial fibrillation or cardiac enlargement predict reasonably good long-term maintenance of the VDD pacing mode in elderly patients treated for heart block. Retrograde atrial waves can be discriminated from sinus waves in many patients by using a high sampling rate and algorithms for digital signal processing with data collected by a pacemaker (PM). This approach could enhance the capability of future devices to adapt their stimulation to the spontaneous heart rhythm and improve the collection of diagnostic information on arrhythmias. Atrial tachyarrhythmia (AT) sensing algorithms incorporated in a state-of-the art DDDR (dual lead atrioventricular pacing) pacemaker can accurately identify patients who develop ATs. However transient undersensing of continuous atrial fibrillation (AF) and failure to detect very short episodes ATs can occur frequently, despite the use of refined detection algorithms. With a fixed long AV delay in DDDR pacing as in this study, temporal disruption of AV synchrony and inappropriate mode switch (MS) due to repetitive non-reentrant ventriculo-atrial synchronous rhythm (RNRVAS) is relatively common with SND patients (in 25%) in the presence of retrograde VA conduction. An advanced atrio ventricular search hysteresis (AVSH) algorithm reduced incidence of unnecessary ventricular pacing in the majority of SND patients with both intact and impaired AV conduction and in patients with intermittent AV block, regardless of the lead positions in the right atrium and the ventricle. The avoidance of possible harmful right ventricular (RV) pacing with used state of art AVSH algorithm was not associated with unphysiological over-long AV delays. In conclusion, proper atrial detection and timing for atrioventricular pacing is also feasible in the long-term with contemporary clinical pacing. With appropriate programming, these devices may contribute to the avoidance of possible adverse consequences like congestive heart failure, atrial fibrillation and unwanted harmful symptoms. In future devices with digital signal processing the detection of atrial signals can be further improved.
  • Jurkko, Raija (Helsingin yliopisto, 2009)
    Atrial fibrillation (AF) is the most common tachyarrhythmia and is associated with substantial morbidity, increased mortality and cost. The treatment modalities of AF have increased, but results are still far from optimal. More individualized therapy may be beneficial. Aiming for this calls improved diagnostics. Aim of this study was to find non-invasive parameters obtained during sinus rhythm reflecting electrophysiological patterns related to propensity to AF and particularly to AF occurring without any associated heart disease, lone AF. Overall 240 subjects were enrolled, 136 patients with paroxysmal lone AF and 104 controls (mean age 45 years, 75% males). Signal measurements were performed by non-invasive magnetocardiography (MCG) and by invasive electroanatomic mapping (EAM). High-pass filtering techniques and a new method based on a surface gradient technique were adapted to analyze atrial MCG signal. The EAM was used to elucidate atrial activation in patients and as a reference for MCG. The results showed that MCG mapping is an accurate method to detect atrial electrophysiologic properties. In lone paroxysmal AF, duration of the atrial depolarization complex was marginally prolonged. The difference was more obvious in women and was also related to interatrial conduction patterns. In the focal type of AF (75%), the root mean square (RMS) amplitudes of the atrial signal were normal, but in AF without demonstrable triggers the late atrial RMS amplitudes were reduced. In addition, the atrial characteristics tended to remain similar even when examined several years after the first AF episodes. The intra-atrial recordings confirmed the occurrence of three distinct sites of electrical connection from right to left atrium (LA): the Bachmann bundle (BB), the margin of the fossa ovalis (FO), and the coronary sinus ostial area (CS). The propagation of atrial signal could also be evaluated non-invasively. Three MCG atrial wave types were identified, each of which represented a distinct interatrial activation pattern. In conclusion, in paroxysmal lone AF, active focal triggers are common, atrial depolarization is slightly prolonged, but with a normal amplitude, and the arrhythmia does not necessarily lead to electrical or mechanical dysfunction of the atria. In women the prolongation of atrial depolarization is more obvious. This may be related to gender differences in presentation of AF. A significant minority of patients with lone AF lack frequent focal triggers, and in them, the late atrial signal amplitude is reduced, possibly signifying a wider degenerative process in the LA. In lone AF, natural impulse propagation to LA during sinus rhythm goes through one or more of the principal pathways described. The BB is the most common route, but in one-third, the earliest LA activation occurs outside the BB. Susceptibility to paroxysmal lone AF is associated with propagation of the atrial signal via the margin of the FO or via multiple pathways. When conduction occurs via the BB, it is related with prolonged atrial activation. Thus, altered and alternative conduction pathways may contribute to pathogenesis of lone AF. There is growing evidence of variability in genesis of AF also within lone paroxysmal AF. Present study suggests that this variation may be reflected in cardiac signal pattern. Recognizing the distinct signal profiles may assist in understanding the pathogenesis of AF and identifying subgroups for patient-tailored therapy.
  • Lehto, Mika (Helsingin yliopisto, 2009)
    Atrial fibrillation is the most common arrhythmia requiring treatment. This Thesis investigated atrial fibrillation (AF) with a specific emphasis on atrial remodeling which was analysed from epidemiological, clinical and magnetocardiographic (MCG) perspectives. In the first study we evaluated in real-life clinical practice a population-based cohort of AF patients referred for their first elective cardioversion (CV). 183 consecutive patients were included of whom in 153 (84%) sinus rhythm (SR) was restored. Only 39 (25%) of those maintained SR for one year. Shorter duration of AF and the use of sotalol were the only characteristics associated with better restoration and maintenance of SR. During the one-year follow-up 40% of the patients ended up in permanent AF. Female gender and older age were associated with the acceptance of permanent AF. The LIFE-trial was a prospective, randomised, double-blinded study that evaluated losartan and atenolol in patients with hypertension and left ventricular hypertrophy (LVH). Of the 8,851 patients with SR at baseline and without a history of AF 371 patients developed new-onset AF during the study. Patients with new-onset AF had an increased risk of cardiac events, stroke, and increased rate of hospitalisation for heart failure. Younger age, female gender, lower systolic blood pressure, lesser LVH in ECG and randomisation to losartan therapy were independently associated with lower frequency of new-onset AF. The impact of AF on morbidity and mortality was evaluated in a post-hoc analysis of the OPTIMAAL trial that compared losartan with captopril in patients with acute myocardial infarction (AMI) and evidence of LV dysfunction. Of the 5,477 randomised patients 655 had AF at baseline, and 345 patients developed new AF during the follow-up period, median 3.0 years. Older patients and patients with signs of more serious heart disease had and developed AF more often. Patients with AF at baseline had an increased risk of mortality (hazard ratio (HR) of 1.32) and stroke (HR 1.77). New-onset AF was associated with increased mortality (HR 1.82) and stroke (HR of 2.29). In the fourth study we assessed the reproducibility of our MCG method. This method was used in the fifth study where 26 patients with persistent AF had immediately after the CV longer P-wave duration and higher energy of the last portion of atrial signal (RMS40) in MCG, increased P-wave dispersion in SAECG and decreased pump function of the atria as well as enlarged atrial diameter in echocardiography compared to age- and disease-matched controls. After one month in SR, P-wave duration in MCG still remained longer and left atrial (LA) diameter greater compared to the controls, while the other measurements had returned to the same level as in the control group. In conclusion is not a rare condition in either general population or patients with hypertension or AMI, and it is associated with increased risk of morbidity and mortality. Therefore, atrial remodeling that increases the likelihood of AF and also seems to be relatively stable has to be identified and prevented. MCG was found to be an encouraging new method to study electrical atrial remodeling and reverse remodeling. RAAS-suppressing medications appear to be the most promising method to prevent atrial remodeling and AF.
  • Lagerblom, Kalle (2013)
    Tämän Pro gradu –tutkielman kirjallisuuskatsaus käsittelee atsa-Michael-reaktiota, joka on typpinukleofiilin additioreaktio elektroniköyhään kaksoissidokseen. Reaktio on tyypiltään konjugaattiadditio, eli elektrofiilinä toimiva alkeeni on konjugoitunut elektroneja puoleensa vetävään ryhmään kuten karbonyyliin tai nitriiliin. Atsa-Michael-reaktiota käytetään usein synteeseissä, jotka tähtäävät β-aminoituihin karbonyyleihin, alkoholeihin tai aldehydeihin ja reaktio on tällä saralla hyvin merkittävä, sillä se on Mannich-reaktion ohella yleinen tapa tuottaa edellä mainittuja yhdisteitä. Tutkielmassa käsitellään esimerkein reaktion teoriaa ja yleisimmin käytettyjä katalyyttejä. Tutkielman kokeellinen osuus käisttelee selluloosa-akrylaatin synteesiä ja tähän templaattiin suoritettuja atsa-Michael- ja Diels-Alder-reaktioita. Sekä selluloosa-akrylaatin synteesi että jatkoreaktiot tähän templaattiin onnistuivat hyvin.
  • Pontán, Anne-Marie (2008)
    Ett viktigt mål inom äldrepolitiken som social- och hälsovårdsministeriet har satt upp har varit att satsa på att främja de äldres välbefinnande, deras rätt till ett självständigt liv och egen aktivitet. De äldre ska kunna bo tryggt hemma så länge det är möjligt. Närståendevården anses vara ett viktigt alternativ för den växande skara äldre samtidigt som den offentliga servicen minskar. År 2012 ska 91-92 procent av den äldrebefolkningen bo kvar hemma och 5-6 procent av över 75 år fyllda ska få stöd för närståendevård. Man uppskattar att 300 000 närståendevårdare tar hand om en anhörig och av dessa är över 26 000 inom kommunal närståendevård. Mitt intresse för närståendevården tar sin utgångspunkt till min nuvarande arbetsplats och jag har valt att forska i min egen arbetsgemenskap, svensk socialservice, enheten för äldreomsorg. Socialarbetarna och socialhandledarna har tidigare prövat på pararbete att med hjälp av med förebyggande socialt arbete kunna göra interventioner för att stöda familjerna. Men hur formar sig pararbetet och vilka element består det av? Vad innebär processen? Forskningsproblemet har stigit fram ur det praktiska arbetet och jag utför aktionsforskning som en samverkande undersökning. Den främsta metoden är fokusgruppsdiskussioner. Man kan använda aktionsforskning till att utveckla det egna arbetet och den egna arbetsgemenskapen. Studien visar att fokusgruppsdiskussionerna gav en större förståelse för pararbetet. Att bli närståendevårdare är en process som tar lång tid. Att öppna dörren för myndigheter är för många närståendevårdarfamiljer en ny situation. I fokusgruppsdiskussionerna steg nya kritiska element upp. Var går gränsen för den etiska och moraliska aspekten då den ena i ett äldre par inte orkar vårda den andra? I närståendevårdarfamiljerna kan uppstå svåra situationer när t.ex. klienten har en svår demenssjukdom eller då det är fråga om vanskötsel av klienten. Deltagarna diskuterade de diffusa rollerna i pararbetet. Speciellt socialarbetarens diffusa roll lyftes upp. En medvetenhet om ett tydligt behov av att utveckla arbetssätten och arbetsmetoderna inom gruppen uppstod. De centrala källorna för min studie är Saarenheimo & Pietilä (2005), Vilkko, Anni (2005, 2006), Lymbery, Mark (2007) och Salonen (2001).