Forebrain-independent generation of hyperthermic convulsions in infant rats

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http://hdl.handle.net/10138/177886

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Pospelov , A S , Yukin , A Y , Blumberg , M S , Puskarjov , M & Kaila , K 2016 , ' Forebrain-independent generation of hyperthermic convulsions in infant rats ' , Epilepsia , vol. 57 , no. 1 , pp. E1-E6 . https://doi.org/10.1111/epi.13230

Title: Forebrain-independent generation of hyperthermic convulsions in infant rats
Author: Pospelov, Alexey S.; Yukin, Alexey Y.; Blumberg, Mark S.; Puskarjov, Martin; Kaila, Kai
Contributor: University of Helsinki, Biosciences
University of Helsinki, Biosciences
University of Helsinki, Biosciences
University of Helsinki, Biosciences
Date: 2016-01
Language: eng
Number of pages: 6
Belongs to series: Epilepsia
ISSN: 0013-9580
URI: http://hdl.handle.net/10138/177886
Abstract: Febrile seizures are the most common type of convulsive events in children. It is generally assumed that the generalization of these seizures is a result of brainstem invasion by the initial limbic seizure activity. Using precollicular transection in 13-day-old rats to isolate the forebrain from the brainstem, we demonstrate that the forebrain is not required for generation of tonic-clonic convulsions induced by hyperthermia or kainate. Compared with sham-operated littermate controls, latency to onset of convulsions in both models was significantly shorter in pups that had undergone precollicular transection, indicating suppression of the brainstem seizure network by the forebrain in the intact animal. We have shown previously that febrile seizures are precipitated by hyperthermia-induced respiratory alkalosis. Here, we show that triggering of hyperthermia-induced hyperventilation and consequent convulsions in transected animals are blocked by diazepam. The present data suggest that the role of endogenous brainstem activity in triggering tonic-clonic seizures should be re-evaluated in standard experimental models of limbic seizures. Our work sheds new light on the mechanisms that generate febrile seizures in children and, therefore, on how they might be treated.
Subject: Brainstem
Precollicular transection
Febrile seizures
Diazepam
Kainic acid
EXPERIMENTAL FEBRILE SEIZURES
BRAIN-STEM
RESPIRATORY ALKALOSIS
ACTIVATION
CHILDREN
SLEEP
3112 Neurosciences
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