Forebrain-independent generation of hyperthermic convulsions in infant rats

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dc.contributor.author Pospelov, Alexey S.
dc.contributor.author Yukin, Alexey Y.
dc.contributor.author Blumberg, Mark S.
dc.contributor.author Puskarjov, Martin
dc.contributor.author Kaila, Kai
dc.date.accessioned 2017-03-20T11:05:01Z
dc.date.available 2017-03-20T11:05:01Z
dc.date.issued 2016-01
dc.identifier.citation Pospelov , A S , Yukin , A Y , Blumberg , M S , Puskarjov , M & Kaila , K 2016 , ' Forebrain-independent generation of hyperthermic convulsions in infant rats ' , Epilepsia , vol. 57 , no. 1 , pp. E1-E6 . https://doi.org/10.1111/epi.13230
dc.identifier.other PURE: 62170530
dc.identifier.other PURE UUID: 121c1f41-0989-446a-a101-324c4a7405e5
dc.identifier.other WOS: 000368132100001
dc.identifier.other Scopus: 84954056007
dc.identifier.other ORCID: /0000-0003-0668-5955/work/29319259
dc.identifier.uri http://hdl.handle.net/10138/177886
dc.description.abstract Febrile seizures are the most common type of convulsive events in children. It is generally assumed that the generalization of these seizures is a result of brainstem invasion by the initial limbic seizure activity. Using precollicular transection in 13-day-old rats to isolate the forebrain from the brainstem, we demonstrate that the forebrain is not required for generation of tonic-clonic convulsions induced by hyperthermia or kainate. Compared with sham-operated littermate controls, latency to onset of convulsions in both models was significantly shorter in pups that had undergone precollicular transection, indicating suppression of the brainstem seizure network by the forebrain in the intact animal. We have shown previously that febrile seizures are precipitated by hyperthermia-induced respiratory alkalosis. Here, we show that triggering of hyperthermia-induced hyperventilation and consequent convulsions in transected animals are blocked by diazepam. The present data suggest that the role of endogenous brainstem activity in triggering tonic-clonic seizures should be re-evaluated in standard experimental models of limbic seizures. Our work sheds new light on the mechanisms that generate febrile seizures in children and, therefore, on how they might be treated. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Epilepsia
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Brainstem
dc.subject Precollicular transection
dc.subject Febrile seizures
dc.subject Diazepam
dc.subject Kainic acid
dc.subject EXPERIMENTAL FEBRILE SEIZURES
dc.subject BRAIN-STEM
dc.subject RESPIRATORY ALKALOSIS
dc.subject ACTIVATION
dc.subject CHILDREN
dc.subject SLEEP
dc.subject 3112 Neurosciences
dc.title Forebrain-independent generation of hyperthermic convulsions in infant rats en
dc.type Article
dc.contributor.organization Biosciences
dc.contributor.organization Kai Kaila / Principal Investigator
dc.contributor.organization Neuroscience Center
dc.contributor.organization Laboratory of Neurobiology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1111/epi.13230
dc.relation.issn 0013-9580
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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