Intestinal microbiome landscaping : insight in community assemblage and implications for microbial modulation strategies

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dc.contributor.author Shetty, Sudarshan A.
dc.contributor.author Hugenholtz, Floor
dc.contributor.author Lahti, Leo
dc.contributor.author Smidt, Hauke
dc.contributor.author de Vos, Willem M.
dc.date.accessioned 2017-03-24T13:04:01Z
dc.date.available 2017-03-24T13:04:01Z
dc.date.issued 2017-03
dc.identifier.citation Shetty , S A , Hugenholtz , F , Lahti , L , Smidt , H & de Vos , W M 2017 , ' Intestinal microbiome landscaping : insight in community assemblage and implications for microbial modulation strategies ' , FEMS Microbiology Reviews , vol. 41 , no. 2 , pp. 182-199 . https://doi.org/10.1093/femsre/fuw045
dc.identifier.other PURE: 81961158
dc.identifier.other PURE UUID: b3b2065f-41d5-4a1b-9fe6-2e310b8a0f64
dc.identifier.other WOS: 000396366700005
dc.identifier.other Scopus: 85016188292
dc.identifier.uri http://hdl.handle.net/10138/178243
dc.description.abstract High individuality, large complexity and limited understanding of the mechanisms underlying human intestinal microbiome function remain the major challenges for designing beneficial modulation strategies. Exemplified by the analysis of intestinal bacteria in a thousand Western adults, we discuss key concepts of the human intestinal microbiome landscape, i.e. the compositional and functional 'core', the presence of community types and the existence of alternative stable states. Genomic investigation of core taxa revealed functional redundancy, which is expected to stabilize the ecosystem, as well as taxa with specialized functions that have the potential to shape the microbiome landscape. The contrast between Prevotella-and Bacteroides-dominated systems has been well described. However, less known is the effect of not so abundant bacteria, for example, Dialister spp. that have been proposed to exhibit distinct bistable dynamics. Studies employing time-series analysis have highlighted the dynamical variation in the microbiome landscape with and without the effect of defined perturbations, such as the use of antibiotics or dietary changes. We incorporate ecosystem-level observations of the human intestinal microbiota and its keystone species to suggest avenues for designing microbiome modulation strategies to improve host health. en
dc.format.extent 18
dc.language.iso eng
dc.relation.ispartof FEMS Microbiology Reviews
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject alternative stable states
dc.subject bistability
dc.subject core microbiota
dc.subject early warning signals
dc.subject landscape model
dc.subject tipping elements
dc.subject HUMAN GUT MICROBIOME
dc.subject INFLAMMATORY-BOWEL-DISEASE
dc.subject PHYLOGENETIC MICROARRAY
dc.subject FECAL MICROBIOTA
dc.subject AKKERMANSIA-MUCINIPHILA
dc.subject GASTROINTESTINAL-TRACT
dc.subject ULCERATIVE-COLITIS
dc.subject IN-VITRO
dc.subject BACTERIA
dc.subject DIVERSITY
dc.subject 1183 Plant biology, microbiology, virology
dc.subject 3111 Biomedicine
dc.title Intestinal microbiome landscaping : insight in community assemblage and implications for microbial modulation strategies en
dc.type Review Article
dc.contributor.organization Medicum
dc.contributor.organization Willem Meindert Vos de / Principal Investigator
dc.contributor.organization Immunobiology Research Program
dc.contributor.organization Research Programs Unit
dc.contributor.organization Department of Bacteriology and Immunology
dc.contributor.organization de Vos & Salonen group
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/femsre/fuw045
dc.relation.issn 0168-6445
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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