GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function : a report from the COGENT consortium

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Trampush , J W , Yang , M L Z , Yu , J , Knowles , E , Davies , G , Liewald , D C , Starr , J M , Djurovic , S , Melle , I , Sundet , K , Christoforou , A , Reinvang , I , DeRosse , P , Lundervold , A J , Steen , V M , Espeseth , T , Räikkönen , K , Widen , E , Palotie , A , Eriksson , J G , Giegling , I , Konte , B , Roussos , P , Giakoumaki , S , Burdick , K E , Payton , A , Ollier , W , Horan , M , Chiba-Falek , O , Attix , D K , Need , A C , Cirulli , E T , Voineskos , A N , Stefanis , N C , Avramopoulos , D , Hatzimanolis , A , Arking , D E , Smyrnis , N , Bilder , R M , Freimer , N A , Cannon , T D , London , E , Poldrack , R A , Sabb , F W , Congdon , E , Conley , E D , Scult , M A , Dickinson , D , Straub , R E , Donohoe , G , Morris , D , Corvin , A , Gill , M , Hariri , A R , Weinberger , D R , Pendleton , N , Bitsios , P , Rujescu , D , Lahti , J , Le Hellard , S , Keller , M C , Andreassen , O A , Deary , I J , Glahn , D C , Malhotra , A K & Lencz , T 2017 , ' GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function : a report from the COGENT consortium ' , Molecular Psychiatry , vol. 22 , no. 3 , pp. 336-345 . https://doi.org/10.1038/mp.2016.244

Title: GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function : a report from the COGENT consortium
Author: Trampush, J. W.; Yang, M. L. Z.; Yu, J.; Knowles, E.; Davies, G.; Liewald, D. C.; Starr, J. M.; Djurovic, S.; Melle, I.; Sundet, K.; Christoforou, A.; Reinvang, I.; DeRosse, P.; Lundervold, A. J.; Steen, V. M.; Espeseth, T.; Räikkönen, Katri; Widen, E.; Palotie, A.; Eriksson, J. G.; Giegling, I.; Konte, B.; Roussos, P.; Giakoumaki, S.; Burdick, K. E.; Payton, A.; Ollier, W.; Horan, M.; Chiba-Falek, O.; Attix, D. K.; Need, A. C.; Cirulli, E. T.; Voineskos, A. N.; Stefanis, N. C.; Avramopoulos, D.; Hatzimanolis, A.; Arking, D. E.; Smyrnis, N.; Bilder, R. M.; Freimer, N. A.; Cannon, T. D.; London, E.; Poldrack, R. A.; Sabb, F. W.; Congdon, E.; Conley, E. D.; Scult, M. A.; Dickinson, D.; Straub, R. E.; Donohoe, G.; Morris, D.; Corvin, A.; Gill, M.; Hariri, A. R.; Weinberger, D. R.; Pendleton, N.; Bitsios, P.; Rujescu, D.; Lahti, J.; Le Hellard, S.; Keller, M. C.; Andreassen, O. A.; Deary, I. J.; Glahn, D. C.; Malhotra, A. K.; Lencz, T.
Contributor: University of Helsinki, Medicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Helsinki Collegium for Advanced Studies
Date: 2017-03
Language: eng
Number of pages: 10
Belongs to series: Molecular Psychiatry
ISSN: 1359-4184
URI: http://hdl.handle.net/10138/178657
Abstract: The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P
Subject: GENOME-WIDE ASSOCIATION
SCOTTISH MENTAL SURVEY
UK BIOBANK N=112151
EDUCATIONAL-ATTAINMENT
INTELLECTUAL DISABILITY
DEVELOPMENTAL DELAY
EXECUTIVE FUNCTION
HUMAN INTELLIGENCE
PROVIDES INSIGHTS
ABILITY
3124 Neurology and psychiatry
1182 Biochemistry, cell and molecular biology
515 Psychology
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