Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers

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http://hdl.handle.net/10138/179242

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Sulkava , S , Ollila , H M , Alasaari , J , Puttonen , S , Harma , M , Viitasalo , K , Lahtinen , A , Lindstrom , J , Toivola , A , Sulkava , R , Kivimaki , M , Vahtera , J , Partonen , T , Silander , K , Porkka-Heiskanen , T & Paunio , T 2017 , ' Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers ' , Sleep , vol. 40 , no. 1 , 011 . https://doi.org/10.1093/sleep/zsw011

Title: Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers
Author: Sulkava, Sonja; Ollila, Hanna M.; Alasaari, Jukka; Puttonen, Sampsa; Harma, Mikko; Viitasalo, Katriina; Lahtinen, Alexandra; Lindstrom, Jaana; Toivola, Auli; Sulkava, Raimo; Kivimaki, Mika; Vahtera, Jussi; Partonen, Timo; Silander, Kaisa; Porkka-Heiskanen, Tarja; Paunio, Tiina
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, Finnish Institute of Occupational Health (TTL)
University of Helsinki, Medicum
University of Helsinki, University of Helsinki
Date: 2017-01-01
Language: eng
Number of pages: 10
Belongs to series: Sleep
ISSN: 0161-8105
URI: http://hdl.handle.net/10138/179242
Abstract: Study Objectives: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift work. Methods: We assessed intolerance to shift work with job-related exhaustion symptoms in shift workers using the emotional exhaustion subscale of the Maslach Burnout Inventory-General Survey, and carried out a genome-wide association study (GWAS) using Illumina's Human610-Quad BeadChip (n = 176). The most significant findings were further studied in three groups of Finnish shift workers (n = 577). We assessed methylation in blood cells with the Illumina HumanMethylation450K BeadChip, and examined gene expression levels in the publicly available eGWAS Mayo data. Results: The second strongest signal identified in the GWAS (p = 2.3 x 10E-6) was replicated in two of the replication studies with p Conclusions: These findings suggest that a variant near MTNR1A may be associated with job-related exhaustion in shift workers. The risk variant may exert its effect via epigenetic mechanisms, potentially leading to reduced melatonin signaling in the brain. These results could indicate a link between melatonin signaling, a key circadian regulatory mechanism, and tolerance to shift work.
Subject: genome-wide association study
job-related exhaustion
shift work
MTNR1A
DNA methylation
GENOME-WIDE ASSOCIATION
INDIVIDUAL-DIFFERENCES
INTERNAL DESYNCHRONIZATION
CIRCADIAN-RHYTHMS
NIGHT WORKERS
HUMAN BRAIN
METAANALYSIS
BURNOUT
SLEEP
METHYLATION
3112 Neurosciences
3124 Neurology and psychiatry
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