Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use

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Korpela , K , Zijlmans , M A C , Kuitunen , M , Kukkonen , K , Savilahti , E , Salonen , A , de Weerth , C & de Vos , W M 2017 , ' Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use ' , Microbiome , vol. 5 , 26 . https://doi.org/10.1186/s40168-017-0245-y

Title: Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use
Author: Korpela, K.; Zijlmans, M. A. C.; Kuitunen, M.; Kukkonen, K.; Savilahti, E.; Salonen, Anne; de Weerth, C.; de Vos, W. M.
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Clinicum
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Children's Hospital
University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2017-03-03
Language: eng
Number of pages: 9
Belongs to series: Microbiome
ISSN: 2049-2618
URI: http://hdl.handle.net/10138/180175
Abstract: Background: Children with high body mass index (BMI) at preschool age are at risk of developing obesity. Early identification of factors that increase the risk of excessive weight gain could help direct preventive actions. The intestinal microbiota and antibiotic use have been identified as potential modulators of early metabolic programming and weight development. To test if the early microbiota composition is associated with later BMI, and if antibiotic use modifies this association, we analysed the faecal microbiota composition at 3 months and the BMI at 5-6 years in two cohorts of healthy children born vaginally at term in the Netherlands (N = 87) and Finland (N = 75). We obtained lifetime antibiotic use records and measured weight and height of all children. Results: The relative abundance of streptococci was positively and the relative abundance of bifidobacteria negatively associated with the BMI outcome. The association was especially strong among children with a history of antibiotic use. Bacteroides relative abundance was associated with BMI only in the children with minimal lifetime antibiotic exposure. Conclusions: The intestinal microbiota of infants are predictive of later BMI and may serve as an early indicator of obesity risk. Bifidobacteria and streptococci, which are indicators of microbiota maturation in infants, are likely candidates for metabolic programming of infants, and their influence on BMI appears to depend on later a\ntibiotic use.
Subject: Early
life microbiota
Childhood overweight
Bifidobacteria
Metabolic programming
Microarray
HIGH-FAT-DIET
INTESTINAL MICROBIOTA
GUT MICROBIOTA
INSULIN-RESISTANCE
METABOLIC DISEASE
INDUCED OBESITY
BODY-MASS
OVERWEIGHT
CHILDREN
WEIGHT
1183 Plant biology, microbiology, virology
3111 Biomedicine
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