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  • Itkonen, Juha (Bank of Finland, 2015)
    Climate change is one of the greatest market failures of our time. This thesis consists of three essays in which we study the economics of climate change using networks as a theoretical framework. In the first essay, we discover flaws in the foundations of a recent strand of literature estimating the carbon Kuznets curve (CKC). The CKC hypothesizes that carbon dioxide emissions initially increase with economic growth but that the relationship is eventually reversed. The recent literature attempts to estimate the CKC by adding energy consumption as a control variable. Due to model misspecifications related to the econometric methodology and database definitions, the results are biased to support the existence of a CKC. Consequently, the literature underestimates the need for climate policies. In the second essay, we study how social networks might help to explain why differences of opinion about climate change persist across segments of the lay public despite the scientific consensus. To do this, we programmed a Facebook application that collected survey data on concerns about climate change and network data on friendships. We found that respondents tend to have friends with similar concerns as their own, the unconcerned respondents have fewer friends, and any two respondents who disagreed about the seriousness of global warming were less than half as likely to be friends. The results indicate that the structure of the social network may hinder changes in opinions, explaining why opinions persist despite the scientific consensus. The results suggest that the communication of climate science could be improved by strategies that aim to overcome these network effects. In the third essay, we study permit markets which are connected by a network of links. A link allows participants of one emissions trading system to use permits of other systems. In a linked network of markets, foreign regulators can influence domestic policy outcomes even without a direct link. We apply graph theory to study these dependencies between markets to determine who exactly can affect domestic emissions and prices. We characterize the equilibrium's dependency structure assuming perfect competition and an exogenous trading network. The results help to avoid unexpected foreign interference with domestic policy outcomes and to secure the effectiveness of climate change policies.
  • Andersen, Claus Elholm (University of Helsinki, 2015)
    You have to be on your guard On Literariness in Karl Ove Knausgård s My Struggle This dissertation is a discussion of literariness in Karl Ove Knausgård s novel My Struggle (2009-2011). I argue that My Struggle first and foremost is a novel and should be read accordingly. Though Knausgård might challenge the genre of the novel as we know it, I show how he does so within the framework of one of the strongest traditions in the 20th century. This tradition includes writers such as Proust, Joyce, and Thomas Mann, all of whom, like Knausgård, have sought to challenge the novel as such. Thus, Knausgård is stretching the limits of what a novel can be by taking his point of departure in the challenge that already exists in the genre. Read this way, Knausgård expands the limits of what a novel is and can do, so it becomes impossible to ignore him as a novelist. The dissertation is based on five articles published, or accepted for publication, in peer-reviewed academic journals. Combined, these articles show how Knausgård as a writer belongs to a literary tradition that can be seen as an extension of literary modernism. In each article, I identify what I have named the central paradox of the novel that Knausgård wants to write honestly about his life, but can only do so in the form of a novel and by using the literary devices from the world of fiction. It is through the analysis of this central paradox that I portray the literariness of the novel. Aside from the five articles, the dissertation also consists of a cap or a summarizing report where I place the articles in relation to the existing scholarship on Knausgård and explain my theoretical framework and why I consider it important to read My Struggle as novel. Here, I argue that the dissertation is in clear opposition to the majority of what has previously been written on Knausgård, where the focus has been on how Knausgård plays with reality and fiction instead of striving to understand what the novel is trying to say.
  • Konttori, Johanna (2015)
    The aim of this study is to add a new perspective to the large body of scholarly work dealing with the debates on the use of headscarves and full veils in contemporary France. The study examines the discursive construction of national identity by members of the political and social elite as they discuss the use of headscarves in state schools, and the use of full veils in the public sphere more generally. The new perspective that the study presents is threefold. First, the study examines both headscarf and full veil debates, which have so far been mainly studied separately. Second, the data consists of the little-studied transcripts of the hearings organized by the two parliamentary commissions (the Debré and Gerin Commissions) that looked into the headscarf and full veil issues in 2003 and 2009, respectively. Third, even though it has been widely noted in the existing research literature that the headscarf and full veil debates were linked to national identity, it has not been common to draw theoretical insights from nationalism studies, as is done here. The analytical focus is on Muslims and Islam, headscarves and full veils, and their relation to the Republic, its identity and values (notably laïcité). Using analytical tools derived from the discourse-historical approach, the study shows the great variety of different perceptions of Islam and Muslims, but also laïcité, in the data. Even though headscarves and especially full veils are mostly regarded as problematic and even threatening to the Republic, this does not necessarily result in negative perceptions of Muslims and Islam. Finally, the study ponders the usefulness of binary categories. It is concluded that neither the Us vs Them categorization often linked to the construction of national identities nor the claim of Muslims as Others in France entirely fit the data. Instead, it is suggested that the concepts of stranger and national capital enable a more nuanced examination of the place of Muslims and Islam in France.
  • Mönttinen, Heli (2015)
    The right-hand-shaped polymerases comprising the DNA/RNA polymerase superfamily represent at least six different protein families containing replicases, transcriptases and repair proteins from all three domains of life as well as from their viruses. All of these polymerases have at least three subdomains: fingers, palm and thumb, which form together a structure resembling a right-hand. The catalytic site is located in the palm subdomain, in which polymerization process is catalysed by two Mg2+ ions. There can also be additional ions such as the non-catalytic ion in the RNA-dependent RNA polymerase of phage φ6, which is located approximately 6 Ångströms from the catalytic site. The phylogeny and common regions of the right-hand-shaped polymerases have been previously studied mainly using amino acid sequence alignments. However, the sequence similarity between polymerases belonging into different protein families is low and therefore, the structure alignment provides a potential alternative because protein structures can retain similarity longer in evolution than amino acid sequences. In this thesis, the common structural features between and within the families of the right-hand-shaped polymerases are described, and based on the structural cores the phylogenetic trees are deduced. In addition, the phylogenetic relationships between the right-hand-shaped polymerases and other structurally related proteins are described. As results, it is shown that a phylogenetic tree following the established boundaries of protein families is possible to construct based on structural core sharing no sequence identity. This tree, illustrating long distance phylogenetic relationships suggests that the known right-hand-shaped polymerase families are not the closest relatives to each other. The phylogenies within polymerase families suggest that the relationships among the polymerases do not always follow the evolution of the corresponding organism, which implies horizontal gene transfer between cells, and cells and viruses. The phylogeny of RNA virus RNA polymerases seem to be dependent on the priming mechanism and it does not follow the virion architecture or the Baltimore classification. In addition, the viral RNA-dependent RNA polymerases seem to share a third ion binding site in the proximity of catalytic site.
  • Lindh, Erika (Hansaprint, 2015)
    Influenza A virus (IAV) is a significant zoonotic pathogen, with a diverse range of subtypes infecting both humans and birds. NDV is the causative agent of Newcastle Disease, a significant infectious disease of poultry. While wild waterfowl, the natural host, remains apparently healthy during the even frequent infections with these viruses, poultry is susceptible for mild to severe disease. Both viruses have a heavy impact on the poultry industry by causing outbreaks with significant economical losses. Low pathogenic IAV and NDV viruses are efficiently transmitted in host populations and have the ability to mutate and become virulent. The segmented genome of IAV also allows it to reassort during dual infections, giving rise to novel viruses with unpredictable pathogenic properties including the potential to transmit to humans and other mammals. Extensive surveillance studies of IAV and NDV during the past decades have revealed their wide global distribution and host species range. Previous surveillance studies have yielded limited information about avian IAV in Finland and so far, NDV has been the causative agent of varying outbreaks in Finland, for example in poultry, a zoo and domestic pigeons. This project was initiated for surveillance purposes, to gather information about prevalence and subtype/genotype distribution of IAVs and NDVs and to assess the potential presence of highly pathogenic strains in wild waterfowl in Finland. Through annual sampling and screening of wild waterfowl, 875 birds were screened during the years 2006-2010 and 2014. The birds represent mainly young, hunted ducks from local breeding areas. We detected altogether 76 IAVs (in 8.7%) and 39 NDVs (in 5.5%). From most of the samples (75%) the viruses were successfully propagated in embryonated chicken eggs and partially sequenced for phylogenetic and pathogenicity analyses. Importantly, while no highly pathogenic strains were encountered, several of the wild waterfowl derived viruses detected in Finland were phylogenetically closely related to viruses detected during outbreaks in Finland and elsewhere in Europe. These viruses includ IAV subtypes H5N2, H7N3, H9N2 as well as NDVs. An unexpectedly high subtype dominance of H3N8 was recorded each year, counting for over 60% of all the subtyped IAVs. Genetic characterization of these viruses demonstrated high sequence homology, even between temporally separated viruses and suggests local perpetuation of the viruses. The past decades have witnessed an increase in the incidence of IAV outbreaks in poultry in Europe and zoonotic transmission of a growing number of subtypes. Surveillance data of IAV in the natural host is important for designing efficient national policies aiming to control the transmission of IAV to susceptible populations and for risk assessment. Our results also show that the northern breeding sites have implications on a European scale.
  • Outinen, Sami (Into Kustannus Oy, 2015)
    Abstract The study puts into historical context the continuities and discontinuities of the employment concepts and policies of leading social democrats in Finland from 1975 to 1998. It concentrates on the decision-making of the most influential political party in Finland at that time, the Social Democratic Party (SDP). The study applies the methods of social science history and conceptual history by researching both the strategic decision-making and public argumentation of the social democrats. The framework of the analysis is based on regulation theory, which distinguishes five fundamental institutional forms in capitalist societies: (1) the nature of the state (economic, employment and unemployment security policy), (2) the wage-labour nexus (labour market policy),(3) the monetary regime (monetary policy and the regulation of capital markets), (4) the forms of competition (state company, privatisation and competition policy) and (5) international interconnectedness (European integration, economic globalisation as well as the impact of Sweden and international organisations). Finnish social democrats moved towards emphasising private sector-led employment, approached the middle class, adopted monetarist ideas, accepted the market economy and favoured controlled restructuring over counter-cyclical measures in a series of steps in 1975 1998. Export sector competitiveness in global markets, European integration, active labour market policy and R and D investment were the cornerstones of social democratic employment policy in Finland at the time. Finnish social democrats also partly adopted neoliberal practices such as activation, privatisation, financial market deregulation and labour market flexibility. The deregulation of financial markets meant a shifting of the basis of social democratic employment policy from steering the capitalist economy to seeking market acceptance of the party s politics. This did not manage to guarantee full employment in Finland during the period, and exacerbated the poverty of the unemployed. Furthermore, Finnish social democrats practised a third way type of Bad Sillanpää policy long before its adherents such as Tony Blair in the UK. After the mid-1970s, the Finnish social democrat-led governments implemented many reforms which also resembled the premises of the Swedish social democrats Third Way Programme in the 1980s.
  • Nokkonen, Soili (Société Néophilologique, 2015)
    This cumulative dissertation is the first systematic study of semi-modal NEED TO and its semantic variation in Present-day British English. This topic is particularly relevant today, since the use of semi-modals, e.g., HAVE TO, HAVE (GOT) TO and NEED TO has increased in the field of obligation and necessity, while the frequencies of core modals such as MUST and NEED have decreased. The link of modal change with the process of democratization, and the way the semi-modals offer a less authoritarian way of obliging, present an interesting background for a corpus-based sociolinguistic study. The primary material of the five studies in this thesis is drawn from mainly spoken corpora from the 1950s to the 1990s. Both quantitative and qualitative methods are applied in data retrieval and the empirical analyses. The chosen corpora enable the exploration of NEED TO across variables such as real time, medium, the speaker variables of age, gender and social class, and a number of spoken registers. For comparison, Article 5 studies NEED TO and six other modals as variants of deontic obligation. The findings on the semantic variation indicate that the functions of NEED TO increasingly resemble those of core modals: the directive obligation uses cover most of the instances, and NEED TO is in the process of developing epistemic meaning. However, the original inherent necessity sense is still frequent. NEED TO shows clear social stratification. It is strongly favoured by the younger age groups, and they also use the newer semantic functions more. It is slightly more frequent among men in general, but in certain relevant speaker groups, e.g., among young adults, women have a lead. The upper middle class leads in its use. NEED TO is clearly undergoing change, but Labovian concepts cannot be applied in a rigid way. A finding that stands out is that register variation plays a decisive role. NEED TO is significantly more frequent in spoken public contexts as opposed to private contexts. Both the persuasive nature of a register and its high degree of interactivity increase the use of NEED TO. The basic inherent meaning relates to the strategic value of NEED TO in a deontic situation by softening an imposed obligation as being in the addressee s best interest. Indeed, NEED TO has found a niche in the face-to-face conversations where it is necessary to negotiate power and also to oblige the addressee in the least face-threatening manner.
  • Shawesh, Amna Mohammed (Helsingin yliopisto, 2015)
    Indomethacin (IND) is a potent non-steroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, osteoarthritis, acute gout and other disorders. IND is available worldwide mostly in the form of capsules and suppositories, however, these formulations usually create side effects. Consequently, an alternate route of administration to avoid or minimize side effects may be found in the form of semisolid dermatological formulations, now available in few countries. The specific goals of this study were: (I) to determine the solubility of IND using different co-solvents: hexylene glycol (HG), propylene glycol (PG), polyethylene glycol 300 (PEG), butylene glycols (1,2 BG; 1,3 BG and 1,4 BG) and ethanol (ETOH). 1% (w/w) Tween® 80 or polyvinyl pyrrolidone (PVP-25) were used as enhancers; (II) to develop suitable topical gel preparations using 20% (w/w) Pluronic® (PF-127) or 1% (w/w) Carbopol ETD® 2001 (C2001) as gelling agents and HG or PEG 300 as solvents (1% (w/w) Tween® 80 and PVP-25 were added as excipients); (III) To evaluate the effect of composition of prepared gel formulations on the following parameters: appearance, crystallization, pH and rheological behaviour and (IV) to investigate the influence of storage time and storage conditions on the characteristics of the gels. These results indicate that all the solvents tested increased the solubility of IND to varying degrees. Tween® 80 and PVP-25 only slightly enhanced the solubility of IND. 1% (w/w) IND was able to form a structural gel with both PF-127 and C2001. Storing the INDPF-127 gels at 6°C resulted in the precipitation of IND. All gels stored at room temperature exhibited good stability. The gels stored at 45°C developed a dark yellow colour. Gels with C2001 and PF-127/PEG had slightly decreased viscosities with increasing storage time, while the gels with PF-127/HG showed increase in viscosities with time. In conclusion, the water solubility of IND was increased by the addition of co-solvents. 1% (w/w) IND gel can be suitable for using as a gel formulation and it is stable at room temperature. The search for suitable gels for IND topical formulation needs to be continued with more stability studies. Moreover, in-vitro and in-vivo experiments will be necessary for providing data on bioavailability.
  • Kupari, Helena (2015)
    This study examines the lived religion of elderly Finnish Orthodox Christian women in present-day Finland. It discusses the women s everyday religious practice within the domestic environment. Furthermore, it also traces the ways in which their religion had been affected by their life histories, the changing status of the Orthodox community, and the modernization of Finnish society in the course of the 20th century. The primary research material for this study consists of interviews of 24 women. Finland is a Lutheran-dominated country; today, about one percent of Finns belong to the Orthodox Church. Traditionally, most of the Orthodox resided in Finnish Karelia. After the Second World War, Finland had to cede large areas of Karelia to the Soviet Union. In the process, two thirds of the Finnish Orthodox lost their homelands. All the interviewees, or their parents, had been among the evacuees from Karelia. The theoretical-methodological approach made use of in the study is based on practice theory. In particular, the concept of habitus as developed by the sociologist Pierre Bourdieu is applied to analyze the women s interview accounts. The concept captures Bourdieu s understanding of the reciprocal dynamic between practice, subjectivity, and structures of power. The analysis demonstrates that the interviewees religion was characterized by a movement between routine and reflexive action. Judging from the material, they mostly did religion in a habitual fashion. Nevertheless, they could also perform their practices more intentionally, to reinforce their identity against specific others. These two aspects of the women s religion are traced, respectively, to their childhood religious socialization and their social trajectories as minority religious practitioners in Finnish society. Ultimately, the analysis forms an account of the women s religion as habitus. The informants religious habitus constituted an embodied and practical sense of religion, which informed both their routine religious practices and more conscious and creative religious actions. This study provides a description and a theoretical representation of one particular style of contemporary religiosity: the lifelong religion of older lay women. Within recent scholarship on religion, the religion of women of the inter-war generation has not received much attention. This study, moreover, offers a reading of Bourdieuan social theory as applied to the lived religion of minority practitioners. As such, it illustrates the explanatory potential that a Bourdieuan approach can bring to analyses of relatively stable religion.
  • Mainio, Aleksi (Omakustanne, 2015)
    The October Revolution in 1917 led to Europe being divided into two camps. The turmoil in Russia also affected Finland, the territory of which became a safe haven for different counterrevolutionary organisations. It is possible to even talk about an invisible war between Finland and the Soviet Union although officially the countries had reached a peace agreement in 1920. This doctoral thesis examines how different White Russian intelligence and military organisations used the territory of Finland for counterrevolutionary activities between 1918 and 1939. It also discusses the relations of the Finnish Security Police and the Military Intelligence of the General Staff with the underground organisations and the attitude of Finnish authorities towards their illegal activities. No comprehensive research has previously been made on these activities. Nor have the groups operating in Finland been formerly examined in a broader international context. Research on these movements and their operations in Finland has therefore remained fragmented and unconnected with the broader picture of the anti-Bolshevistic activity in Russia and the whole of Europe. One of the main conclusions of this thesis is that the territory of Finland served as a significant base for counterrevolutionary operations. Between 1918 and 1939, White Russian emigrants organised intelligence operations and even terrorist attacks against the Soviet Union from the territory of Finland. These events resulted from the previous history of the country and its geopolitical location close to Leningrad and Moscow as well as from the traditions of Finnish activism. This thesis also shows that the White Russian emigrant organisations were closely linked with Finnish security authorities. Arranging terrorist and intelligence operations against the Soviet Union would have been almost impossible without their active or at least passive support. The General Staff, in particular, and the Finnish Security Police to a certain extent, were ready to tolerate and even support the secret activities of White Russian emigrants under certain conditions. This resulted from their desire to affect the developments in the Soviet Union but also from the great demand for intelligence on the neighbouring country. Without close cooperation with the emigrant organisations this would have been difficult to achieve. Such cooperation was a major risk for Finland and its relations with the Soviet Union. From time to time it might even have brought the countries onto the verge of a military conflict. Soviet propaganda used the support of Finnish authorities to emigrant activists involved in terrorist attack plans to harm the reputation of Finland and to justify the shift towards an increasingly totalitarian system.
  • Mutanen, Anu (2015)
    This dissertation analyses state sovereignty from the point of view of national constitutions in the context of the constitutional pluralism of the EU. The research questions of the study are threefold. 1. What changes has the European Union caused in the conceptions and theories of state sovereignty? 2. How do the constitutions of the EU Member States regulate sovereignty? 3. How have these sovereignty provisions been interpreted in Finland, Germany, Denmark, Sweden, and Estonia in a selection of EU-related national treaty processes? These questions are examined with a combination of theoretical and genealogical methods as well as contextual legal dogmatics and legal comparison. The dissertation demonstrates that the EU, and European constitutionalism in general, has profoundly affected state sovereignty as a matter of national constitutional law. The concept of state sovereignty has met with increasing criticism. Particularly the idea of absolute sovereignty has faced its demise in the EU Member States. Nevertheless, the general scholarly take within constitutional law still holds on to the concept, but provides it with increasingly relative content expressed in different theories of delegated or shared sovereignty. The texts of the EU Member State constitutions, however, still hold on to rather absolute formulations of state sovereignty and are still silent on the EU despite its far-reaching effects on sovereignty. As a result the constitutional provisions on sovereignty have been subject to dynamic interpretation in order to enable the domestic ratification of the EU treaties and their amendments without jeopardising the EU s development. Germany belongs to the group of states whose constitutions do not contain a sovereignty clause and which have well-established empowerment clauses. The interpretations provided by the German Constitutional Court in regard to the EU treaties have at times been very EU critical, and influential: Sweden, for example, has clearly developed its EU regulation through the model provided by Germany. Sweden does not mention state sovereignty in its Constitutions, and its constitutional interpretation has been integration friendly. Denmark has an EU-minimalist Constitution, the rigidity and the strong built-in referendum institution of which has enabled it to negotiate opt-outs to the EU treaties, allowing it to escape certain significant consequences for sovereignty. Estonia is situated at the apex of sovereignty protectionist constitutions, but on the other hand its Supreme Court has adopted a very pro-EU manner of interpretation. Finland used to have one of the most sovereignty-oriented constitutions in the EU. However, during the country s EU membership the constitutional interpretation has shifted from a rigid and formalistic approach to state sovereignty towards emphasising and easing Finland s EU activities and other international cooperation. This development was codified in 2012 in the Constitution of Finland in the form of an EU clause and empowerment clauses. When considering both the textual level of sovereignty regulation and its interpretation in connection to the national EU treaty ratification procedures, the current Finnish constitutional understanding of sovereignty is more integration friendly than that of Germany, Denmark, Sweden, or Estonia. This dissertation argues in favour of a pluralistic understanding of state sovereignty for resolution of the problems related to sovereignty within the EU. In the new pluralistic understanding of state sovereignty, national conceptions of sovereignty are recognised in that they also contain within themselves the possibilities for international cooperation and EU membership, with the accompanying transfer of powers and widening of competences, in order to engender truly pluralistic interaction between the EU and its Member States.
  • Walkila, Sonya (2015)
    The grounds for debate on fundamental rights in the European Union are currently more fruitful than ever. Following the entry into force of the Lisbon Treaty, not only did the Union avail itself with its own Bill of Rights , i.e., the Charter of Fundamental Rights of the European Union, but is also preparing for its accession to the European Convention on Human Rights. By the same token, the Charter was elevated to the same level as other primary EU law. The frequent horizontal effect of fundamental rights in recent case law of the Court of Justice of the European Union is an indication of a stronger presence and the increased significance of fundamental rights in the Union s legal order at the time when the boundaries between the public and private spheres are increasingly blurred. The Court of Justice strives to interpret and apply the law in a way which contributes to a build-up of a coherent case law and conforms to fundamental rights as closely as possible. The immediate source of the jeopardising act or degree of the incurred effects should not prove decisive. Rather, the horizontal effect of fundamental rights contributes to the primacy, unity and effectiveness of European Union law . This study suggests it is feasible to consider the horizontal effect of fundamental rights as they relate to situations where the legal positions of private parties are transformed in the Hohfeldian sense pursuant to the application of those rights by a court in a legal dispute before it. The incurring legal position depends in turn on the degree of enforceability of the fundamental right norm in question. Because of the semantic and structural openness of fundamental right norms they often necessitate the deduction of a more concrete normative content. This concretization of abstract norms makes adjudicating on the basis of fundamental rights a delicate matter, since it gives great power to the courts. Where this power is extended to the area which typically falls in the sphere of private law, it grows even stronger. Besides powerfully serving to enhance the inner coherence and consistency of Union law and offering feasible solutions to legal problems, the horizontal application of fundamental rights implies a move towards a strengthened constitutional phase of the integration process. Arguments on fundamental rights entail much more than just formal or dogmatic disputes over the scope of application of an act of EU law. They touch on fundamental questions relating to the functioning of the Union and its constitutional nature which pertains to the entire legal order of the EU.
  • Bergström, Milla (Suomen kirkkohistoriallinen seura, 2015)
    The Holy See, Poland and the Polish-Ukrainian Tensions in Eastern Galicia, 1921-1931 This study analyzes the principles that guided the Holy See in problems generated by Polish-Ukrainian tensions during the pontificate of Pope Pius XI. The geographical focus is in Poland where Pius XI had acted as apostolic visitor and nuncio only eight months before he ascended the throne of Saint Peter. Poland was declared independent in November 1918, and from the start, the Poles were thrown into competition with the republic s largest minority, the three million Greek Catholic Ukrainians of Eastern Galicia. The Ukrainians reluctance to acknowledge Polish dominance over Eastern Galicia in addition to the government s aspirations to pressure them into being loyal citizens resulted in nationalist tensions that persisted throughout the interwar period. These tensions were also reflected in religious matters, occasionally causing the Holy See to become involved with the incidents between the Polish government and the Greek Catholic Ukrainians. The study is based on the Holy See s primary sources that have been available for consultation since 2006. It provides the first thorough investigation of problems generated by Polish-Ukrainian tensions expressly from the point of view of the Holy See and the principles that influenced its responses. The study shows that the Vatican was guided by three main principles: the safeguarding and uncompromising defense of the rights of the Catholic Church and its freedom of action, adhering to the impartiality of the Holy See, and the promoting of peace between nations and preventing unrest. The principle of defending the rights of the Catholic Church and its freedom of action was a central factor in the decisions of the Holy See, for instance, when Polish officials arrested Greek Catholic priests and intruded into cloisters of nuns in Eastern Galicia. The Holy See responded to these violations by presenting to the Polish government an energetic objection and an official protest. Since the Holy See aimed at protecting the rights of the Greek Catholic Church and not those of the Ukrainians, it did not consider it was endangering its principle of impartiality. The principle of impartiality was inherently connected with the pontiff s role as the supreme spiritual shepherd of the universal Catholic Church. Pope Pius XI emphasized the equal benevolence he felt as the Holy Father of all Catholics towards both Roman Catholic Poles and Greek Catholic Ukrainians. In order to not offend either party, the Holy See could not interfere in the disputes between the Poles and the Ukrainians which were primarily a result of conflicting national interests. The Holy See considered that to remain impartial it was required to abstain from taking a public stance in what it regarded as purely political issues. According to the Holy See these issues included, for instance, the territorial dispute over Eastern Galicia. The Holy See´s principle of promoting peace between nations can be attested, for instance, in the Vatican´s endeavor to guide nationality-conscious bishops and clergy towards Christian fraternity. The Holy See considered as particularly problematic the fact that the nationalism of the Roman Catholic and Greek Catholic clerics inspired them to participate in nationalistic politics, and sometimes they seemed to pay more attention to politics than to saving souls. At the same time the national politics and enmity among the bishops and the clergy caused confusion in the parishioners and disrupted the amicable coexistence between the Poles and the Ukrainians. The Holy See instructed the bishops and priests to set an example by showing moderation and thus promoting peace in Eastern Galicia. The main focus of this study is on the two most difficult challenges brought forth by the Polish-Ukrainian tensions Pius XI faced during his pontificate, which aptly demonstrate the principles of the Holy See. The first of these cases was a dispute between the Holy See and the Polish government concerning the return of the Greek Catholic Metropolitan Andrei Sheptytskyi, considered as an enemy by the Poles, to his Archiepiscopal See of Lviv (Eastern Galicia) from his extended journey abroad in 1923. In this case the emphasis was on the principles of ensuring the rights of the church and promoting peace and preventing unrest between the Poles and the Ukrainians. The second problematic case arising from the Polish-Ukrainian tensions dealt with the violent pacification of Ukrainians in the fall of 1930 ordered by the Prime Minister of Poland Józef Piłsudski. This case was of a political nature and because of that, the Holy See s principle of impartiality significantly affected the Pope s resolutions. Pius XI held the principle of impartiality to bind him even when his conscience told him to publicly express his disapproval of the violence inflicted on Ukrainians.
  • Pohjanpalo, Maria (Unigrafia, 2015)
    This research investigates the interrelation of international investments and the environment. It is a study on fragmentation and how to potentially overcome it in practice through what is called a spectrum approach, in the field of international investment law and international environmental law. In particular the focus is on foreign direct investments. Three research questions are posed. First, why is there an increasing amount of investor-state disputes involving an environmental aspect? Second, is it possible to identify common elements, particular problems and specific rules regarding foreign direct investments which have an environmental aspect, from different sources of law, while also taking into account the element of liability? Finally, how could the risk of conflicts, disputes and any resulting liability be minimized? After the introductory Part I, Part II focuses first on the detailed substance of the research topic, placing it then in the theoretical framework, followed by systemizing the growing and changing regulatory and quasi-regulatory framework of it. In Part III on implementation, relevant existing cases are examined. A practical implementation exercise of the identified rules and elements to a foreign investment in the forest sector is included, to investigate if and how the identified rules and elements would apply. Finally in Part IV discussion on future developments and concluding remarks on the findings are presented. The end product of the research is a compact and practical indicative checklist for states and investors that could serve as a tool in order to minimize as far as possible the risk of disputes and liability. The study demonstrates that due to the fragmented nature of international law, in order to facilitate the functioning of the system there is not one, single solution available. This is particularly the case in relation to the third and final research question. Instead, actions by different actors, in different contexts, levels and temporal phases are required, while ensuring a sufficient dialogue and information flow between these actors.
  • Kullman, Kim (2015)
    Working between and beyond the interdisciplinary areas of childhood studies and children’s geographies, this thesis explores how children learn practices of everyday mobility in metropolitan Helsinki (population 1.4 million). Children’s urban movement has become a contested issue in Euro-American settings due to a range of developments, among them the growth in car traffic, the increase in travel distances to school and the widening influence of risk thinking on cultural understandings of childhood. Such tendencies have conspired to intensify the regulation of children’s engagements with urban environments, thereby circumscribing their agencies and sociabilities. Elaborating a more affirmative account of children’s mobility, this thesis gives prominence to the varied competencies, experiences and knowledges of movement that are already in place in the daily lives of families. Through a close exploration of the actual practices whereby children foster their mobilities, the thesis indicates that some of the current concerns around children’s urban movement are misplaced and that societies need to reconsider how children are involved in the shaping of present and future mobilities. The thesis draws on empirical research in two specific sites where children in Helsinki learn mobility: a model traffic area for 5-10-year-olds and the school journeys of 7-12-year-olds, the first of these providing an entry-point into formal pedagogical practices, the second into informal learning through mundane urban travel. The study has deployed various qualitative and participatory methods—including mobile ethnography, digital picture-making and visual interviews—to create an open-ended and flexible arena for children, parents and educators to experiment with diverse ways of becoming mobile and to convey their experiences of such becomings. Further extending this approach, the thesis allies itself with Donald Woods Winnicott, Daniel Stern, Gilles Deleuze, Bruno Latour and other thinkers to trace out a series of mobility experiments, transformative relational arrangements, which suggest a three-fold argument about mobile learning. First, the thesis develops a detailed account of children’s mobility that eschews generalised assumptions about their agency, stressing instead its dynamic and relational emergence as part of daily practices of movement. Children’s mobility in Helsinki is often constituted in collective experiments that draw together a variety of people and materials, from parents and siblings to zebra crossings and bicycles—all carefully composed to engage children in an equally safe and playful elaboration of their agency in relation to other urban bodies. Describing these heterogeneous set-ups and their intricate workings, the thesis brings out the creativity and diversity of children’s everyday movements. Second, the thesis proposes an affirmative view of children’s mundane mobilities by demonstrating that the experimental forms of learning cultivated by the families and educators in Helsinki contribute to children’s sense of belonging in urban and traffic environments. Such experimental learning speaks of more caring and collaborative styles of movement that this thesis further clarifies in an attempt to develop alternative ways of understanding children’s mobility that bypass some of the control-oriented and risk-averse attitudes surrounding the geographies of childhood in present Euro-American societies. This also enables a closer examination of how mobility experiments could help academics, educators, planners and other professionals to support and stimulate children’s mobility in a manner that enriches their civic agency and participation. Third, the thesis elaborates a methodological argument about the importance for childhood research to move beyond the effort to describe the world as it appears towards a more active and collective experimentation with the ways in which the world could become otherwise, as dealing with ever-complex empirical challenges asks for more dynamic and open-ended modes of working. The thesis indicates that understanding issues such as children’s mobility requires continuous experimentation with concepts, devices and methods so that both researchers and participants have an opportunity to detect and amplify unexplored possibilities in their practices. The areas of childhood studies and children’s geographies, through their interdisciplinary inclinations and sensitivities to human potential and transformation, are particularly well placed to contribute to such an exploration of more responsive forms of engagement.
  • Palola, Tuomas (Suomen Rauhanyhdistysten Keskusyhdistys ry, 2015)
    North American Laestadianism, also known as Apostolic Lutheranism, has been divided by schisms on several occasions, which in turn, have also had an effect on the development of schisms within the revivalist movement in Scandinavia. The revivalist movement s problematic history has been traditionally explained by members of the movement as being caused by the actions of individuals or different doctrines. No comprehensive, scientific study has examined the reasons behind the schisms. Those Laestadians who joined the revivalist movement in the original regions, from which they would later emigrate to North America, did not bring with them a monolithic dogmatic heritage. Into the doctrinal diversity of the Apostolic Lutheran melting pot were added the challenges brought forth by the movement s own independent free church status and Americanization. The revivalist movement s leadership in Fennoscandinavia attempted to guide the North American movement, without understanding the factors that were influencing its development. As a result, the leadership created additional conflicts, which precipitated a schism. The doctrinal views within this lay movement were not developed systematically, but rather situationally. The group formation was influenced by the fact that three different languages were spoken in the regions from which the immigrants departed: Finnish, Swedish and Norwegian. In addition to these languages, the immigrants adapted to English usage in North America. The assimilation process progressed at a different pace with different individuals and groups. Thus, they usually ended up having to respond to challenges without a vision, and as a result, the solutions were pragmatic. The chronologically uneven development of schisms in the revivalist movement s areas of influence in Scandinavia and North America also created a situation in which not all of the groups found a corresponding group on the other continent. This factor caused more tension within the movement. The aforementioned factors shaped from Apostolic Lutheranism, in terms of its identity, practices, organization, doctrinal emphases and group formation, a distinctive form of Laestadianism, which maintained contact with the Old Country . This slowed down the pace of Americanization in Apostolic Lutheranism, more so than in other Finnish American churches, and stoked divisions within Laestadianism in Fennoscandinavia. Thus, Apostolic Lutheranism diverged from the general developmental trends of other immigrant churches. Keywords: Finnish immigration to North America, assimilation, laestadianism,laestadian schisms, the third use of the Law, confession
  • Savolainen, Ulla (Suomen Kansantietouden Tutkijain Seura, 2015)
    As a result of the Winter War (1939 1940) and the Continuation War (1941 1944), Finland ceded territories of Karelia to the Soviet Union. There was a Finnish population of over 400,000 people living in the ceded area at that time, and this population was evacuated to the Finnish side of the new border. The evacuation generated narratives about the evacuation journey. Later on, the evacuation journey has itself become a symbol enriched with meanings, a symbol that seems to characterize memories and reminiscences of Karelian evacuees more than any other theme. The research of the present thesis explores the poetics and rhetorical techniques of reminiscence writings about childhood evacuation journeys. The methodological foundation of the research combines theories of folkloristics, oral history research and narrative research. Memories and reminiscences are a fascinating area to explore because they are, according to the approach used here, the contemporary, personal and also narrative interpretations given to the past as well as rendering the significance the individuals assigned to it. Accordingly, the topic of this research is not so much childhood as it was in the past but childhood as it is formulated in writings at the moment of reminiscing. In the case of former Karelian child evacuees, both childhood and the childhood home are remote in time and in space. Narrative reminiscing operates as a tool for handling and crossing this distance. It is a means of creating and analyzing the relationship between the past, the present and the future. The research reveals three narrative strategies: 1. Truth and history oriented narrative strategy 2. Reflexive narrative strategy 3. Literary narrative strategy These strategies are illustrated through three different ways of how writers describe the evacuation journey. Strategies are also characterized by certain kinds of intertextual connections on the one hand and the writer s different ways of handling time in narration on the other. These narrative strategies are emblematic of the goals and intentions of the individual writers, and their investigation produces an outline of the genre of reminiscence writings. In evacuation journey writings, memories tend to interconnect with concrete points of reference, such as objects, documents, places, bodily experiences or crystallized narratives. In this research, these points are defined as sites of memory. Sites of memory testify, authenticate and reassert the link between the past, the present and the future. The research indicates that in reminiscence writings, sites of memory appear as points for the condensation of memories from different times, which in narration are manifested as temporal leaps and expansions of the plot into several overlapping levels of chronology. In addition, the research explores the significance attached to food and social relations in the writings. Central topics are children s reliance on their parents, their role within the family and peer group, and the dependence of the evacuees on other people s help and benevolence. The research shows that negotiations relating to social and power relations interconnect with more general ethical discourses understandings of right and wrong, good and bad which illustrate a writer s comprehensive experiences of losing his or her home and being an evacuee.
  • Palonen, Eveliina (2015)
    Yersinia pseudotuberculosis infections derive from ingestion of contaminated food or water. Typical symptoms of yersiniosis are fever and abdominal pain resulting from mesenteric lymphadenitis, and immunological sequelae are possible. The pathogen has recently caused several epidemics in Finland through fresh produce. However, the slow growth rate and poor competition of Y. pseudotuberculosis make its detection and isolation demanding. Polymerase chain reaction with primers targeted to virulence genes inv, virF, and yadA is thus often used in detection, although the sequence variability of the virulence genes is unknown. To study genetic variability of the virulence genes, inv, virF, and yadA of 18 Y. pseudotuberculosis strains, and two Yersinia similis strains originating from 12 different countries were sequenced. The greatest sequence variability was detected in yadA, while the variability of inv and virF was limited. The observed variability in yadA may hinder detection using PCR and also impact functional properties of YadA. Furthermore, the commonly used primers targeted to inv can, in addition to Y. pseudotuberculosis, detect Y. similis. Y. pseudotuberculosis tolerates well low temperature and other stressful conditions in the environment and in the food chain. However, information on the stress tolerance mechanisms used by this pathogen is limited. Here, the roles of two-component systems (TCSs), alternative sigma factor σE, and RNA helicase CsdA of Y. pseudotuberculosis IP32953 under stress conditions were studied. The relative expression levels of 54 genes encoding putative TCSs in Y. pseudotuberculosis IP32953 were determined at 3°C and at the optimum growth temperature of 28°C. The relative expression levels of most of the genes were higher at 3°C than at 28°C, and TCS CheA/CheY encoding genes cheA and cheY had the highest relative expression levels at 3°C. Mutational analysis demonstrated the demand for cheA for optimal growth at 3°C. In addition, both cheA and cheY were required for motility. Increased expression of several TCS encoding genes demonstrate that probably in Y. pseudotuberculosis many TCSs play a role in adaptation to low temperatures. In addition, motility seems to be associated with cold tolerance. The role of alternative sigma factor σE under stress conditions was studied by determining relative expression levels of rpoE encoding σE and using mutational analysis. Expression of rpoE was induced under low and high temperatures, acid and alkaline conditions, and osmotic and ethanol stress. Mutation of rpoE impaired or abolished growth at pH 5.0, at 3°C, at 37°C, at 42°C, and at 3% ethanol, demonstrating that functional σE is essential under several stress conditions in Y. pseudotuberculosis IP32953. In addition, the rpoE mutant had a higher minimum and a lower maximum growth temperature than the wild-type strain. Thus, in this pathogen, σE has a significant role in stress tolerance, and it contributes to survival during food processing and storage. The function of a cold-induced RNA helicase CsdA has been unknown in Y. pseudotuberculosis. Investigation of the role of CsdA at 3°C by mutagenesis revealed that CsdA is essential for growth at low temperatures. At the optimum growth temperature of 28°C, no growth defect was seen. Also the minimum growth temperature of one of the mutants was significantly higher than that of the wild-type strain. Thus, CsdA enables the growth of Y. pseudotuberculosis in the food chain by allowing continuous growth at low temperatures. The results demonstrate that the foodborne pathogen Y. pseudotuberculosis counters environmental stress by using TCSs and alternative sigma factor, and by synthesizing cold-induced proteins.
  • Zhang, Yuezhou (Yuezhou Zhang, 2014)
    Bioisosteric replacements are used in drug design during lead generation and optimization processes with the aim to replace one functional group of a known molecule by another while retaining biological activity. The reason to use bioisosteric replacements are typically to optimize bioavailability or reducing toxicity. Phosphate groups represent a paradigm to study bioisosteric replacements. Protein-phosphate interaction plays a critical role during molecular recognition processes, and for example kinases represent one of the largest families of drug targets. However, some challenges exclude phosphate as a promising lead-like building block: i) charged phosphates do not cross molecular membranes; ii) some widely expressed proteins such as phosphatases easily hydrolyze phosphoric acid esters, which lead phosphate-containing ligands to lose their binding affinities before reaching their biological targets; iii) introduction of phosphate groups to parent scaffold is not easy. In the first part of the thesis work, I designed and implemented a computational protocol to mine information about phosphate structural replacements deposited in the Protein Data Bank. I constructed 116, 314, 271, and 42 sets of superimposed proteins where each set contains a reference protein to either POP, AMP, ADP, or ATP as well as a certain number of non-nucleotide ligands. 929 of such ligands are under study. The chemotypes that came out as structural replacements are diverse, ranging from common phosphate isosteres such as carboxyl, amide and squaramide to more surprising moieties such as benzoxaborole and aromatic ring systems. I exemplified some novel examples and interpreted the mechanism behind them. Local structural replacements are circumstance dependent: one chemical group valid in certain set-up cannot necessarily guarantee the success of another. The data from the study is available at http://86.50.168.121/phosphates_LSR.php. In the second part, I synthesized fifteen compounds retaining the adenosine moieties and bearing bioisosteric replacements of the phosphate at the ribose 5'-oxygen to test their stability toward human macro domain protein 1. These compounds are composed of either a squaryldiamide or an amide group as the bioisosteric replacement and/or as a linker. To these groups a variety of substituents were attached: phenyl, benzyl, pyridyl, carboxyl, hydroxy and tetrazolyl. Biological evaluation using differential scanning fluorimetry showed that four compounds stabilized human MDO1 at levels comparable to ADP and one at level comparable to AMP. Virtual screening was also run to identify MDO1 binding ligands. Among 20,000 FIMM database lead-like molecules, 39 compounds were selected for testing and eleven compounds found active based on ADPr and Poly-ADPr competition binding assay. The assay is however not well validated and a second confirmatory assay was conducted using calorimetry. To the best of my knowledge, this is the first report of non-endogenous ligands of the human MDO1. Altogether, this thesis highlights the versatility of molecular recognition processes that accompanies chemical replacements in compounds; this in turns shows the limits of the concepts of molecular similarity and classical bioisosterism that are based on the conservation of molecular interactions.
  • Jaakkola, Salla (Helsingin yliopisto, 2014)
    Extremely saline environments include salt lakes, evaporation ponds, and terrestrial environments, such as salt deserts and underground halite deposits. They are inhabited by halophilic microbes that require salt for living. Cell densities in hypersaline waters can be as high as 107-108 cfu/ml, and most of the cells are archaeal. The number of viruses can be ten times higher than that of the cells. In buried halite, the cell counts are generally low, but viable bacteria and archaea have been isolated from samples up to Permian in age (250-280 million years). Icosahedral tailless virus types seem to be common in hypersaline waters, based on microscopic studies. However, only few such viruses have been isolated and studied. In this thesis Haloarcula hispanica icosahedral virus 2 (HHIV-2) was studied using virological, biochemical, sequencing, lipidomic, and cryo-electron microscopy methods. HHIV-2 infects a halophilic euryarchaeal host and is virulent. It is icosahedral, tailless, and contains an inner membrane. The properties of HHIV-2 were compared to two structurally related viruses: haloarchaeal virus SH1 and thermophilic phage P23-77. The comparison revealed the evolutionary stability of the virion capsid structure, in contrast to the host-interacting structures of viruses. It was also established that different virus capsid assembly pathways can lead to identical capsid architecture. Drill core samples from deeply buried halite deposits were used for isolating halophilic microbes. Nine novel unique archaeal strains belonging to Halobacterium and Halolamina were obtained. No bacteria or viruses could be isolated. Three archaeal isolates from 40 million years old halite were found to be polyploid. Polyploidy is connected to higher mutation resistance, which might positively affect the survival of cells inside halite deposits. One unique isolate was obtained from 123 million years old halite. The complete genomic sequence of this isolate was resolved. Based on sequence data and DNA-DNA hybridization, the isolate represented a novel species, and was named Halobacterium hubeiense. The isolate was found to be closely related to halophilic archaea residing in surface habitats.