Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance

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Wagner , R , Hakaste , L , Ahlqvist , E , Heni , M , Machann , J , Schick , F , Van Obberghen , E , Stefan , N , Gallwitz , B , Tuomi , T , Haering , H-U , Groop , L & Fritsche , A 2017 , ' Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance ' , Diabetes , vol. 66 , no. 5 , pp. 1373-1379 . https://doi.org/10.2337/db16-0354

Title: Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance
Author: Wagner, Robert; Hakaste, Liisa; Ahlqvist, Emma; Heni, Martin; Machann, Juergen; Schick, Fritz; Van Obberghen, Emmanuel; Stefan, Norbert; Gallwitz, Baptist; Tuomi, Tiinamaija; Haering, Hans-Ulrich; Groop, Leif; Fritsche, Andreas
Contributor: University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, Research Programs Unit
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-05-01
Language: eng
Number of pages: 7
Belongs to series: Diabetes
ISSN: 0012-1797
URI: http://hdl.handle.net/10138/183283
Abstract: Glucagon levels are classically suppressed after glucose challenge. It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes. We investigated the association of postchallenge change in glucagon during oral glucose tolerance tests (OGTTs), hypothesizing that higher postchallenge glucagon levels are observed in subjects with impaired glucose tolerance (IGT). Glucagon levels were measured during OGTT in a total of 4,194 individuals without diabetes in three large European cohorts. Longitudinal changes in glucagon suppression were investigated in 50 participants undergoing a lifestyle intervention. Only 66-79% of participants showed suppression of glucagon at 120 min (fold change glucagon(120/0)
Subject: INSULIN-RESISTANCE
FASTING GLUCAGON
SUPPRESSION
SECRETION
3121 General medicine, internal medicine and other clinical medicine
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