Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance
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Wagner , R , Hakaste , L , Ahlqvist , E , Heni , M , Machann , J , Schick , F , Van Obberghen , E , Stefan , N , Gallwitz , B , Tuomi , T , Haering , H-U , Groop , L & Fritsche , A 2017 , ' Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance ' , Diabetes , vol. 66 , no. 5 , pp. 1373-1379 . https://doi.org/10.2337/db16-0354
| Title: | Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance |
| Author: | Wagner, Robert; Hakaste, Liisa; Ahlqvist, Emma; Heni, Martin; Machann, Juergen; Schick, Fritz; Van Obberghen, Emmanuel; Stefan, Norbert; Gallwitz, Baptist; Tuomi, Tiinamaija; Haering, Hans-Ulrich; Groop, Leif; Fritsche, Andreas |
| Contributor: | University of Helsinki, Diabetes and Obesity Research Program University of Helsinki, Research Programs Unit University of Helsinki, Institute for Molecular Medicine Finland |
| Date: | 2017-05-01 |
| Language: | eng |
| Number of pages: | 7 |
| Belongs to series: | Diabetes |
| ISSN: | 0012-1797 |
| URI: | http://hdl.handle.net/10138/183283 |
| Abstract: | Glucagon levels are classically suppressed after glucose challenge. It is still not clear as to whether a lack of suppression contributes to hyperglycemia and thus to the development of diabetes. We investigated the association of postchallenge change in glucagon during oral glucose tolerance tests (OGTTs), hypothesizing that higher postchallenge glucagon levels are observed in subjects with impaired glucose tolerance (IGT). Glucagon levels were measured during OGTT in a total of 4,194 individuals without diabetes in three large European cohorts. Longitudinal changes in glucagon suppression were investigated in 50 participants undergoing a lifestyle intervention. Only 66-79% of participants showed suppression of glucagon at 120 min (fold change glucagon(120/0) |
| Subject: |
INSULIN-RESISTANCE
FASTING GLUCAGON SUPPRESSION SECRETION 3121 General medicine, internal medicine and other clinical medicine |
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Articles from TUHAT CRIS [38568]