Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

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dc.contributor.author de Mello, Vanessa D.
dc.contributor.author Paananen, Jussi
dc.contributor.author Lindstrom, Jaana
dc.contributor.author Lankinen, Maria A.
dc.contributor.author Shi, Lin
dc.contributor.author Kuusisto, Johanna
dc.contributor.author Pihlajamaki, Jussi
dc.contributor.author Auriola, Seppo
dc.contributor.author Lehtonen, Marko
dc.contributor.author Rolandsson, Olov
dc.contributor.author Bergdahl, Ingvar A.
dc.contributor.author Nordin, Elise
dc.contributor.author Ilanne-Parikka, Pirjo
dc.contributor.author Keinanen-Kiukaanniemi, Sirkka
dc.contributor.author Landberg, Rikard
dc.contributor.author Eriksson, Johan G.
dc.contributor.author Tuomilehto, Jaakko
dc.contributor.author Hanhineva, Kati
dc.contributor.author Uusitupa, Matti
dc.date.accessioned 2017-05-09T06:42:01Z
dc.date.available 2017-05-09T06:42:01Z
dc.date.issued 2017-04-11
dc.identifier.citation de Mello , V D , Paananen , J , Lindstrom , J , Lankinen , M A , Shi , L , Kuusisto , J , Pihlajamaki , J , Auriola , S , Lehtonen , M , Rolandsson , O , Bergdahl , I A , Nordin , E , Ilanne-Parikka , P , Keinanen-Kiukaanniemi , S , Landberg , R , Eriksson , J G , Tuomilehto , J , Hanhineva , K & Uusitupa , M 2017 , ' Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study ' , Scientific Reports , vol. 7 , 46337 . https://doi.org/10.1038/srep46337
dc.identifier.other PURE: 83973151
dc.identifier.other PURE UUID: a1b79d44-3e77-45ef-92e7-077a4c5bb246
dc.identifier.other WOS: 000398828100001
dc.identifier.other Scopus: 85017387045
dc.identifier.uri http://hdl.handle.net/10138/183446
dc.description.abstract Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of alpha-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject IMPAIRED GLUCOSE-TOLERANCE
dc.subject INSULIN SENSITIVITY
dc.subject INDOLE-3-PROPIONIC ACID
dc.subject MASS-SPECTROMETRY
dc.subject INDOLIC COMPOUNDS
dc.subject GUT MICROBIOTA
dc.subject AMINO-ACIDS
dc.subject FATTY-ACIDS
dc.subject LIFE-STYLE
dc.subject BIOMARKERS
dc.subject 3111 Biomedicine
dc.title Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Johan Eriksson / Principal Investigator
dc.contributor.organization Department of General Practice and Primary Health Care
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/srep46337
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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