Estrogen receptors in ovarian granulosa cell tumors

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http://urn.fi/URN:NBN:fi:hulib-201705104071
Title: Estrogen receptors in ovarian granulosa cell tumors
Author: Mäkinen, Lotta
Contributor: University of Helsinki, Faculty of Medicine
Publisher: Helsingin yliopisto
Date: 2017
Language: eng
URI: http://urn.fi/URN:NBN:fi:hulib-201705104071
http://hdl.handle.net/10138/184200
Thesis level: master's thesis
Discipline: Obstetrics and Gynecology
Naistentaudit ja synnytykset
Kvinnosjukdomar och förlossningar
Abstract: Granulosa cell tumor (GCT) is a rare ovarian malignancy, which is considered to be of low malignant potential but has a tendency to recurrence. In this study, we studied the variation of estrogen receptors in adult type GCTs in correlation with clinical data. A tumor tissue microarray containing 194 AGCT tumor samples was immunostained with antibodies against ER-β and GPER1. 93% of the tumors expressed ER-β in either their nucleus (47%) or cytoplasm (78%), and 94% of tumors expressed GPER1. The cytoplasmic expressions of ER-β and GPER1 correlated positively. Nuclear expression of ER-β was more abundant than cytoplasmic expression in tumors from premenopausal women, when compared to tumors from postmenopausal women. Overall survival tended to be worse for patients with high GPER1 expression. On the basis of these findings, we prove that AGCTs have different estrogen receptor profiles that may have an impact on clinical findings.


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