Patterns in the skin microbiota differ in children and teenagers between rural and urban environments

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Lehtimaki , J , Karkman , A , Laatikainen , T , Paalanen , L , von Hertzen , L , Haahtela , T , Hanski , I & Ruokolainen , L 2017 , ' Patterns in the skin microbiota differ in children and teenagers between rural and urban environments ' , Scientific Reports , vol. 7 , 45651 . https://doi.org/10.1038/srep45651

Title: Patterns in the skin microbiota differ in children and teenagers between rural and urban environments
Author: Lehtimaki, Jenni; Karkman, Antti; Laatikainen, Tiina; Paalanen, Laura; von Hertzen, Leena; Haahtela, Tari; Hanski, Ilkka; Ruokolainen, Lasse
Contributor organization: Biosciences
Centre of Excellence in Metapopulation Research
Department of Dermatology, Allergology and Venereology
Clinicum
Veijo Kaitala / Principal Investigator
Ilkka Hanski / Principal Investigator
HUS Inflammation Center
Date: 2017-03-31
Language: eng
Number of pages: 11
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep45651
URI: http://hdl.handle.net/10138/187954
Abstract: The composition of human microbiota is affected by a multitude of factors. Understanding the dynamics of our microbial communities is important for promoting human health because microbiota has a crucial role in the development of inflammatory diseases, such as allergies. We have studied the skin microbiota of both arms in 275 Finnish children of few months old to teenagers living in contrasting environments. We show that while age is a major factor affecting skin microbial composition, the living environment also discriminates the skin microbiota of rural and urban children. The effect of environment is age-specific; it is most prominent in toddlers but weaker for newborns and non-existent for teenagers. Within-individual variation is also related to age and environment. Surprisingly, variation between arms is smaller in rural subjects in all age groups, except in teenagers. We also collected serum samples from children for characterization of allergic sensitization and found a weak, but significant association between allergic sensitization and microbial composition. We suggest that physiological and behavioral changes, related to age and the amount of contact with environmental microbiota, jointly influence the dynamics of the skin microbiota, and explain why the association between the living environment skin microbiota is lost in teenager.
Subject: HUMAN GUT MICROBIOME
BACTERIAL COMMUNITIES
DIVERSITY
IMMUNITY
LIFE
DISEASE
HEALTH
SENSITIZATION
BIODIVERSITY
INFLAMMATION
1183 Plant biology, microbiology, virology
119 Other natural sciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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