Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth

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Girchenko , P , Lahti , J , Czamara , D , Knight , A K , Jones , M J , Suarez Figueiredo , A , Hämäläinen , E , Kajantie , E , Laivuori , H , Villa , P M , Reynolds , R M , Kobor , M S , Smith , A K , Binder , E B & Räikkönen , K 2017 , ' Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth ' , Clinical epigenetics , vol. 9 , 49 . https://doi.org/10.1186/s13148-017-0349-z

Title: Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth
Author: Girchenko, Polina; Lahti, Jari; Czamara, Darina; Knight, Anna K.; Jones, Meaghan J.; Suarez Figueiredo, Anna; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Kobor, Michael S.; Smith, Alicia K.; Binder, Elisabeth B.; Räikkönen, Katri
Other contributor: University of Helsinki, Medicum
University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Children's Hospital
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Medicum















Date: 2017-05-08
Language: eng
Number of pages: 14
Belongs to series: Clinical epigenetics
ISSN: 1868-7083
DOI: https://doi.org/10.1186/s13148-017-0349-z
URI: http://hdl.handle.net/10138/189039
Abstract: Background: A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. These characteristics reflect prenatal environmental adversity and are expected to influence newborn developmental stage. Results: DNAm GA acceleration (GAA; i.e., older DNAm GA than chronological GA) of the offspring at birth was associated with maternal age of over 40 years at delivery, pre-eclampsia and fetal demise in a previous pregnancy, maternal pre-eclampsia and treatment with antenatal betamethasone in the index pregnancy, lower neonatal birth size, lower 1-min Apgar score, and female sex. DNAm GA deceleration (GAD; i.e., younger DNAm GA than chronological GA) of the offspring at birth was associated with insulin-treated gestational diabetes mellitus (GDM) in a previous pregnancy and Sjogren's syndrome. These findings were more accentuated when the DNAm GA calculation was based on the raw difference between DNAm GA and GA than on the residual from the linear regression of DNAm GA on GA. Conclusions: Our findings show that variations in the DNAm GA of the offspring at birth are associated with a number of maternal and offspring characteristics known to reflect exposure to prenatal environmental adversity. Future studies should be aimed at determining if this biological variation is predictive of developmental adversity.
Subject: Aging
Cord blood methylation
Epigenetic clock
Gestational age
Prenatal programming
CORONARY-HEART-DISEASE
DNA METHYLATION
EARLY-LIFE
CHRONOLOGICAL AGE
ADULT DISEASE
HUMAN BRAIN
CELL-TYPES
BODY-MASS
COHORT
WEIGHT
3122 Cancers
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