Investigating the causal effect of smoking on hay fever and asthma : a Mendelian randomization meta-analysis in the CARTA consortiumn

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Skaaby , T , Taylor , A E , Jacobsen , R K , Paternoster , L , Thuesen , B H , Ahluwalia , T S , Larsen , S C , Zhou , A , Wong , A , Gabrielsen , M E , Bjorngaard , J H , Flexeder , C , Mannisto , S , Hardy , R , Kuh , D , Barry , S J , Mollehave , L T , Cerqueira , C , Friedrich , N , Bonten , T N , Noordam , R , Mook-Kanamori , D O , Taube , C , Jessen , L E , McConnachie , A , Sattar , N , Upton , M N , McSharry , C , Bonnelykke , K , Bisgaard , H , Schulz , H , Strauch , K , Meitinger , T , Peters , A , Grallert , H , Nohr , E A , Kivimaki , M , Kumari , M , Voelker , U , Nauck , M , Voeizke , H , Power , C , Hypponen , E , Hansen , T , Jorgensen , T , Pedersen , O , Salomaa , V , Grarup , N , Langhammer , A , Romundstad , P R , Skorpen , F , Kaprio , J , Munafo , M R & Linneberg , A 2017 , ' Investigating the causal effect of smoking on hay fever and asthma : a Mendelian randomization meta-analysis in the CARTA consortiumn ' , Scientific Reports , vol. 7 , 2224 . https://doi.org/10.1038/s41598-017-01977-w

Title: Investigating the causal effect of smoking on hay fever and asthma : a Mendelian randomization meta-analysis in the CARTA consortiumn
Author: Skaaby, Tea; Taylor, Amy E.; Jacobsen, Rikke K.; Paternoster, Lavinia; Thuesen, Betina H.; Ahluwalia, Tarunveer S.; Larsen, Sofus C.; Zhou, Ang; Wong, Andrew; Gabrielsen, Maiken E.; Bjorngaard, Johan H.; Flexeder, Claudia; Mannisto, Satu; Hardy, Rebecca; Kuh, Diana; Barry, Sarah J.; Mollehave, Line Tang; Cerqueira, Charlotte; Friedrich, Nele; Bonten, Tobias N.; Noordam, Raymond; Mook-Kanamori, Dennis O.; Taube, Christian; Jessen, Leon E.; McConnachie, Alex; Sattar, Naveed; Upton, Mark N.; McSharry, Charles; Bonnelykke, Klaus; Bisgaard, Hans; Schulz, Holger; Strauch, Konstantin; Meitinger, Thomas; Peters, Annette; Grallert, Harald; Nohr, Ellen A.; Kivimaki, Mika; Kumari, Meena; Voelker, Uwe; Nauck, Matthias; Voeizke, Henry; Power, Chris; Hypponen, Elina; Hansen, Torben; Jorgensen, Torben; Pedersen, Oluf; Salomaa, Veikko; Grarup, Niels; Langhammer, Arnulf; Romundstad, Pal R.; Skorpen, Frank; Kaprio, Jaakko; Munafo, Marcus R.; Linneberg, Allan
Contributor: University of Helsinki, Clinicum
Date: 2017-05-22
Language: eng
Number of pages: 9
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/190713
Abstract: Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0.68, 95% confidence interval (CI): 0.61, 0.76; P <0.001) and allergic sensitization (OR = 0.74, 95% CI: 0.64, 0.86; P <0.001), but similar asthma risk (OR = 1.00, 95% CI: 0.91, 1.09; P = 0.967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0.958, 95% CI: 0.920, 0.998; P = 0.041), a lower risk of allergic sensitization (OR = 0.92, 95% CI: 0.84, 1.02; P = 0.117), but higher risk of asthma (OR = 1.06, 95% CI: 1.01, 1.11; P = 0.020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
Subject: OBSTRUCTIVE PULMONARY-DISEASE
CIGARETTE-SMOKING
ALLERGIC SENSITIZATION
NICOTINE DEPENDENCE
GENERAL-POPULATION
COPENHAGEN ALLERGY
GENETIC-VARIANTS
LUNG-FUNCTION
ASSOCIATION
ADULTS
3111 Biomedicine
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