Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers

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http://hdl.handle.net/10138/192019

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Badeau , R M , Honka , M-J , Bucci , M , Iozzo , P , Eriksson , J G & Nuutila , P 2017 , ' Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers ' , Nutrients , vol. 9 , no. 2 , 110 . https://doi.org/10.3390/nu9020110

Title: Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers
Author: Badeau, Robert M.; Honka, Miikka-Juhani; Bucci, Marco; Iozzo, Patricia; Eriksson, Johan G.; Nuutila, Pirjo
Contributor: University of Helsinki, Clinicum
Date: 2017-02
Language: eng
Number of pages: 8
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/192019
Abstract: Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabolite profiles in elderly women who were either female offspring from obese mothers (OOM) or offspring of lean mothers (OLM). Metabolic changes were tested for associations with metrics for insulin resistance. Methods: Thirty-seven elderly women were separated into elderly offspring from obese mothers (OOM; n = 17) and elderly offspring from lean/normal weight mothers (OLM; n = 20) groups. We measured plasma metabolites using proton nuclear magnetic resonance (1H-NMR) and insulin-dependent tissue-specific glucose uptake in skeletal muscle was assessed. Associations were made between metabolites and glucose uptake. Results: Compared to the OLM group, we found that the docosahexaenoic acid percentage of the total long-chain n-3 fatty acids (DHA/FA) was significantly lower in OOM (p = 0.015). DHA/FA associated significantly with skeletal muscle glucose uptake (GU) (p = 0.031) and the metabolizable glucose value derived from hyperinsulinemic-euglycemic clamp technique (M-value) in the OLM group only (p = 0.050). Conclusions: DHA/FA is associated with insulin-dependent skeletal muscle glucose uptake and this association is significantly weakened in the offspring of obese mothers.
Subject: 22: 6 docosahexaenoic acid
omega-3 fatty acids
offspring of obese mothers
offspring of lean mothers
insulin-dependent skeletal muscle glucose uptake
METABOLIC SYNDROME
DIABETES-MELLITUS
MATERNAL OBESITY
BRANCHED-CHAIN
RESISTANCE
PREDICTORS
HUMANS
ADULTS
TRENDS
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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