Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers

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dc.contributor.author Badeau, Robert M.
dc.contributor.author Honka, Miikka-Juhani
dc.contributor.author Bucci, Marco
dc.contributor.author Iozzo, Patricia
dc.contributor.author Eriksson, Johan G.
dc.contributor.author Nuutila, Pirjo
dc.date.accessioned 2017-06-16T08:11:02Z
dc.date.available 2017-06-16T08:11:02Z
dc.date.issued 2017-02
dc.identifier.citation Badeau , R M , Honka , M-J , Bucci , M , Iozzo , P , Eriksson , J G & Nuutila , P 2017 , ' Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers ' , Nutrients , vol. 9 , no. 2 , 110 . https://doi.org/10.3390/nu9020110
dc.identifier.other PURE: 85649224
dc.identifier.other PURE UUID: 2bdb243c-f25a-4a01-9a05-95127043b2d5
dc.identifier.other WOS: 000397023100023
dc.identifier.other Scopus: 85012071194
dc.identifier.uri http://hdl.handle.net/10138/192019
dc.description.abstract Background: Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. The circulating metabolites that are related to insulin resistance and are associated with this decreased tissue-specific uptake are unknown. Here, we assessed metabolite profiles in elderly women who were either female offspring from obese mothers (OOM) or offspring of lean mothers (OLM). Metabolic changes were tested for associations with metrics for insulin resistance. Methods: Thirty-seven elderly women were separated into elderly offspring from obese mothers (OOM; n = 17) and elderly offspring from lean/normal weight mothers (OLM; n = 20) groups. We measured plasma metabolites using proton nuclear magnetic resonance (1H-NMR) and insulin-dependent tissue-specific glucose uptake in skeletal muscle was assessed. Associations were made between metabolites and glucose uptake. Results: Compared to the OLM group, we found that the docosahexaenoic acid percentage of the total long-chain n-3 fatty acids (DHA/FA) was significantly lower in OOM (p = 0.015). DHA/FA associated significantly with skeletal muscle glucose uptake (GU) (p = 0.031) and the metabolizable glucose value derived from hyperinsulinemic-euglycemic clamp technique (M-value) in the OLM group only (p = 0.050). Conclusions: DHA/FA is associated with insulin-dependent skeletal muscle glucose uptake and this association is significantly weakened in the offspring of obese mothers. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Nutrients
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 22: 6 docosahexaenoic acid
dc.subject omega-3 fatty acids
dc.subject offspring of obese mothers
dc.subject offspring of lean mothers
dc.subject insulin-dependent skeletal muscle glucose uptake
dc.subject METABOLIC SYNDROME
dc.subject DIABETES-MELLITUS
dc.subject MATERNAL OBESITY
dc.subject BRANCHED-CHAIN
dc.subject RESISTANCE
dc.subject PREDICTORS
dc.subject HUMANS
dc.subject ADULTS
dc.subject TRENDS
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3123 Gynaecology and paediatrics
dc.title Circulating Docosahexaenoic Acid Associates with Insulin-Dependent Skeletal Muscle and Whole Body Glucose Uptake in OlderWomen Born from Normal Weight Mothers en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Johan Eriksson / Principal Investigator
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/nu9020110
dc.relation.issn 2072-6643
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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