Enhanced Memory Consolidation Via Automatic Sound Stimulation During Non-REM Sleep

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Leminen , M M , Virkkala , J , Saure , E , Paajanen , T , Zee , P C , Santostasi , G , Hublin , C , Müller , K , Porkka-Heiskanen , T , Huotilainen , M & Paunio , T 2017 , ' Enhanced Memory Consolidation Via Automatic Sound Stimulation During Non-REM Sleep ' , Sleep , vol. 40 , no. 3 , 003 . https://doi.org/10.1093/sleep/zsx003

Title: Enhanced Memory Consolidation Via Automatic Sound Stimulation During Non-REM Sleep
Author: Leminen, Miika M.; Virkkala, Jussi; Saure, Emma; Paajanen, Teemu; Zee, Phyllis C.; Santostasi, Giovanni; Hublin, Christer; Müller, Kiti; Porkka-Heiskanen, Tarja; Huotilainen, Minna; Paunio, Tiina
Contributor organization: Medicum
Cognitive Brain Research Unit
Department of Psychology and Logopedics
Korva-, nenä- ja kurkkutautien klinikka
Tarja Stenberg / Principal Investigator
Department of Physiology
CICERO Learning
Department of Psychiatry
AGORA for the study of social justice and equality in education -research centre
Brain, Music and Learning
Date: 2017-03-01
Language: eng
Number of pages: 10
Belongs to series: Sleep
ISSN: 0161-8105
DOI: https://doi.org/10.1093/sleep/zsx003
URI: http://hdl.handle.net/10138/194797
Abstract: Introduction: Slow-wave sleep (SWS) slow waves and sleep spindle activity have been shown to be crucial for memory consolidation. Recently, memory consolidation has been causally facilitated in human participants via auditory stimuli phase-locked to SWS slow waves. Aims: Here, we aimed to develop a new acoustic stimulus protocol to facilitate learning and to validate it using different memory tasks. Most importantly, the stimulation setup was automated to be applicable for ambulatory home use. Methods: Fifteen healthy participants slept 3 nights in the laboratory. Learning was tested with 4 memory tasks (word pairs, serial finger tapping, picture recognition, and face-name association). Additional questionnaires addressed subjective sleep quality and overnight changes in mood. During the stimulus night, auditory stimuli were adjusted and targeted by an unsupervised algorithm to be phase-locked to the negative peak of slow waves in SWS. During the control night no sounds were presented. Results: Results showed that the sound stimulation increased both slow wave (p =.002) and sleep spindle activity (p Conclusions: We showed that the memory effect of the SWS-targeted individually triggered single-sound stimulation is specific to verbal associative memory. Moreover, the ambulatory and automated sound stimulus setup was promising and allows for a broad range of potential follow-up studies in the future.
Subject: EEG
acoustic stimulation
slow-wave sleep
auditory-evoked K-complex
515 Psychology
516 Educational sciences
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: publishedVersion

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