Ltbp4 regulates Pdgfr beta expression via TGF beta-dependent modulation of Nrf2 transcription factor function

Show simple item record Tomasovic, Ana Kurrle, Nina Wempe, Frank De-Zolt, Siike Scheibe, Susan Koli, Katri Serchinger, Martin Schnuetgen, Frank Sueruen, Duran Sterner-Kock, Anja Weissmann, Norbert von Meichner, Harald 2017-06-28T12:06:01Z 2017-06-28T12:06:01Z 2017-05
dc.identifier.citation Tomasovic , A , Kurrle , N , Wempe , F , De-Zolt , S , Scheibe , S , Koli , K , Serchinger , M , Schnuetgen , F , Sueruen , D , Sterner-Kock , A , Weissmann , N & von Meichner , H 2017 , ' Ltbp4 regulates Pdgfr beta expression via TGF beta-dependent modulation of Nrf2 transcription factor function ' , Matrix Biology , vol. 59 , pp. 109-120 .
dc.identifier.other PURE: 86160540
dc.identifier.other PURE UUID: 22c4124e-110f-4e3c-b49a-d8fdbb576cd6
dc.identifier.other WOS: 000399510100008
dc.identifier.other Scopus: 84994491924
dc.description.abstract Latent transforming growth factor beta binding protein 4 (LTBP4) belongs to the fibrillin/LTBP family of proteins and plays an important role as a structural component of extracellular matrix (ECM) and local regulator of TGF beta signaling. We have previously reported that Ltbp4S knock out mice (Ltbp4S-/-) develop centrilobular emphysema reminiscent of late stage COPD, which could be partially rescued by inactivating the antioxidant protein Sestrin 2 (Sesn2). More recent studies showed that Sesn2 knock out mice upregulate Pdgfr beta-controlled alveolar maintenance programs that protect against cigarette smoke induced pulmonary emphysema. Based on this, we hypothesized that the emphysema of Ltbp4S-/- mice is primarily caused by defective Pdgfr beta signaling. Here we show that LTBP4 induces Pdgfr beta signaling by inhibiting the antioxidant Nr12/Keap1 pathway in a TGF beta-dependent manner. Overall, our data identified Ltbp4 as a major player in lung remodeling and injury repair. (C) 2016 The Authors. Published by Elsevier B.V. en
dc.format.extent 12
dc.language.iso eng
dc.relation.ispartof Matrix Biology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Ltbp4
dc.subject Tgf beta
dc.subject Pdgfr beta
dc.subject Nrf2
dc.subject ROS
dc.subject Emphysema
dc.subject C-MYC
dc.subject ACTIVATION
dc.subject BINDING
dc.subject FIBROBLASTS
dc.subject RECEPTOR
dc.subject LUNG
dc.subject 3111 Biomedicine
dc.title Ltbp4 regulates Pdgfr beta expression via TGF beta-dependent modulation of Nrf2 transcription factor function en
dc.type Article
dc.contributor.organization Research Programs Unit
dc.contributor.organization Translational Cancer Biology (TCB) Research Programme
dc.contributor.organization Katri Koli / Principal Investigator
dc.contributor.organization University of Helsinki
dc.contributor.organization Medicum
dc.contributor.organization Transplantation Laboratory
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0945-053X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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