Outcome of intracerebral hemorrhage associated with different oral anticoagulants

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dc.contributor.author Wilson, Duncan
dc.contributor.author Seiffge, David J.
dc.contributor.author Traenka, Christopher
dc.contributor.author Basir, Ghazala
dc.contributor.author Purrucker, Jan C.
dc.contributor.author Rizos, Timolaos
dc.contributor.author Sobowale, Oluwaseun A.
dc.contributor.author Sallinen, Hanne
dc.contributor.author Yeh, Shin-Joe
dc.contributor.author Wu, Teddy Y.
dc.contributor.author Ferrigno, Marc
dc.contributor.author Houben, Rik
dc.contributor.author Schreuder, Floris H. B. M.
dc.contributor.author Perry, Luke A.
dc.contributor.author Tanaka, Jun
dc.contributor.author Boulanger, Marion
dc.contributor.author Salman, Rustam Al-Shahi
dc.contributor.author Jaeger, Hans R.
dc.contributor.author Ambler, Gareth
dc.contributor.author Shakeshaft, Clare
dc.contributor.author Yakushiji, Yusuke
dc.contributor.author Choi, Philip M. C.
dc.contributor.author Staals, Julie
dc.contributor.author Cordonnier, Charlotte
dc.contributor.author Jeng, Jiann-Shing
dc.contributor.author Veltkamp, Roland
dc.contributor.author Dowlatshahi, Dar
dc.contributor.author Engelter, Stefan T.
dc.contributor.author Parry-Jones, Adrian R.
dc.contributor.author Meretoja, Atte
dc.contributor.author Werring, David J.
dc.contributor.author CROMIS-2 Collaborators
dc.date.accessioned 2017-06-29T12:58:01Z
dc.date.available 2017-06-29T12:58:01Z
dc.date.issued 2017-05-02
dc.identifier.citation Wilson , D , Seiffge , D J , Traenka , C , Basir , G , Purrucker , J C , Rizos , T , Sobowale , O A , Sallinen , H , Yeh , S-J , Wu , T Y , Ferrigno , M , Houben , R , Schreuder , F H B M , Perry , L A , Tanaka , J , Boulanger , M , Salman , R A-S , Jaeger , H R , Ambler , G , Shakeshaft , C , Yakushiji , Y , Choi , P M C , Staals , J , Cordonnier , C , Jeng , J-S , Veltkamp , R , Dowlatshahi , D , Engelter , S T , Parry-Jones , A R , Meretoja , A , Werring , D J & CROMIS-2 Collaborators 2017 , ' Outcome of intracerebral hemorrhage associated with different oral anticoagulants ' , Neurology , vol. 88 , no. 18 , pp. 1693-1700 . https://doi.org/10.1212/WNL.0000000000003886
dc.identifier.other PURE: 86209455
dc.identifier.other PURE UUID: c7cdc0cd-a333-4af1-981d-30e5f201c69c
dc.identifier.other WOS: 000400330500006
dc.identifier.other Scopus: 85019643481
dc.identifier.other ORCID: /0000-0001-6433-1931/work/34564604
dc.identifier.uri http://hdl.handle.net/10138/195658
dc.description.abstract Objective: In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral anticoagulation-related ICH (NOAC-ICH) and vitamin K antagonist-associated ICH (VKA-ICH). Methods: We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score 33% or >6 mL from baseline within 72 hours. Results: We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6-38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0-27.9) for VKA-ICH (p = 0.78). We did not find any difference between NOAC-ICH and VKA-ICH for all-cause mortality within 90 days (33% for NOAC-ICH vs 31% for VKA-ICH [p = 0.64]; adjusted Cox hazard ratio (for NOAC-ICH vs VKA-ICH) 0.93 [95% confidence interval (CI) 0.52-1.64] [p = 0.79]), the rate of HE (NOAC-ICH n = 29/48 [40%] vs VKA-ICH n = 93/140 [34%] [p = 0.45]), or functional outcome at hospital discharge (NOAC-ICH vs VKA-ICH odds ratio 0.47; 95% CI 0.18-1.19 [p = 0.11]). Conclusions: In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Neurology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject WARFARIN
dc.subject TRIAL
dc.subject REVERSAL
dc.subject RIVAROXABAN
dc.subject VOLUME
dc.subject MANAGEMENT
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Outcome of intracerebral hemorrhage associated with different oral anticoagulants en
dc.type Article
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization HUS Neurocenter
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1212/WNL.0000000000003886
dc.relation.issn 0028-3878
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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