Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus : a hospital-based cohort study

Show full item record



Permalink

http://hdl.handle.net/10138/196940

Citation

Vilmi-Kerala , T , Lauhio , A , Tervahartiala , T , Palomaki , O , Uotila , J , Sorsa , T & Palomaki , A 2017 , ' Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus : a hospital-based cohort study ' , Cardiovascular Diabetology , vol. 16 , 49 . https://doi.org/10.1186/s12933-017-0530-x

Title: Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus : a hospital-based cohort study
Author: Vilmi-Kerala, Tiina; Lauhio, Anneli; Tervahartiala, Taina; Palomaki, Outi; Uotila, Jukka; Sorsa, Timo; Palomaki, Ari
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-04-13
Language: eng
Number of pages: 10
Belongs to series: Cardiovascular Diabetology
ISSN: 1475-2840
URI: http://hdl.handle.net/10138/196940
Abstract: Background: Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery. We also investigated possible effects of obesity on the results. Methods: We studied two cohorts-120 women with a history of GDM and 120 controls-on average 3.7 years after delivery. Serum concentrations of hsCRP were determined by immunonephelometric and immunoturbidimetric methods, MMP-8 by immunofluorometric assay, and MMP-9 and TIMP-1 by enzyme-linked immunosorbent assays. Pulse wave velocity (PWV) was determined using the foot-to-foot velocity method from carotid and femoral waveforms by using a SphygmoCor device. Arterial compliance was measured non-invasively by an HDI/PulseWave T CR-2000 arterial tonometer. All 240 women were also included in subgroup analyses to study the effect of obesity on the results. Multiple linear regression analyses were performed with adjustment for confounding factors. Results: PWV after pregnancy complicated by GDM was significantly higher than after normal pregnancy, 6.44 +/- 0.83 (SD) vs. 6.17 +/- 0.74 m/s (p = 0.009). Previous GDM was also one of the significant determinants of PWV in multiple linear regression analyses. On the other hand, compliance indices of both large (p = 0.092) and small (p = 0.681) arteries did not differ between the study cohorts. Serum TIMP-1 levels were significantly increased after previous GDM (p = 0.020). However, no differences were found in the serum levels of MMP-8, MMP-9 or hsCRP. In subgroup analyses, there were significantly higher concentrations of hsCRP (p = 0.015) and higher PWV (p <0.001) among obese women compared with non-obese ones. Conclusions: PWV values were significantly higher after GDM compared with normoglycemic pregnancies and were associated with prolonged TIMP-1 upregulation. Cardiovascular risk factors were more common in participants with high BMI than in those with previous GDM.
Subject: Arterial compliance
Gestational diabetes mellitus
High-sensitivity C-reactive protein
Matrix metalloproteinase-8
Matrix metalloproteinase-9
Pulse wave velocity
Subclinical inflammation
Tissue inhibitor of matrix metalloproteinase-1
CONTROLLED CLINICAL-TRIAL
LOW-DENSITY-LIPOPROTEIN
CENTRAL BLOOD-PRESSURE
PULSE-WAVE VELOCITY
C-REACTIVE PROTEIN
METABOLIC SYNDROME
MATRIX METALLOPROTEINASES
ENDOTHELIAL DYSFUNCTION
CARDIOVASCULAR EVENTS
CONSENSUS DOCUMENT
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s12933_017_0530_x.pdf 1.067Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record