European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome - Update 2017

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Trautinger , F , Eder , J , Assaf , C , Bagot , M , Cozzio , A , Dummer , R , Gniadecki , R , Klemke , C-D , Ortiz-Romero , P L , Papadavid , E , Pimpinelli , N , Quaglino , P , Ranki , A , Scarisbrick , J , Stadler , R , Vakeva , L , Vermeer , M H , Whittaker , S , Willemze , R & Knobler , R 2017 , ' European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome - Update 2017 ' , European Journal of Cancer , vol. 77 , pp. 57-74 . https://doi.org/10.1016/j.ejca.2017.02.027

Title: European Organisation for Research and Treatment of Cancer consensus recommendations for the treatment of mycosis fungoides/Sezary syndrome - Update 2017
Author: Trautinger, Franz; Eder, Johanna; Assaf, Chalid; Bagot, Martine; Cozzio, Antonio; Dummer, Reinhard; Gniadecki, Robert; Klemke, Claus-Detlev; Ortiz-Romero, Pablo L.; Papadavid, Evangelia; Pimpinelli, Nicola; Quaglino, Pietro; Ranki, Annamari; Scarisbrick, Julia; Stadler, Rudolf; Vakeva, Liisa; Vermeer, Maarten H.; Whittaker, Sean; Willemze, Rein; Knobler, Robert
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-05
Language: eng
Number of pages: 18
Belongs to series: European Journal of Cancer
ISSN: 0959-8049
URI: http://hdl.handle.net/10138/197451
Abstract: In order to provide a common standard for the treatment of mycosis fungoides (MF) and Sezary syndrome (SS), the European Organisation for Research and Treatment of Cancer-Cutaneous Lymphoma Task Force (EORTC-CLTF) published in 2006 its consensus recommendations for the stage-adapted selection of management options for these neoplasms. Since then, the understanding of the pathophysiology and epidemiology of MF/SS has advanced, the staging system has been revised, new outcome data have been published and novel treatment options have been introduced. The purpose of the present document is to update the original recommendations bearing in mind that there are still only a limited number of controlled studies to support treatment decisions for MF/SS and that often treatment is determined by institutional experience and availability. This consensus on treatment recommendations was established among the authors through a series of consecutive consultations in writing and a round of discussion. Recommended treatment options are presented according to disease stage, whenever possible categorised into first-and second-line options and supported with levels of evidence as devised by the Oxford Centre for Evidence-Based Medicine (OCEBM). Skin-directed therapies are still the most appropriate option for early-stage MF, and most patients can look forward to a normal life expectancy. For patients with advanced disease, prognosis is still grim, and only for a highly selected subset of patients, prolonged survival can be achieved with allogeneic stem cell transplantation (alloSCT). There is a high need for the development and investigation in controlled clinical trials of treatment options that are based on our increasing understanding of the molecular pathology of MF/SS. (C) 2017 The Authors. Published by Elsevier Ltd.
Subject: Mycosis fungoides
Sezary syndrome
Cutaneous T-cell lymphomas
Skin-directed therapy
Total skin electron beam therapy
Radiotherapy
Phototherapy
Chemotherapy
Immunotherapy
Retinoids
T-CELL LYMPHOMA
SKIN ELECTRON-BEAM
PEGYLATED LIPOSOMAL DOXORUBICIN
PHASE-II TRIAL
ORAL METHOXSALEN-PHOTOCHEMOTHERAPY
HISTONE DEACETYLASE INHIBITORS
BONE-MARROW-TRANSPLANTATION
TOPICAL NITROGEN-MUSTARD
LOW-DOSE BEXAROTENE
ALPHA-2A PLUS PUVA
3122 Cancers
3121 General medicine, internal medicine and other clinical medicine
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