Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

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Bogl , L H , Jelenkovic , A , Vuoksimaa , E , Ahrenfeldt , L , Pietilainen , K H , Stazi , M A , Fagnani , C , D'Ippolito , C , Hur , Y-M , Jeong , H-U , Silberg , J L , Eaves , L J , Maes , H H , Bayasgalan , G , Narandalai , D , Cutler , T L , Kandler , C , Jang , K L , Christensen , K , Skytthe , A , Kyvik , K O , Cozen , W , Hwang , A E , Mack , T M , Derom , C A , Vlietinck , R F , Nelson , T L , Whitfield , K E , Corley , R P , Huibregtse , B M , McAdams , T A , Eley , T C , Gregory , A M , Krueger , R F , Mcgue , M , Pahlen , S , Willemsen , G , Bartels , M , van Beijsterveldt , T C E M , Pang , Z , Tan , Q , Zhang , D , Martin , N G , Medland , S E , Montgomery , G W , Hjelmborg , J V B , Rebato , E , Swan , G E , Krasnow , R , Busjahn , A , Lichtenstein , P , Oncel , S Y , Aliev , F , Baker , L A , Tuvblad , C , Siribaddana , S H , Hotopf , M , Sumathipala , A , Rijsdijk , F , Magnusson , P K E , Pedersen , N L , Aslan , A K D , Ordonana , J R , Sanchez-Romera , J F , Colodro-Conde , L , Duncan , G E , Buchwald , D , Tarnoki , A D , Tarnoki , D L , Yokoyama , Y , Hopper , J L , Loos , R J F , Boomsma , D I , Sorensen , T I A , Silventoinen , K & Kaprio , J 2017 , ' Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts ' , Biology of sex differences , vol. 8 , 14 . https://doi.org/10.1186/s13293-017-0134-x

Title: Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts
Author: Bogl, Leonie H.; Jelenkovic, Aline; Vuoksimaa, Eero; Ahrenfeldt, Linda; Pietilainen, Kirsi H.; Stazi, Maria A.; Fagnani, Corrado; D'Ippolito, Cristina; Hur, Yoon-Mi; Jeong, Hoe-Uk; Silberg, Judy L.; Eaves, Lindon J.; Maes, Hermine H.; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Cutler, Tessa L.; Kandler, Christian; Jang, Kerry L.; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten O.; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; Derom, Catherine A.; Vlietinck, Robert F.; Nelson, Tracy L.; Whitfield, Keith E.; Corley, Robin P.; Huibregtse, Brooke M.; McAdams, Tom A.; Eley, Thalia C.; Gregory, Alice M.; Krueger, Robert F.; Mcgue, Matt; Pahlen, Shandell; Willemsen, Gonneke; Bartels, Meike; van Beijsterveldt, Toos C. E. M.; Pang, Zengchang; Tan, Qihua; Zhang, Dongfeng; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Hjelmborg, Jacob van B.; Rebato, Esther; Swan, Gary E.; Krasnow, Ruth; Busjahn, Andreas; Lichtenstein, Paul; Oncel, Sevgi Y.; Aliev, Fazil; Baker, Laura A.; Tuvblad, Catherine; Siribaddana, Sisira H.; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Aslan, Anna K. Dahl; Ordonana, Juan R.; Sanchez-Romera, Juan F.; Colodro-Conde, Lucia; Duncan, Glen E.; Buchwald, Dedra; Tarnoki, Adam D.; Tarnoki, David L.; Yokoyama, Yoshie; Hopper, John L.; Loos, Ruth J. F.; Boomsma, Dorret I.; Sorensen, Thorkild I. A.; Silventoinen, Karri; Kaprio, Jaakko
Contributor organization: Institute for Molecular Medicine Finland
University of Helsinki
Clinicum
Department of Public Health
Department of Social Research (2010-2017)
Center for Population, Health and Society
Diabetes and Obesity Research Program
Research Programs Unit
Endokrinologian yksikkö
Department of Medicine
Sociology
Population Research Unit (PRU)
HUS Abdominal Center
Genetic Epidemiology
Date: 2017-04-27
Language: eng
Number of pages: 12
Belongs to series: Biology of sex differences
ISSN: 2042-6410
DOI: https://doi.org/10.1186/s13293-017-0134-x
URI: http://hdl.handle.net/10138/197455
Abstract: Background: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs. Methods: The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese. Results: OS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance. Conclusions: We found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.
Subject: Prenatal hormone exposure
Opposite-sex twins
Height
Body mass index
CODATwins
POLYCYSTIC-OVARY-SYNDROME
BODY-MASS INDEX
OPPOSITE-SEX
CODATWINS PROJECT
RHESUS-MONKEYS
FEMALE MICE
FETAL SEX
CO-TWINS
TESTOSTERONE
DIMORPHISM
1184 Genetics, developmental biology, physiology
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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