Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis

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dc.contributor University of Helsinki, Institute for Molecular Medicine Finland (FIMM) en
dc.contributor University of Helsinki, Clinicum en
dc.contributor.author Schalekamp-Timmermans, Sarah
dc.contributor.author Arends, Lidia R.
dc.contributor.author Alsaker, Elin
dc.contributor.author Chappell, Lucy
dc.contributor.author Hansson, Stefan
dc.contributor.author Harsem, Nina K.
dc.contributor.author Jalmby, Maya
dc.contributor.author Jeyabalan, Arundhathi
dc.contributor.author Laivuori, Hannele
dc.contributor.author Lawlor, Debbie A.
dc.contributor.author Macdonald-Wallis, Corrie
dc.contributor.author Magnus, Per
dc.contributor.author Myers, Jenny
dc.contributor.author Olsen, Jorn
dc.contributor.author Poston, Lucilla
dc.contributor.author Redman, Christopher W.
dc.contributor.author Staff, Anne C.
dc.contributor.author Villa, Pia
dc.contributor.author Roberts, James M.
dc.contributor.author Steegers, Eric A.
dc.contributor.author Global Pregnancy Collaboration
dc.date.accessioned 2017-07-07T08:31:05Z
dc.date.available 2017-07-07T08:31:05Z
dc.date.issued 2017-04
dc.identifier.citation Schalekamp-Timmermans , S , Arends , L R , Alsaker , E , Chappell , L , Hansson , S , Harsem , N K , Jalmby , M , Jeyabalan , A , Laivuori , H , Lawlor , D A , Macdonald-Wallis , C , Magnus , P , Myers , J , Olsen , J , Poston , L , Redman , C W , Staff , A C , Villa , P , Roberts , J M , Steegers , E A & Global Pregnancy Collaboration 2017 , ' Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis ' International Journal of Epidemiology , vol 46 , no. 2 , pp. 632-642 . DOI: 10.1093/ije/dyw178 en
dc.identifier.issn 0300-5771
dc.identifier.other PURE: 86642533
dc.identifier.other PURE UUID: d1a5d132-7a93-4d12-bdd7-7ee88d98174f
dc.identifier.other WOS: 000402996000052
dc.identifier.uri http://hdl.handle.net/10138/198018
dc.description.abstract Background: Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother,placenta and fetus. This may lead to different adaptive mechanisms during pregnancy. Methods: We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on gestational age at delivery in PE. This was done on 219 575 independent live-born singleton pregnancies, with a gestational age at birth between 22.0 and 43.0 weeks of gestation, from 11 studies participating in a worldwide consortium of international research groups focusing on pregnancy. Results: Of the women, 9033 (4.1%) experienced PE in their pregnancy and 48.8% of the fetuses were female versus 51.2% male. No differences in the female/male distribution were observed with respect to term PE (delivered >= 37 weeks). Preterm PE (delivered <37 weeks) was slightly more prevalent among pregnancies with a female fetus than in pregnancies with a male fetus [odds ratio (OR) 1.11, 95% confidence interval (CI) 1.02-1.21]. Very preterm PE (delivered <34 weeks) was even more prevalent among pregnancies with a female fetus as compared with pregnancies with a male fetus (OR 1.36, 95% CI 1.17-1.59). Conclusions: Sexual dimorphic differences in the occurrence of PE exist, with preterm PE being more prevalent among pregnancies with a female fetus as compared with pregnancies with a male fetus and with no differences with respect to term PE. en
dc.format.extent 11
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof International Journal of Epidemiology
dc.rights CC BY 4.0 en
dc.subject Sexual dimorphism en
dc.subject pre-eclampsia en
dc.subject placenta en
dc.subject sex ratio en
dc.subject ALSPAC en
dc.subject POPULATION-BASED COHORT en
dc.subject HYPEREMESIS GRAVIDARUM en
dc.subject PLACENTAL DYSFUNCTION en
dc.subject GENERATION R en
dc.subject PREGNANCY en
dc.subject WOMEN en
dc.subject RISK en
dc.subject BIRTH en
dc.subject PROFILE en
dc.subject TRIALS en
dc.subject 3142 Public health care science, environmental and occupational health en
dc.subject 3123 Gynaecology and paediatrics en
dc.title Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis en
dc.type A1 Refereed journal article
dc.description.version Peer reviewed
dc.identifier.doi http://dx.doi.org/10.1093/ije/dyw178
dc.type.uri info:eu-repo/semantics/article
dc.type.uri info:eu-repo/semantics/publishedVersion
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