Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

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Graff , M , Scott , R A , Justice , A E , Young , K L , Feitosa , M F , Barata , L , Winkler , T W , Chu , A Y , Mahajan , A , Hadley , D , Xue , L , Workalemahu , T , Heard-Costa , N L , den Hoed , M , Ahluwalia , T S , Qi , Q , Ngwa , J S , Renstrom , F , Quaye , L , Eicher , J D , Hayes , J E , Cornelis , M , Kutalik , Z , Lim , E , Luan , J , Huffman , J E , Zhang , W , Zhao , W , Griffin , P J , Haller , T , Ahmad , S , Marques-Vidal , P M , Bien , S , Yengo , L , Teumer , A , Smith , A V , Kumari , M , Harder , M N , Justesen , J M , Kleber , M E , Hollensted , M , Lohman , K , Rivera , N V , Whitfield , J B , Kristiansson , K , Havulinna , A S , Koistinen , H A , Perola , M , Tuomilehto , J , Kivimaki , M , CHARGE Consortium , EPIC-InterAct Consortium & PAGe Consortium 2017 , ' Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults ' , PLoS Genetics , vol. 13 , no. 4 , 1006528 .

Title: Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Author: Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D.; Hayes, James E.; Cornelis, Marilyn; Kutalik, Zoltan; Lim, Elise; Luan, Jian'an; Huffman, Jennifer E.; Zhang, Weihua; Zhao, Wei; Griffin, Paula J.; Haller, Toomas; Ahmad, Shafqat; Marques-Vidal, Pedro M.; Bien, Stephanie; Yengo, Loic; Teumer, Alexander; Smith, Albert Vernon; Kumari, Meena; Harder, Marie Neergaard; Justesen, Johanne Marie; Kleber, Marcus E.; Hollensted, Mette; Lohman, Kurt; Rivera, Natalia V.; Whitfield, John B.; Kristiansson, Kati; Havulinna, Aki S.; Koistinen, Heikki A.; Perola, Markus; Tuomilehto, Jaakko; Kivimaki, Mika; CHARGE Consortium; EPIC-InterAct Consortium; PAGe Consortium
Contributor organization: University of Helsinki
Institute for Molecular Medicine Finland
Quantitative Genetics
Department of Medicine
Endokrinologian yksikkö
HUS Internal Medicine and Rehabilitation
Complex Disease Genetics
Date: 2017-04
Language: eng
Number of pages: 26
Belongs to series: PLoS Genetics
ISSN: 1553-7404
Abstract: Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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