Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

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dc.contributor University of Helsinki, University of Helsinki en
dc.contributor University of Helsinki, Complex Disease Genetics en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, University of Helsinki en
dc.contributor University of Helsinki, National Institute for Health and Welfare (THL) en
dc.contributor University of Helsinki, University College London en
dc.contributor.author Graff, Mariaelisa
dc.contributor.author Scott, Robert A.
dc.contributor.author Justice, Anne E.
dc.contributor.author Young, Kristin L.
dc.contributor.author Feitosa, Mary F.
dc.contributor.author Barata, Llilda
dc.contributor.author Winkler, Thomas W.
dc.contributor.author Chu, Audrey Y.
dc.contributor.author Mahajan, Anubha
dc.contributor.author Hadley, David
dc.contributor.author Xue, Luting
dc.contributor.author Workalemahu, Tsegaselassie
dc.contributor.author Heard-Costa, Nancy L.
dc.contributor.author den Hoed, Marcel
dc.contributor.author Ahluwalia, Tarunveer S.
dc.contributor.author Qi, Qibin
dc.contributor.author Ngwa, Julius S.
dc.contributor.author Renstrom, Frida
dc.contributor.author Quaye, Lydia
dc.contributor.author Eicher, John D.
dc.contributor.author Hayes, James E.
dc.contributor.author Cornelis, Marilyn
dc.contributor.author Kutalik, Zoltan
dc.contributor.author Lim, Elise
dc.contributor.author Luan, Jian'an
dc.contributor.author Huffman, Jennifer E.
dc.contributor.author Zhang, Weihua
dc.contributor.author Zhao, Wei
dc.contributor.author Griffin, Paula J.
dc.contributor.author Haller, Toomas
dc.contributor.author Ahmad, Shafqat
dc.contributor.author Marques-Vidal, Pedro M.
dc.contributor.author Bien, Stephanie
dc.contributor.author Yengo, Loic
dc.contributor.author Teumer, Alexander
dc.contributor.author Smith, Albert Vernon
dc.contributor.author Kumari, Meena
dc.contributor.author Harder, Marie Neergaard
dc.contributor.author Justesen, Johanne Marie
dc.contributor.author Kleber, Marcus E.
dc.contributor.author Hollensted, Mette
dc.contributor.author Lohman, Kurt
dc.contributor.author Rivera, Natalia V.
dc.contributor.author Whitfield, John B.
dc.contributor.author Kristiansson, Kati
dc.contributor.author Havulinna, Aki S.
dc.contributor.author Koistinen, Heikki A.
dc.contributor.author Perola, Markus
dc.contributor.author Tuomilehto, Jaakko
dc.contributor.author Kivimaki, Mika
dc.contributor.author CHARGE Consortium
dc.contributor.author EPIC-InterAct Consortium
dc.contributor.author PAGE Consortium
dc.date.accessioned 2017-07-07T08:58:02Z
dc.date.available 2017-07-07T08:58:02Z
dc.date.issued 2017-04
dc.identifier.citation Graff , M , Scott , R A , Justice , A E , Young , K L , Feitosa , M F , Barata , L , Winkler , T W , Chu , A Y , Mahajan , A , Hadley , D , Xue , L , Workalemahu , T , Heard-Costa , N L , den Hoed , M , Ahluwalia , T S , Qi , Q , Ngwa , J S , Renstrom , F , Quaye , L , Eicher , J D , Hayes , J E , Cornelis , M , Kutalik , Z , Lim , E , Luan , J , Huffman , J E , Zhang , W , Zhao , W , Griffin , P J , Haller , T , Ahmad , S , Marques-Vidal , P M , Bien , S , Yengo , L , Teumer , A , Smith , A V , Kumari , M , Harder , M N , Justesen , J M , Kleber , M E , Hollensted , M , Lohman , K , Rivera , N V , Whitfield , J B , Kristiansson , K , Havulinna , A S , Koistinen , H A , Perola , M , Tuomilehto , J , Kivimaki , M , CHARGE Consortium , EPIC-InterAct Consortium & PAGE Consortium 2017 , ' Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults ' , PLoS Genetics , vol. 13 , no. 4 , 1006528 . https://doi.org/10.1371/journal.pgen.1006528 en
dc.identifier.issn 1553-7404
dc.identifier.other PURE: 86642981
dc.identifier.other PURE UUID: 35fce286-e4c6-47fe-8764-583272d8f895
dc.identifier.other WOS: 000402549200002
dc.identifier.other Scopus: 85018450983
dc.identifier.uri http://hdl.handle.net/10138/198021
dc.description.abstract Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery. en
dc.format.extent 26
dc.language.iso eng
dc.relation.ispartof PLoS Genetics
dc.rights en
dc.subject BODY-MASS INDEX en
dc.subject REACTIVE PROTEIN-LEVELS en
dc.subject GENE-EXPRESSION en
dc.subject IDENTICAL-TWINS en
dc.subject ADIPOCYTE DIFFERENTIATION en
dc.subject ASSOCIATION METAANALYSIS en
dc.subject ACTIVITY QUESTIONNAIRES en
dc.subject FAT DISTRIBUTION en
dc.subject BINDING PROTEIN en
dc.subject FOOD-INTAKE en
dc.subject 3111 Biomedicine en
dc.subject 1184 Genetics, developmental biology, physiology en
dc.title Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1371/journal.pgen.1006528
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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