Panel 3 : Genetics and Precision Medicine of Otitis Media

Show full item record



Permalink

http://hdl.handle.net/10138/198025

Citation

Lin , J , Hafren , L , Kerschner , J , Li , J-D , Brown , S , Zheng , Q Y , Preciado , D , Nakamura , Y , Huang , Q & Zhang , Y 2017 , ' Panel 3 : Genetics and Precision Medicine of Otitis Media ' , Otolaryngology - Head and Neck Surgery , vol. 156 , pp. S41-S50 . https://doi.org/10.1177/0194599816685559

Title: Panel 3 : Genetics and Precision Medicine of Otitis Media
Author: Lin, Jizhen; Hafren, Lena; Kerschner, Joseph; Li, Jian-Dong; Brown, Steve; Zheng, Qing Y.; Preciado, Diego; Nakamura, Yoshihisa; Huang, Qiuhong; Zhang, Yan
Contributor: University of Helsinki, Clinicum
Date: 2017-04
Language: eng
Number of pages: 10
Belongs to series: Otolaryngology - Head and Neck Surgery
ISSN: 0194-5998
URI: http://hdl.handle.net/10138/198025
Abstract: Objective. The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources. PubMed database of the National Library of Medicine. Review Methods. Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion. Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. Many signaling pathways are involved in the predisposition of otitis media. Implications for Practice. New knowledge on the genetic background relevant to otitis media forms a basis of novel potential interventions, including potential new ways to treat otitis media.
Subject: otitis media
genetics
precision medicine
NONTYPABLE HAEMOPHILUS-INFLUENZAE
EAR EPITHELIAL-CELLS
MORAXELLA-CATARRHALIS
FUNCTIONAL EVIDENCE
TYMPANIC MEMBRANE
URBAN PARTICLES
MOUSE MODEL
TNF-ALPHA
SUSCEPTIBILITY
INFLAMMATION
3125 Otorhinolaryngology, ophthalmology
3126 Surgery, anesthesiology, intensive care, radiology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
0194599816685559.pdf 180.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record