Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis

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Schalekamp-Timmermans , S , Arends , L R , Alsaker , E , Chappell , L , Hansson , S , Harsem , N K , Jalmby , M , Jeyabalan , A , Laivuori , H , Lawlor , D A , Macdonald-Wallis , C , Magnus , P , Myers , J , Olsen , J , Poston , L , Redman , C W , Staff , A C , Villa , P , Roberts , J M , Steegers , E A & Global Pregnancy Collaboration 2017 , ' Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis ' , International Journal of Epidemiology , vol. 46 , no. 2 , pp. 632-642 . https://doi.org/10.1093/ije/dyw178

Title: Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis
Author: Schalekamp-Timmermans, Sarah; Arends, Lidia R.; Alsaker, Elin; Chappell, Lucy; Hansson, Stefan; Harsem, Nina K.; Jalmby, Maya; Jeyabalan, Arundhathi; Laivuori, Hannele; Lawlor, Debbie A.; Macdonald-Wallis, Corrie; Magnus, Per; Myers, Jenny; Olsen, Jorn; Poston, Lucilla; Redman, Christopher W.; Staff, Anne C.; Villa, Pia; Roberts, James M.; Steegers, Eric A.; Global Pregnancy Collaboration
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
Date: 2017-04
Language: eng
Number of pages: 11
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
URI: http://hdl.handle.net/10138/198295
Abstract: Background: Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother,placenta and fetus. This may lead to different adaptive mechanisms during pregnancy. Methods: We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on gestational age at delivery in PE. This was done on 219 575 independent live-born singleton pregnancies, with a gestational age at birth between 22.0 and 43.0 weeks of gestation, from 11 studies participating in a worldwide consortium of international research groups focusing on pregnancy. Results: Of the women, 9033 (4.1%) experienced PE in their pregnancy and 48.8% of the fetuses were female versus 51.2% male. No differences in the female/male distribution were observed with respect to term PE (delivered >= 37 weeks). Preterm PE (delivered <37 weeks) was slightly more prevalent among pregnancies with a female fetus than in pregnancies with a male fetus [odds ratio (OR) 1.11, 95% confidence interval (CI) 1.02-1.21]. Very preterm PE (delivered <34 weeks) was even more prevalent among pregnancies with a female fetus as compared with pregnancies with a male fetus (OR 1.36, 95% CI 1.17-1.59). Conclusions: Sexual dimorphic differences in the occurrence of PE exist, with preterm PE being more prevalent among pregnancies with a female fetus as compared with pregnancies with a male fetus and with no differences with respect to term PE.
Subject: Sexual dimorphism
pre-eclampsia
placenta
sex ratio
ALSPAC
POPULATION-BASED COHORT
HYPEREMESIS GRAVIDARUM
PLACENTAL DYSFUNCTION
GENERATION R
PREGNANCY
WOMEN
RISK
BIRTH
PROFILE
TRIALS
3142 Public health care science, environmental and occupational health
3123 Gynaecology and paediatrics
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