Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis

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Schalekamp-Timmermans , S , Arends , L R , Alsaker , E , Chappell , L , Hansson , S , Harsem , N K , Jalmby , M , Jeyabalan , A , Laivuori , H , Lawlor , D A , Macdonald-Wallis , C , Magnus , P , Myers , J , Olsen , J , Poston , L , Redman , C W , Staff , A C , Villa , P , Roberts , J M , Steegers , E A & Global Pregnancy Collaboration 2017 , ' Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis ' , International Journal of Epidemiology , vol. 46 , no. 2 , pp. 632-642 . https://doi.org/10.1093/ije/dyw178

Title: Fetal sex-specific differences in gestational age at delivery in pre-eclampsia : a meta-analysis
Author: Schalekamp-Timmermans, Sarah; Arends, Lidia R.; Alsaker, Elin; Chappell, Lucy; Hansson, Stefan; Harsem, Nina K.; Jalmby, Maya; Jeyabalan, Arundhathi; Laivuori, Hannele; Lawlor, Debbie A.; Macdonald-Wallis, Corrie; Magnus, Per; Myers, Jenny; Olsen, Jorn; Poston, Lucilla; Redman, Christopher W.; Staff, Anne C.; Villa, Pia; Roberts, James M.; Steegers, Eric A.; Global Pregnancy Collaboration
Contributor organization: Institute for Molecular Medicine Finland
Department of Medical and Clinical Genetics
Pregnancy and Genes
University of Helsinki
Medicum
Clinicum
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Genomics of Neurological and Neuropsychiatric Disorders
Date: 2017-04
Language: eng
Number of pages: 11
Belongs to series: International Journal of Epidemiology
ISSN: 0300-5771
DOI: https://doi.org/10.1093/ije/dyw178
URI: http://hdl.handle.net/10138/198295
Abstract: Background: Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother,placenta and fetus. This may lead to different adaptive mechanisms during pregnancy. Methods: We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on gestational age at delivery in PE. This was done on 219 575 independent live-born singleton pregnancies, with a gestational age at birth between 22.0 and 43.0 weeks of gestation, from 11 studies participating in a worldwide consortium of international research groups focusing on pregnancy. Results: Of the women, 9033 (4.1%) experienced PE in their pregnancy and 48.8% of the fetuses were female versus 51.2% male. No differences in the female/male distribution were observed with respect to term PE (delivered >= 37 weeks). Preterm PE (delivered <37 weeks) was slightly more prevalent among pregnancies with a female fetus than in pregnancies with a male fetus [odds ratio (OR) 1.11, 95% confidence interval (CI) 1.02-1.21]. Very preterm PE (delivered <34 weeks) was even more prevalent among pregnancies with a female fetus as compared with pregnancies with a male fetus (OR 1.36, 95% CI 1.17-1.59). Conclusions: Sexual dimorphic differences in the occurrence of PE exist, with preterm PE being more prevalent among pregnancies with a female fetus as compared with pregnancies with a male fetus and with no differences with respect to term PE.
Subject: Sexual dimorphism
pre-eclampsia
placenta
sex ratio
ALSPAC
POPULATION-BASED COHORT
HYPEREMESIS GRAVIDARUM
PLACENTAL DYSFUNCTION
GENERATION R
PREGNANCY
WOMEN
RISK
BIRTH
PROFILE
TRIALS
3142 Public health care science, environmental and occupational health
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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