Polydrug abuse among opioid maintenance treatment patients is related to inadequate dose of maintenance treatment medicine

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dc.contributor.author Heikman, Pertti K
dc.contributor.author Muhonen, Leea H
dc.contributor.author Ojanperä, Ilkka A
dc.date.accessioned 2017-07-09T03:18:58Z
dc.date.available 2017-07-09T03:18:58Z
dc.date.issued 2017-07-06
dc.identifier.citation BMC Psychiatry. 2017 Jul 06;17(1):245
dc.identifier.uri http://hdl.handle.net/10138/198580
dc.description.abstract Abstract Background Polydrug abuse is a known problem among opioid-dependent patients receiving opioid maintenance treatment (OMT). However, improved laboratory diagnostics is required to reveal polydrug abuse in its current scope. Furthermore, there are few studies focusing on the relationship between polydrug abuse and adequacy of the dose of OMT medicine. This study aimed to evaluate the polydrug abuse among opioid-dependent patients receiving OMT with inadequate (Group IA) and adequate (Group A) doses of OMT medicine as experienced by the patients. Craving for opioids and withdrawal symptoms were evaluated as indicators of the adequacy rating. Methods This is a retrospective register-based study of 60 OMT patients on either methadone or sublingual buprenorphine/naloxone medication, whose polydrug abuse was studied from urine samples by means of a comprehensive high-resolution mass spectrometry method. Results Inadequate doses of the OMT medicines were associated with higher subjective withdrawal scores and craving for opioids. Six groups of abused substances (benzodiazepines, amphetamines, opioids, cannabis, new psychoactive substances, and non-prescribed psychotropic medicines) were found among OMT patients. Group IA patients showed significantly more abuse of benzodiazepines and amphetamines than the Group A patients. All the new psychoactive substances and most of the non-prescribed psychotropic medicines were detected from the Group IA patients. There was no difference in the doses of the OMT medicine between Groups IA and A patients. Conclusions Polydrug abuse, detected by definitive laboratory methods, was widespread and more common among Group IA than Group A patients, emphasizing the requirement for individual OMT medicine dose adjustment.
dc.publisher BioMed Central
dc.subject Opioid maintenance treatment
dc.subject Polydrug abuse
dc.subject Dose
dc.subject Drug screening
dc.subject Time-of-flight mass spectrometry
dc.title Polydrug abuse among opioid maintenance treatment patients is related to inadequate dose of maintenance treatment medicine
dc.date.updated 2017-07-09T03:18:58Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle

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