Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds : A case study of the Norwegian Lundehund

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dc.contributor University of Helsinki, Biosciences en
dc.contributor University of Helsinki, Research Programs Unit en
dc.contributor University of Helsinki, Research Programs Unit en
dc.contributor.author Stronen, Astrid V.
dc.contributor.author Salmela, Elina
dc.contributor.author Baldursdottir, Birna K.
dc.contributor.author Berg, Peer
dc.contributor.author Espelien, Ingvild S.
dc.contributor.author Järvi, Kirsi
dc.contributor.author Jensen, Henrik
dc.contributor.author Kristensen, Torsten N.
dc.contributor.author Melis, Claudia
dc.contributor.author Manenti, Tommaso
dc.contributor.author Lohi, Hannes
dc.contributor.author Pertoldi, Cino
dc.date.accessioned 2017-07-11T07:04:01Z
dc.date.available 2017-07-11T07:04:01Z
dc.date.issued 2017-06-01
dc.identifier.citation Stronen , A V , Salmela , E , Baldursdottir , B K , Berg , P , Espelien , I S , Järvi , K , Jensen , H , Kristensen , T N , Melis , C , Manenti , T , Lohi , H & Pertoldi , C 2017 , ' Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds : A case study of the Norwegian Lundehund ' , PLoS One , vol. 12 , no. 6 , 0177429 . https://doi.org/10.1371/journal.pone.0177429 en
dc.identifier.issn 1932-6203
dc.identifier.other PURE: 86805643
dc.identifier.other PURE UUID: c895e717-f1ac-4fba-8b5b-ad6850fadcc3
dc.identifier.other WOS: 000402611800009
dc.identifier.other Scopus: 85020047165
dc.identifier.uri http://hdl.handle.net/10138/199198
dc.description.abstract Genetic rescue, outcrossing with individuals from a related population, is used to augment genetic diversity in populations threatened by severe inbreeding and extinction. The endangered Norwegian Lundehund dog underwent at least two severe bottlenecks in the 1940s and 1960s that each left only five inbred dogs, and the approximately 1500 dogs remaining world-wide today appear to descend from only two individuals. The Lundehund has a high prevalence of a gastrointestinal disease, to which all remaining dogs may be predisposed. Outcrossing is currently performed with three Nordic Spitz breeds: Norwegian Buhund, Icelandic Sheepdog, and Norrbottenspets. Examination of single nucleotide polymorphism (SNP) genotypes based on 165K loci in 48 dogs from the four breeds revealed substantially lower genetic diversity for the Lundehund (H-E 0.035) than for other breeds (H-E 0.209-0.284). Analyses of genetic structure with > 15K linkage disequilibrium-pruned SNPs showed four distinct genetic clusters. Pairwise F-ST values between Lundehund and the candidate breeds were highest for Icelandic Sheepdog, followed by Buhund and Norrbottenspets. We assessed the presence of outlier loci among candidate breeds and examined flanking genome regions (1 megabase) for genes under possible selection to identify potential adaptive differences among breeds; outliers were observed in flanking regions of genes associated with key functions including the immune system, metabolism, cognition and physical development. We suggest crossbreeding with multiple breeds as the best strategy to increase genetic diversity for the Lundehund and to reduce the incidence of health problems. For this project, the three candidate breeds were first selected based on phenotypes and then subjected to genetic investigation. Because phenotypes are often paramount for domestic breed owners, such a strategy could provide a helpful approach for genetic rescue and restoration of other domestic populations at risk, by ensuring the involvement of owners, breeders and managers at the start of the project. en
dc.format.extent 18
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights en
dc.subject POPULATION en
dc.subject CONSERVATION en
dc.subject ANCESTRY en
dc.subject MODEL en
dc.subject LOCI en
dc.subject 3111 Biomedicine en
dc.title Genetic rescue of an endangered domestic animal through outcrossing with closely related breeds : A case study of the Norwegian Lundehund en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1371/journal.pone.0177429
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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