Ejection fraction in myocardial perfusion imaging assessed with a dynamic phantom: comparison between IQ-SPECT and LEHR

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dc.contributor.author Hippeläinen, Eero
dc.contributor.author Mäkelä, Teemu
dc.contributor.author Kaasalainen, Touko
dc.contributor.author Kaleva, Erna
dc.date.accessioned 2017-07-23T03:14:43Z
dc.date.available 2017-07-23T03:14:43Z
dc.date.issued 2017-07-19
dc.identifier.citation EJNMMI Physics. 2017 Jul 19;4(1):20
dc.identifier.uri http://hdl.handle.net/10138/203077
dc.description.abstract Abstract Background Developments in single photon emission tomography instrumentation and reconstruction methods present a potential for decreasing acquisition times. One of such recent options for myocardial perfusion imaging (MPI) is IQ-SPECT. This study was motivated by the inconsistency in the reported ejection fraction (EF) and left ventricular (LV) volume results between IQ-SPECT and more conventional low-energy high-resolution (LEHR) collimation protocols. IQ-SPECT and LEHR quantitative results were compared while the equivalent number of iterations (EI) was varied. The end-diastolic (EDV) and end-systolic volumes (ESV) and the derived EF values were investigated. A dynamic heart phantom was used to produce repeatable ESVs, EDVs and EFs. Phantom performance was verified by comparing the set EF values to those measured from a gated multi-slice X-ray computed tomography (CT) scan (EFTrue). The phantom with an EF setting of 45, 55, 65 and 70% was imaged with both IQ-SPECT and LEHR protocols. The data were reconstructed with different EI, and two commonly used clinical myocardium delineation software were used to evaluate the LV volumes. Results The CT verification showed that the phantom EF settings were repeatable and accurate with the EFTrue being within 1% point from the manufacture’s nominal value. Depending on EI both MPI protocols can be made to produce correct EF estimates, but IQ-SPECT protocol produced on average 41 and 42% smaller EDV and ESV when compared to the phantom’s volumes, while LEHR protocol underestimated volumes by 24 and 21%, respectively. The volume results were largely similar between the delineation methods used. Conclusions The reconstruction parameters can greatly affect the volume estimates obtained from perfusion studies. IQ-SPECT produces systematically smaller LV volumes than the conventional LEHR MPI protocol. The volume estimates are also software dependent.
dc.publisher Springer International Publishing
dc.subject Myocardial perfusion imaging
dc.subject SPECT
dc.subject Gated CT
dc.subject IQ-SPECT
dc.subject LEHR
dc.title Ejection fraction in myocardial perfusion imaging assessed with a dynamic phantom: comparison between IQ-SPECT and LEHR
dc.date.updated 2017-07-23T03:14:44Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle

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