Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound

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http://hdl.handle.net/10138/203416

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Nieminen , H J , Ylitalo , T , Suuronen , J-P , Rahunen , K , Salmi , A , Saarakkala , S , Serimaa , R & Haeggstrom , E 2015 , ' Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound ' , Ultrasound in Medicine & Biology , vol. 41 , no. 8 , pp. 2259-2265 . https://doi.org/10.1016/j.ultrasmedbio.2015.03.025

Title: Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound
Author: Nieminen, Heikki J.; Ylitalo, Tuomo; Suuronen, Jussi-Petteri; Rahunen, Krista; Salmi, Ari; Saarakkala, Simo; Serimaa, Ritva; Haeggstrom, Edward
Contributor: University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
Date: 2015-08
Language: eng
Number of pages: 7
Belongs to series: Ultrasound in Medicine & Biology
ISSN: 0301-5629
URI: http://hdl.handle.net/10138/203416
Abstract: There is no cure for osteoarthritis. Current drug delivery relies on systemic delivery or injections into the joint. Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies. We investigated whether intense megahertz ultrasound (frequency: 1.138 MHz, peak positive pressure: 2.7 MPa, I-spta: 5 W/cm(2), beam width: 5.7 mm at -6 dB, duty cycle: 5%, pulse repetition frequency: 285 Hz, mechanical index: 1.1) can deliver agents into AC without damaging it. Using ultrasound, we delivered a drug surrogate down to a depth corresponding to 53% depth of the AC thickness without causing histologically detectable damage to the AC. This may be important because early osteoarthritis typically exhibits histopathologic changes in the superficial AC. In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage. (E-mail: heikki.nieminen@helsinki.fi) (C) 2015 World Federation for Ultrasound in Medicine & Biology.
Subject: Ultrasound
Drug delivery
Osteoarthritis
Cartilage repair
DRUG-DELIVERY
OSTEOARTHRITIS
TRANSPORT
114 Physical sciences
318 Medical biotechnology
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