An interaction between NDE1 and high birth weight increases schizophrenia susceptibility

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Wegelius , A , Pankakoski , M , Tomppo , L , Lehto , U , Lonnqvist , J , Suvisaari , J , Paunio , T & Hennah , W 2015 , ' An interaction between NDE1 and high birth weight increases schizophrenia susceptibility ' , Psychiatry Research , vol. 230 , no. 2 , pp. 194-199 . https://doi.org/10.1016/j.psychres.2015.08.038

Title: An interaction between NDE1 and high birth weight increases schizophrenia susceptibility
Author: Wegelius, Asko; Pankakoski, Maiju; Tomppo, Liisa; Lehto, Ulriika; Lonnqvist, Jouko; Suvisaari, Jaana; Paunio, Tiina; Hennah, William
Other contributor: University of Helsinki, Department of Psychiatry
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Department of Psychiatry
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland




Date: 2015-12-15
Language: eng
Number of pages: 6
Belongs to series: Psychiatry Research
ISSN: 0165-1781
DOI: https://doi.org/10.1016/j.psychres.2015.08.038
URI: http://hdl.handle.net/10138/203727
Abstract: Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders has gained momentum. We used multivariate GEE regression modeling to investigate the interaction between genes of the DISCI pathway and birth weight, in relation to schizophrenia susceptibility in a Finnish schizophrenia family cohort. The study sample consisted of 457 subjects with both genotype and birth weight information. Gender and place of birth were adjusted for in the models. We found a significant interaction between birth weight and two NDE1 markers in relation to increased schizophrenia risk: a four SNP haplotype spanning NDE1 (b = 1.26, SE= 0.5, p = 0.012) and one of its constituent SNPs rs4781678 (b = 1.33, SE = 0.51, p = 0.010). Specifically, high birth weight (> 4000 g) was associated with increased schizophrenia risk among subjects homozygous for the previously identified risk alleles. The study was based on a family study sample with high genetic loading for schizophrenia and thus our findings cannot directly be generalized as representing the general population. Our results suggest that the functions mediated by NDE1 during the early stages of neurodevelopment are susceptible to the additional disruptive effects of pre- and perinatal environmental factors associated with high birth weight, augmenting schizophrenia susceptibility. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
Subject: Birth weight
Neurodevelopment
Schizophrenia
Gene
Environment
DISC1
NDE1
FETAL-GROWTH
OBSTETRIC COMPLICATIONS
ENVIRONMENT INTERACTION
GENE-ENVIRONMENT
RISK-FACTORS
FAMILIES
HYPOXIA
FINLAND
COHORT
3124 Neurology and psychiatry
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