An interaction between NDE1 and high birth weight increases schizophrenia susceptibility

Show simple item record Wegelius, Asko Pankakoski, Maiju Tomppo, Liisa Lehto, Ulriika Lonnqvist, Jouko Suvisaari, Jaana Paunio, Tiina Hennah, William 2017-07-25T06:09:00Z 2017-07-25T06:09:00Z 2015-12-15
dc.identifier.citation Wegelius , A , Pankakoski , M , Tomppo , L , Lehto , U , Lonnqvist , J , Suvisaari , J , Paunio , T & Hennah , W 2015 , ' An interaction between NDE1 and high birth weight increases schizophrenia susceptibility ' , Psychiatry Research , vol. 230 , no. 2 , pp. 194-199 .
dc.identifier.other PURE: 58297490
dc.identifier.other PURE UUID: 11ed9d19-d9ad-4ad9-84fd-44787080f0ca
dc.identifier.other WOS: 000366077400011
dc.identifier.other Scopus: 84940851172
dc.description.abstract Pre- and perinatal environmental factors have been shown to increase schizophrenia risk particularly when combined with genetic liability. The investigation of specific gene environment interactions in the etiology of psychiatric disorders has gained momentum. We used multivariate GEE regression modeling to investigate the interaction between genes of the DISCI pathway and birth weight, in relation to schizophrenia susceptibility in a Finnish schizophrenia family cohort. The study sample consisted of 457 subjects with both genotype and birth weight information. Gender and place of birth were adjusted for in the models. We found a significant interaction between birth weight and two NDE1 markers in relation to increased schizophrenia risk: a four SNP haplotype spanning NDE1 (b = 1.26, SE= 0.5, p = 0.012) and one of its constituent SNPs rs4781678 (b = 1.33, SE = 0.51, p = 0.010). Specifically, high birth weight (> 4000 g) was associated with increased schizophrenia risk among subjects homozygous for the previously identified risk alleles. The study was based on a family study sample with high genetic loading for schizophrenia and thus our findings cannot directly be generalized as representing the general population. Our results suggest that the functions mediated by NDE1 during the early stages of neurodevelopment are susceptible to the additional disruptive effects of pre- and perinatal environmental factors associated with high birth weight, augmenting schizophrenia susceptibility. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Psychiatry Research
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Birth weight
dc.subject Neurodevelopment
dc.subject Schizophrenia
dc.subject Gene
dc.subject Environment
dc.subject DISC1
dc.subject NDE1
dc.subject FETAL-GROWTH
dc.subject RISK-FACTORS
dc.subject FAMILIES
dc.subject HYPOXIA
dc.subject FINLAND
dc.subject COHORT
dc.subject 3124 Neurology and psychiatry
dc.title An interaction between NDE1 and high birth weight increases schizophrenia susceptibility en
dc.type Article
dc.contributor.organization Department of Psychiatry
dc.contributor.organization Clinicum
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization William Hennah / Principal Investigator
dc.contributor.organization HUS Psychiatry
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0165-1781
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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