Metabolic milieu associates with impaired skeletal characteristics in obesity

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http://hdl.handle.net/10138/203754

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Viljakainen , H T , Koistinen , H A , Tervahartiala , T , Sorsa , T , Andersson , S & Mäkitie , O 2017 , ' Metabolic milieu associates with impaired skeletal characteristics in obesity ' , PLoS One , vol. 12 , no. 6 , 0179660 . https://doi.org/10.1371/journal.pone.0179660

Title: Metabolic milieu associates with impaired skeletal characteristics in obesity
Author: Viljakainen, Heli T.; Koistinen, Heikki A.; Tervahartiala, Taina; Sorsa, Timo; Andersson, Sture; Mäkitie, Outi
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Children and Adolescents
Date: 2017-06-22
Language: eng
Number of pages: 13
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/203754
Abstract: High leptin concentration, low-grade inflammation, and insulin resistance often coexist in obese subjects; this adverse metabolic milieu may be the main culprit for increased fracture risk and impaired bone quality seen in patients with type 2 diabetes. We examined the associations of leptin, hs (high sensitivity)-CRP and insulin resistance with bone turnover markers (BTMs) and bone characteristics in 55 young obese adults (median BMI 40 kg/m(2)) and 65 non-obese controls. Mean age of the subjects was 19.5 +/- 2.5 years (mean +/- SD). Concentrations of leptin, adiponectin, hs-CRP, MMP-8 and TIMP-1, fasting plasma glucose and insulin (to calculate HOMA), BTMs (BAP, P1NP, CTX-1, and TRAC5b) were measured. Bone characteristics were determined with pQCT at radius and tibia, and with DXA for central sites. Leptin, hs-CRP and HOMA correlated inversely with BTMs: the partial coefficients were 1.5-1.9 fold higher in males than in females. After adjusting for age, BMI, and other endocrine factors, leptin displayed an independent effect in males on radial bone mass (p = 0.019), tibial trabecular density (p = 0.025) and total hip BMD (p = 0.043), with lower densities in males with high leptin. In females, the model adjusting for age, BMI, and other endocrine factors, revealed that hs-CRP had independent effects on radial bone mass (p = 0.034) and lumbar spine BMD (p = 0.016), women with high hs-CRP having lower values. Partial correlations of adiponectin and TIMP-1 with bone characteristics were discrepant; MMP-8 showed no associations. In conclusion, in young obese adults and their controls, leptin, hs-CRP and HOMA associate inversely with BTMs and bone characteristics. Leptin appears to be the key independent effector in males, whereas hs-CRP displayed a predominant role in females.
Subject: C-REACTIVE PROTEIN
BONE-MINERAL DENSITY
TYPE-2 DIABETES-MELLITUS
INSULIN-RESISTANCE
ADIPOSE-TISSUE
POSTMENOPAUSAL WOMEN
FRACTURE RISK
INFLAMMATION
TURNOVER
LEPTIN
3121 Internal medicine
3123 Gynaecology and paediatrics
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