Metabolic milieu associates with impaired skeletal characteristics in obesity

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Viljakainen , H T , Koistinen , H A , Tervahartiala , T , Sorsa , T , Andersson , S & Mäkitie , O 2017 , ' Metabolic milieu associates with impaired skeletal characteristics in obesity ' , PLoS One , vol. 12 , no. 6 , 0179660 .

Title: Metabolic milieu associates with impaired skeletal characteristics in obesity
Author: Viljakainen, Heli T.; Koistinen, Heikki A.; Tervahartiala, Taina; Sorsa, Timo; Andersson, Sture; Mäkitie, Outi
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Department of Medicine
Endokrinologian yksikkö
HUS Abdominal Center
Department of Oral and Maxillofacial Diseases
HUS Head and Neck Center
Timo Sorsa / Principal Investigator
Suu- ja leukakirurgian yksikkö
Lastentautien yksikkö
Date: 2017-06-22
Language: eng
Number of pages: 13
Belongs to series: PLoS One
ISSN: 1932-6203
Abstract: High leptin concentration, low-grade inflammation, and insulin resistance often coexist in obese subjects; this adverse metabolic milieu may be the main culprit for increased fracture risk and impaired bone quality seen in patients with type 2 diabetes. We examined the associations of leptin, hs (high sensitivity)-CRP and insulin resistance with bone turnover markers (BTMs) and bone characteristics in 55 young obese adults (median BMI 40 kg/m(2)) and 65 non-obese controls. Mean age of the subjects was 19.5 +/- 2.5 years (mean +/- SD). Concentrations of leptin, adiponectin, hs-CRP, MMP-8 and TIMP-1, fasting plasma glucose and insulin (to calculate HOMA), BTMs (BAP, P1NP, CTX-1, and TRAC5b) were measured. Bone characteristics were determined with pQCT at radius and tibia, and with DXA for central sites. Leptin, hs-CRP and HOMA correlated inversely with BTMs: the partial coefficients were 1.5-1.9 fold higher in males than in females. After adjusting for age, BMI, and other endocrine factors, leptin displayed an independent effect in males on radial bone mass (p = 0.019), tibial trabecular density (p = 0.025) and total hip BMD (p = 0.043), with lower densities in males with high leptin. In females, the model adjusting for age, BMI, and other endocrine factors, revealed that hs-CRP had independent effects on radial bone mass (p = 0.034) and lumbar spine BMD (p = 0.016), women with high hs-CRP having lower values. Partial correlations of adiponectin and TIMP-1 with bone characteristics were discrepant; MMP-8 showed no associations. In conclusion, in young obese adults and their controls, leptin, hs-CRP and HOMA associate inversely with BTMs and bone characteristics. Leptin appears to be the key independent effector in males, whereas hs-CRP displayed a predominant role in females.
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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