Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study

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http://hdl.handle.net/10138/203756

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Johnson , L S B , Salonen , M , Kajantie , E , Conen , D , Healey , J S , Osmond , C & Eriksson , J G 2017 , ' Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study ' , Journal of the American Heart Association , vol. 6 , no. 6 , 006036 . https://doi.org/10.1161/JAHA.117.006036

Title: Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study
Author: Johnson, Linda S. B.; Salonen, Minna; Kajantie, Eero; Conen, David; Healey, Jeff S.; Osmond, Clive; Eriksson, Johan G.
Contributor: University of Helsinki, Department of Public Health
University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
Date: 2017-06
Language: eng
Number of pages: 8
Belongs to series: Journal of the American Heart Association
ISSN: 2047-9980
URI: http://hdl.handle.net/10138/203756
Abstract: Background-Early life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown. Methods and Results-The Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934-1944. Follow-up was through national registries, and ended on December 31, 2013, with 907 incident cases. Cox regression analyses stratified on year of birth were constructed for perinatal variables and incident AF, adjusting for offspring sex, gestational age, and socioeconomic status at birth. There was a significant U-shaped association between birth weight and AF (P for quadratic term = 0.01). The lowest risk of AF was found among those with a birth weight of 3.4 kg (3.8 kg for women [85th percentile] and 3.0 kg for men [17th percentile]). High maternal body mass index (>= 30 kg/m(2)) predicted offspring AF; hazard ratio 1.36 (95% CI 1.07-1.74, P = 0.01) compared with normal body mass index ( Conclusions-High maternal body mass index during pregnancy and maternal height are previously undescribed predictors of offspring AF. Efforts to prevent maternal obesity might reduce later AF in offspring. Birth weight has a U-shaped relation to incident AF independent of other perinatal variables.
Subject: atrial fibrillation
hypertension
population science
population studies
risk prediction
MIDDLE-AGED MEN
PREVENTIVE PROJECT
MATERNAL OBESITY
WEIGHT
HEALTH
PREGNANCY
HEIGHT
IMPACT
CHILDREN
GROWTH
3121 General medicine, internal medicine and other clinical medicine
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