Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort

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Husa , A P , Moilanen , J , Murray , G K , Marttila , R , Haapea , M , Rannikko , I , Barnett , J H , Jones , P B , Isohanni , M , Remes , A M , Koponen , H , Miettunen , J & Jaaskelainen , E 2017 , ' Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort ' Psychiatry Research , vol. 247 , pp. 130-138 . DOI: 10.1016/j.psychres.2016.10.085

Title: Lifetime antipsychotic medication and cognitive performance in schizophrenia at age 43 years in a general population birth cohort
Author: Husa, Anja P.; Moilanen, Jani; Murray, Graham K.; Marttila, Riikka; Haapea, Marianne; Rannikko, Irina; Barnett, Jennifer H.; Jones, Peter B.; Isohanni, Matti; Remes, Anne M.; Koponen, Hannu; Miettunen, Jouko; Jaaskelainen, Erika
Contributor: University of Helsinki, Department of Psychiatry
Date: 2017-01
Language: eng
Number of pages: 9
Belongs to series: Psychiatry Research
ISSN: 0165-1781
URI: http://hdl.handle.net/10138/205956
Abstract: This naturalistic study analysed the association between cumulative lifetime antipsychotic dose and cognition in schizophrenia after an average of 16.5 years of illness. Sixty participants with schizophrenia and 191 controls from the Northern Finland Birth Cohort 1966 were assessed at age 43 years with a neurocognitive test battery. Cumulative lifetime antipsychotic dose-years were collected from medical records and interviews. The association between antipsychotic dose-years and a cognitive composite score based on principal component analysis was analysed using linear regression. Higher lifetime antipsychotic dose-years were significantly associated with poorer cognitive composite score, when adjusted for gender, onset age and lifetime hospital treatment days. The effects of typical and atypical antipsychotics did not differ. This is the first report of an association between cumulative lifetime antipsychotic dose and global cognition in midlife schizophrenia. Based on these data, higher lifetime antipsychotic dose-years may be associated with poorer cognitive performance at age 43 years. Potential biases related to the naturalistic design may partly explain the results; nonetheless, it is possible that large antipsychotic doses harm cognition in schizophrenia in the long-term.
Subject: Psychosis
Cognition
Treatment
Cross-sectional
Adverse effect
FOLLOW-UP
1ST-EPISODE PSYCHOSIS
LONGITUDINAL MRI
DOSE-REDUCTION
METAANALYSIS
DEFICITS
NEUROCOGNITION
RELIABILITY
RISPERIDONE
OLANZAPINE
3124 Neurology and psychiatry
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