Paju , S , Oittinen , J , Haapala , H , Asikainen , S , Paavonen , J & Pussinen , P J 2017 , ' Porphyromonas gingivalis may interfere with conception in women ' , Journal of Oral Microbiology , vol. 9 , 1330644 . https://doi.org/10.1080/20002297.2017.1330644
Title: | Porphyromonas gingivalis may interfere with conception in women |
Author: | Paju, Susanna; Oittinen, Juha; Haapala, Henna; Asikainen, Sirkka; Paavonen, Jorma; Pussinen, Pirkko J. |
Contributor organization: | University of Helsinki Clinicum Oral and Maxillofacial Surgery Department of Obstetrics and Gynecology Department of Oral and Maxillofacial Diseases HUS Gynecology and Obstetrics HUS Head and Neck Center |
Date: | 2017 |
Language: | eng |
Number of pages: | 6 |
Belongs to series: | Journal of Oral Microbiology |
ISSN: | 2000-2297 |
DOI: | https://doi.org/10.1080/20002297.2017.1330644 |
URI: | http://hdl.handle.net/10138/205957 |
Abstract: | In this observational and prospective study, we investigated if microbiological and serological markers of periodontitis associated with conception in 256 non-pregnant women (Mage = 29.2 years; range 19-42 years). Clinical oral and gynecological examinations were performed, major periodontal pathogens in the saliva were detected, and serum and saliva antibodies against major periodontal pathogens were analyzed. The follow-up period for becoming pregnant was 12 months. Porphyromonas gingivalis was significantly (p = 0.032) more frequently detected in the saliva among those who did not become pregnant (8.3%) than among those who became pregnant (2.1%). The median levels of salivary P. gingivalis immunoglobulin A (IgA; p = 0.006) and IgG (p = 0.007) antibodies were higher among those who did not become pregnant compared to those who became pregnant. Hazard ratios (HR) for not becoming pregnant were HR = 3.75 (95% confidence interval [CI] 1.01-13.9; p = 0.048) if the subject was polymerase chain reaction-positive for P. gingivalis with high salivary antibodies against it, and HR = 1.62 (95% CI 1.03-2.54; p = 0.035) if she had high levels of serum P. gingivalis IgA and signs of periodontal infection. P. gingivalis associated with no success in getting pregnant. |
Subject: |
Periodontal-systemic disease
interactions microbiology oral hygiene periodontal diseases periodontitis women's health PERIODONTAL PATHOGENS INFLAMMATION DISEASE CARRIAGE 1183 Plant biology, microbiology, virology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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