Porphyromonas gingivalis may interfere with conception in women

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Paju , S , Oittinen , J , Haapala , H , Asikainen , S , Paavonen , J & Pussinen , P J 2017 , ' Porphyromonas gingivalis may interfere with conception in women ' , Journal of Oral Microbiology , vol. 9 , 1330644 . https://doi.org/10.1080/20002297.2017.1330644

Title: Porphyromonas gingivalis may interfere with conception in women
Author: Paju, Susanna; Oittinen, Juha; Haapala, Henna; Asikainen, Sirkka; Paavonen, Jorma; Pussinen, Pirkko J.
Contributor organization: University of Helsinki
Oral and Maxillofacial Surgery
Department of Obstetrics and Gynecology
Department of Oral and Maxillofacial Diseases
HUS Gynecology and Obstetrics
HUS Head and Neck Center
Date: 2017
Language: eng
Number of pages: 6
Belongs to series: Journal of Oral Microbiology
ISSN: 2000-2297
DOI: https://doi.org/10.1080/20002297.2017.1330644
URI: http://hdl.handle.net/10138/205957
Abstract: In this observational and prospective study, we investigated if microbiological and serological markers of periodontitis associated with conception in 256 non-pregnant women (Mage = 29.2 years; range 19-42 years). Clinical oral and gynecological examinations were performed, major periodontal pathogens in the saliva were detected, and serum and saliva antibodies against major periodontal pathogens were analyzed. The follow-up period for becoming pregnant was 12 months. Porphyromonas gingivalis was significantly (p = 0.032) more frequently detected in the saliva among those who did not become pregnant (8.3%) than among those who became pregnant (2.1%). The median levels of salivary P. gingivalis immunoglobulin A (IgA; p = 0.006) and IgG (p = 0.007) antibodies were higher among those who did not become pregnant compared to those who became pregnant. Hazard ratios (HR) for not becoming pregnant were HR = 3.75 (95% confidence interval [CI] 1.01-13.9; p = 0.048) if the subject was polymerase chain reaction-positive for P. gingivalis with high salivary antibodies against it, and HR = 1.62 (95% CI 1.03-2.54; p = 0.035) if she had high levels of serum P. gingivalis IgA and signs of periodontal infection. P. gingivalis associated with no success in getting pregnant.
Subject: Periodontal-systemic disease
oral hygiene
periodontal diseases
women's health
1183 Plant biology, microbiology, virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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