Human ROBO1 regulates white matter structure in corpus callosum

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http://hdl.handle.net/10138/205960

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Darki , F , Massinen , S , Salmela , E , Matsson , H , Peyrard-Janvid , M , Klingberg , T & Kere , J 2017 , ' Human ROBO1 regulates white matter structure in corpus callosum ' , Brain structure & function , vol. 222 , no. 2 , pp. 707-716 . https://doi.org/10.1007/s00429-016-1240-y

Title: Human ROBO1 regulates white matter structure in corpus callosum
Author: Darki, Fahimeh; Massinen, Satu; Salmela, Elina; Matsson, Hans; Peyrard-Janvid, Myriam; Klingberg, Torkel; Kere, Juha
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Hannes Tapani Lohi / Principal Investigator
University of Helsinki, University of Helsinki
Date: 2017-03
Language: eng
Number of pages: 10
Belongs to series: Brain structure & function
ISSN: 1863-2653
URI: http://hdl.handle.net/10138/205960
Abstract: The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.
Subject: Structural MRI
DTI
Single nucleotide polymorphism
Roundabout
Axon guidance receptor homolog 1
Axonal pathfinding
CORTICAL INTERNEURONS
CEREBRAL-CORTEX
MIGRATION
FOREBRAIN
GENE
MICROSTRUCTURE
ASSOCIATION
GUIDANCE
TRACTS
SLIT
3111 Biomedicine
3112 Neurosciences
3124 Neurology and psychiatry
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