Human ROBO1 regulates white matter structure in corpus callosum

Show simple item record Darki, Fahimeh Massinen, Satu Salmela, Elina Matsson, Hans Peyrard-Janvid, Myriam Klingberg, Torkel Kere, Juha 2017-08-01T09:10:01Z 2017-08-01T09:10:01Z 2017-03
dc.identifier.citation Darki , F , Massinen , S , Salmela , E , Matsson , H , Peyrard-Janvid , M , Klingberg , T & Kere , J 2017 , ' Human ROBO1 regulates white matter structure in corpus callosum ' , Brain structure & function , vol. 222 , no. 2 , pp. 707-716 .
dc.identifier.other PURE: 87673400
dc.identifier.other PURE UUID: d92b28f0-df51-44b7-b7d2-e0a5c4946e85
dc.identifier.other WOS: 000396034300002
dc.identifier.other Scopus: 84973163936
dc.description.abstract The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Brain structure & function
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Structural MRI
dc.subject DTI
dc.subject Single nucleotide polymorphism
dc.subject Roundabout
dc.subject Axon guidance receptor homolog 1
dc.subject Axonal pathfinding
dc.subject MIGRATION
dc.subject FOREBRAIN
dc.subject GENE
dc.subject ASSOCIATION
dc.subject GUIDANCE
dc.subject TRACTS
dc.subject SLIT
dc.subject 3111 Biomedicine
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Human ROBO1 regulates white matter structure in corpus callosum en
dc.type Article
dc.contributor.organization Research Programs Unit
dc.contributor.organization Juha Kere / Principal Investigator
dc.contributor.organization Research Programme of Molecular Medicine
dc.contributor.organization Hannes Tapani Lohi / Principal Investigator
dc.contributor.organization Onkamo Research Group
dc.contributor.organization Research Programme for Molecular Neurology
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1863-2653
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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