Intrinsic incompatibilities evolving as a by-product of divergent ecological selection : Considering them in empirical studies on divergence with gene flow

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Kulmuni , J & Westram , A M 2017 , ' Intrinsic incompatibilities evolving as a by-product of divergent ecological selection : Considering them in empirical studies on divergence with gene flow ' , Molecular Ecology , vol. 26 , no. 12 , pp. 3093-3103 . https://doi.org/10.1111/mec.14147

Title: Intrinsic incompatibilities evolving as a by-product of divergent ecological selection : Considering them in empirical studies on divergence with gene flow
Author: Kulmuni, J.; Westram, A. M.
Contributor: University of Helsinki, Biosciences
Date: 2017-06
Language: eng
Number of pages: 11
Belongs to series: Molecular Ecology
ISSN: 0962-1083
URI: http://hdl.handle.net/10138/205966
Abstract: The possibility of intrinsic barriers to gene flow is often neglected in empirical research on local adaptation and speciation with gene flow, for example when interpreting patterns observed in genome scans. However, we draw attention to the fact that, even with gene flow, divergent ecological selection may generate intrinsic barriers involving both ecologically selected and other interacting loci. Mechanistically, the link between the two types of barriers may be generated by genes that have multiple functions (i.e., pleiotropy), and/or by gene interaction networks. Because most genes function in complex networks, and their evolution is not independent of other genes, changes evolving in response to ecological selection can generate intrinsic barriers as a by-product. A crucial question is to what extent such by-product barriers contribute to divergence and speciation-that is whether they stably reduce gene flow. We discuss under which conditions by-product barriers may increase isolation. However, we also highlight that, depending on the conditions (e.g., the amount of gene flow and the strength of selection acting on the intrinsic vs. the ecological barrier component), the intrinsic incompatibility may actually destabilize barriers to gene flow. In practice, intrinsic barriers generated as a by-product of divergent ecological selection may generate peaks in genome scans that cannot easily be interpreted. We argue that empirical studies on divergence with gene flow should consider the possibility of both ecological and intrinsic barriers. Future progress will likely come from work combining population genomic studies, experiments quantifying fitness and molecular studies on protein function and interactions.
Subject: divergent ecological selection
gene interaction
intrinsic incompatibility
outlier scan
pleiotropy
speciation
PARAPATRIC SPECIATION
HYBRID INCOMPATIBILITIES
LOCAL ADAPTATION
GENOMIC ISLANDS
EVOLUTION
PLEIOTROPY
EPISTASIS
COMPLEXITY
PARALLEL
YEAST
1181 Ecology, evolutionary biology
1182 Biochemistry, cell and molecular biology
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