Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

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Comandolli-Wyrepkowski , C D , Grafova , I , Naiff , M D F , Avella , M , Gentile , G , Grafov , A & Ramos Franco , A M 2017 , ' Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine ' , Acta Amazonica , vol. 47 , no. 1 , pp. 39-45 . https://doi.org/10.1590/1809-4392201601333

Title: Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine
Author: Comandolli-Wyrepkowski, Claudia Dantas; Grafova, Iryna; Naiff, Maricleide de Farias; Avella, Maurizio; Gentile, Gennaro; Grafov, Andriy; Ramos Franco, Antonia Maria
Contributor: University of Helsinki, Department of Chemistry
University of Helsinki, Department of Chemistry
Date: 2017
Language: eng
Number of pages: 7
Belongs to series: Acta Amazonica
ISSN: 0044-5967
URI: http://hdl.handle.net/10138/208069
Abstract: Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day(-1). After treatment tissue samples of lesions were evaluated by histology, transmission electron microscopy and biopsy cultivation. Compared with untreated group, topical treatment with hydrating emulsion with 10% PI and usnic acid (ACE5AU) showed significantly decrease in volume lesion (P= 0.028) on 20th day after the end of the treatment with reduction of 27.37%. Topical treatment with anhydrous emulsion with 10% PI and usnic acid (ACPU) reduces parasite burden in Golden hamsters. This study demonstrated the potential of topical treatment to reduce the number of parasites that could be combined with others drugs and to have a faster and more effective treatment of cutaneous leishmaniasis.
Subject: topical formulations
experimental treatment
pentamidine isethionate
animal model
Leishmania
CLINICAL-TRIAL
DOUBLE-BLIND
NEW-WORLD
STATE
DRUG
116 Chemical sciences
317 Pharmacy
1172 Environmental sciences
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