SynergyFinder : a web application for analyzing drug combination dose-response matrix data

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http://hdl.handle.net/10138/209966

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Ianevski , A , He , L , Aittokallio , T & Tang , J 2017 , ' SynergyFinder : a web application for analyzing drug combination dose-response matrix data ' , Bioinformatics , vol. 33 , no. 15 , pp. 2413-2415 . https://doi.org/10.1093/bioinformatics/btx162

Title: SynergyFinder : a web application for analyzing drug combination dose-response matrix data
Author: Ianevski, Aleksandr; He, Liye; Aittokallio, Tero; Tang, Jing
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, University of Helsinki
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-08-01
Language: eng
Number of pages: 3
Belongs to series: Bioinformatics
ISSN: 1367-4803
URI: http://hdl.handle.net/10138/209966
Abstract: Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the preclinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner.
Subject: CANCER
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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